Abstract:
:Hippocampal-dependent cognitive functions rely on production of new neurons and maintenance of dendritic structures to provide the synaptic plasticity needed for learning and formation of new memories. Hippocampal formation is exquisitely sensitive to patho-physiological changes, and reduced antioxidant capacity and exposure to low dose irradiation can significantly impede hippocampal-dependent functions of learning and memory by reducing the production of new neurons and alter dendritic structures in the hippocampus. Although the mechanism leading to impaired cognitive functions is complex, persistent oxidative stress likely plays an important role in the SOD-deficient and radiation-exposed hippocampal environment. Aging is associated with increased production of pro-oxidants and accumulation of oxidative end products. Similar to the hippocampal defects observed in SOD-deficient mice and mice exposed to low dose irradiation, reduced capacity in learning and memory, diminishing hippocampal neurogenesis, and altered dendritic network are universal in the aging brains. Given the similarities in cellular and structural changes in the aged, SOD-deficient, and radiation-exposed hippocampal environment and the corresponding changes in cognitive decline, understanding the shared underlying mechanism will provide more flexible and efficient use of SOD deficiency or irradiation to model age-related changes in cognitive functions and identify potential therapeutic or intervention methods.
journal_name
Arch Biochem Biophysjournal_title
Archives of biochemistry and biophysicsauthors
Huang TT,Leu D,Zou Ydoi
10.1016/j.abb.2015.03.014subject
Has Abstractpub_date
2015-06-15 00:00:00pages
2-7eissn
0003-9861issn
1096-0384pii
S0003-9861(15)00142-3journal_volume
576pub_type
杂志文章,评审abstract::The subcellular mechanism of alkenyl halide S-conjugate-induced nephrotoxicity was studied in mitochondria isolated from rat kidney cortex in vitro using the cysteine conjugate of hexachloro-1,3-butadiene, i.e., S-pentachlorobutadienyl-L-cysteine (PCBC) as a model substrate. Respiring mitochondria exposed to various c...
journal_title:Archives of biochemistry and biophysics
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pub_type: 杂志文章,评审
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journal_title:Archives of biochemistry and biophysics
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journal_title:Archives of biochemistry and biophysics
pub_type: 杂志文章
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更新日期:2015-05-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1006/abbi.1993.1332
更新日期:1993-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-04-01 00:00:00
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journal_title:Archives of biochemistry and biophysics
pub_type: 杂志文章
doi:10.1006/abbi.