Abstract：
:Quantitative analysis of the orientational distribution of biological apatite (BAp) crystals is proposed as a new index of bone quality. This study aimed to analyze BAp c-axis orientation in ovariectomized (OVX) monkeys treated with amino-bisphosphonates minodronic acid and alendronate as reference. Sixty female monkeys aged 9-17 years were divided into five groups: one sham group and four OVX groups. The sham group and one OVX group were treated daily with vehicle for 17 months. The other three groups were treated daily with minodronic acid at doses of 0.015 and 0.15 mg/kg, and alendronate at 0.5 mg/kg orally, respectively. The seventh lumbar vertebrae were subjected to analysis of the preferential BAp c-axis orientation in the ventral cortical bone. The BAp c-axis orientation along the craniocaudal axis was significantly increased in the OVX monkeys. The high dose of minodronic acid suppressed the OVX-induced increase in the BAp c-axis orientation, whereas alendronate showed a non-significant tendency to suppress the increase in the orientation. In analysis with other parameters, the BAp c-axis orientation was positively correlated with bone formation indices in biochemical markers and bone histomorphometry and negatively correlated with the increase in lumbar bone mineral density. On the other hand, the BAp c-axis orientation was not correlated with bone resorption indices, except for the eroded surface. These results indicate that the increase in BAp c-axis orientation was ameliorated by minodronic acid treatment in OVX monkeys, mainly by suppression of bone formation increase.
journal_name
J Bone Miner Metabjournal_title
Journal of bone and mineral metabolismauthors
Tanaka M,Matsugaki A,Ishimoto T,Nakano Tdoi
10.1007/s00774-015-0658-2subject
Has Abstractpub_date
2016-03-01 00:00:00pages
234-41issue
2eissn
0914-8779issn
1435-5604pii
10.1007/s00774-015-0658-2journal_volume
34pub_type
杂志文章abstract：:Leptin has been proposed to be a key molecule involved in energy regulation. Based on the generally acknowledged concept that a heavier person has a higher bone density, leptin is thought to be potentially involved in bone metabolism. Serum leptin, various bone markers, and bone mineral density (BMD) were studied in 5...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s007740170050
更新日期：2001-01-01 00:00:00
abstract：:Disturbed zinc (Zn) homeostasis in mammals is mainly characterized by impaired bone generation accompanied with growth retardation. However, the underlying mechanisms that determine how Zn controls bone homeostasis remain to be defined. Zn homeostasis is tightly controlled by Zn transporter families. Recent studies ha...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,评审
doi：10.1007/s00774-012-0409-6
更新日期：2013-03-01 00:00:00
abstract：:Bone is a specialized connective tissue that functions as the load-bearing structure of the body. Free radicals may affect bone remodeling by regulating osteoclast activity in either the physiological or pathological condition. Vitamin E, a lipid-soluble antioxidant, has been demonstrated to offer protection against o...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-010-0159-2
更新日期：2010-09-01 00:00:00
abstract：:We investigated the enhancement of new bone |formation elicited ectopically by recombinant human bone morphogenetic protein-2 (rhBMP-2), using parathyroid hormone (PTH) and a phosphodiesterase inhibitor (PDEi), pentoxifylline (PTX), in an animal model. Collagen sponge sheet discs containing rhBMP were implanted onto t...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-003-0490-y
更新日期：2004-01-01 00:00:00
abstract：:Accumulating evidence has shown that patients with lifestyle diseases such as type 2 diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease are at increased risk of osteoporotic fracture. Fractures deteriorate quality of life, activities of daily living, and mortality as well as a lifesty...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-020-01149-3
更新日期：2020-11-01 00:00:00
abstract：INTRODUCTION:Data is currently lacking regarding association between the cholecystectomy/hepatectomy/pancreatectomy and the development of osteoporotic fracture. A retrospective cohort study was conducted to investigate the relationship between cholecystectomy/hepatectomy/pancreatectomy and the subsequent risk of devel...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-020-01129-7
更新日期：2020-08-05 00:00:00
abstract：:We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-016-0736-0
更新日期：2017-01-01 00:00:00
abstract：:Bone mass differs according to ethnic classification, with individuals of African ancestry attaining the highest measurements across numerous skeletal sites. Elevated bone mass is even maintained in those individuals exposed to adverse environmental factors, suggesting a prominent genetic effect that may have clinical...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-013-0431-3
更新日期：2013-11-01 00:00:00
abstract：:Metabolic bone disease may appear as a complication of obesity surgery. Because an imbalance in the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system may underlie osteoporosis, we aimed to study this system in humans in the metabolic bone disease occurring after obesity surgery. In this study w...
journal_title：Journal of bone and mineral metabolism
pub_type： 临床试验,杂志文章
doi：10.1007/s00774-015-0712-0
更新日期：2016-11-01 00:00:00
abstract：:Concurrent use of bisphosphonate therapy reduces the anabolic effect of teriparatide. Consequently, in clinical practice bisphosphonates are discontinued and teriparatide therapy held for a few months to allow bone turnover to increase. We aimed to evaluate the effect of prior bisphosphonate exposure and the effect of...
journal_title：Journal of bone and mineral metabolism
pub_type： 临床试验,杂志文章
doi：10.1007/s00774-009-0101-7
更新日期：2010-01-01 00:00:00
abstract：:Stimulation of osteoblast proliferation and differentiation is important for the in vivo bone-bonding ability of biomaterials. Previous in vitro studies have used biochemical assays to analyze osteoblast-specific gene expression in cultured osteoblasts. In this study, we generated transgenic mice harboring a monomeric...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-013-0544-8
更新日期：2014-11-01 00:00:00
abstract：:Patients who are diagnosed with osteoporosis and beginning treatment often discontinue their osteoporosis medication relatively early after the start of treatment because of their poor recognition of fracture risk and the asymptomatic nature of osteoporosis. In this study we aimed to assess adherence to treatment with...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00774-009-0112-4
更新日期：2010-03-01 00:00:00
abstract：:Nitrogen-containing bisphosphonates such as zoledronic acid (ZOL) and pamidronate have been widely and successfully used for the treatment of cancer patients with bone metastases and/or hypercalcemia. Accumulating recent reports have shown that cancer patients who have received these bisphosphonates occasionally manif...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-009-0128-9
更新日期：2010-03-01 00:00:00
abstract：:Inactivating mutations and/or deletions of PHEX ( Phosphate-regulating gene with Homologies to Endopeptidase on the X chromosome) are responsible for X-linked hypophosphatemic rickets in humans. In the present study, three Drosophila PHEX homologues (dPHEX-1, -2, -3) were isolated by the screening of a Drosophila cDNA...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-003-0440-8
更新日期：2004-01-01 00:00:00
abstract：:Alendronate has recently been approved for the prevention and treatment of postmenopausal osteoporosis, and its efficacy has been demonstrated in many Western countries. Our present study was performed to evaluate the effect of alendronate on bone mineral density (BMD) and its tolerability in Thais. Eighty postmenopau...
journal_title：Journal of bone and mineral metabolism
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00774-003-0438-2
更新日期：2003-01-01 00:00:00
abstract：:The aim of the study was to assess body composition in subjects with phenylketonuria (PKU). Forty-five patients aged 13.8 ± 5.2 years were evaluated. Among them, 15 patients had not reached sexual maturity, showing normal serum values of phenylalanine (Phe) (subgroup 1), and 30 subjects were sexually mature (Tanner 5 ...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-010-0216-x
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:Physical activity (PA) is a key factor of bone mass acquisition in peripubertal children. Sedentary behavior (SB) has been shown to influence bone outcomes. This study aimed to examine the association between objectively measured PA and SB and bone stiffness in Japanese children. MATERIALS AND METHODS:Par...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-019-01021-z
更新日期：2019-11-01 00:00:00
abstract：:Until now, the effects of phytoestrogen on bone in both women and ovarian hormone-deficient animal models of osteoporosis have remained uncertain. We have aimed here to investigate the effect of genistein (GEN) on trabecular bone quality in ovariectomized (OVX) rats. Forty 7-month-old female Sprague-Dawley rats were r...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-007-0830-4
更新日期：2008-01-01 00:00:00
abstract：:The purpose of this study was to investigate the association of the Singh index, cortical thickness index (CTI) and calcar-to-canal (CC) ratio with bone mineral density (BMD) as well as their relationship with physical parameters [age, gender, height, and body mass index (BMI)] in order to assess their potential as an...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-012-0348-2
更新日期：2012-09-01 00:00:00
abstract：:The aim of this study was to survey the incidence of osteoporotic fragility fractures, which include vertebral, hip, distal radius, and proximal humerus fractures, in patients ≥ 50 years of age, from 2004 to 2015, in Sado City, Japan. We examined temporal changes in the incidence of these fractures from 2010 through 2...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-018-0937-9
更新日期：2019-05-01 00:00:00
abstract：:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-010-0202-3
更新日期：2011-03-01 00:00:00
abstract：:This study aimed to estimate the prevalence of locomotive syndrome, sarcopenia, and frailty and clarify their co-existence in a population-based cohort. The third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted between 2012 and 2013, examining 963 subjects (aged ≥ 60 yea...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-019-01012-0
更新日期：2019-11-01 00:00:00
abstract：:Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral ...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-010-0213-0
更新日期：2011-03-01 00:00:00
abstract：:The aim of this study was to evaluate the prevalence of spine–femur discordance, and to compare the effectiveness of femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) for estimation of the risk of vertebral fractures. Women who were evaluated with dual energy X-ray absorptiometry between January 2001 ...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-013-0512-3
更新日期：2014-07-01 00:00:00
abstract：INTRODUCTION:Very few studies have been performed to evaluate both the severity and site of aortic calcification (AC) in both end-stage kidney disease (ESKD) and diabetes mellitus (DM). The purpose of our study was to examine the utility of a newly developed three-dimensional (3D) visualization and quantification metho...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-020-01172-4
更新日期：2020-11-03 00:00:00
abstract：:To screen a potential risk factor for femoral neck fracture, we characterized lumbar vertebral fractures in 120 patients with femoral neck fractures (19 men, 101 women; mean age, 78.7 years) by investigating the frequency of patients with lumbar vertebral fracture, the number of vertebral fractures per patient, and th...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s007740050085
更新日期：1999-01-01 00:00:00
abstract：:Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization. Preoperative administration of bisphosphonates, potent inhibitors of osteoclast activity, may prevent postoperative hypocalcem...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-005-0680-x
更新日期：2006-01-01 00:00:00
abstract：:The effects of unilateral sciatic neurectomy (USN) on the development of the femur were studied in 15 growing Wistar-derived rats (age, 5 weeks). The rats were divided into four groups: USN-operated group (right femur), USN-nonoperated group (left femur), sham-operated group (right femur), and sham-nonoperated group (...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s007740050093
更新日期：1999-01-01 00:00:00
abstract：:The G171V mutation (high bone mass, HBM) is autosomal dominant and is responsible for high bone mass in humans. Transgenic HBM mice in which the human LRP5 G171V gene is inserted also show a similar phenotype with greater bone mass and biomechanical performance than wild-type mice, as determined by whole bone testing....
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-010-0194-z
更新日期：2011-01-01 00:00:00
abstract：:In 50 premenarcheal girls selected from the lowest and highest end of the calcium-intake distribution of a large population sample, we evaluated bone mineral density (BMD), together with the following hormonal-metabolic parameters: androstenedione (ASD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (D...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-003-0451-5
更新日期：2004-01-01 00:00:00
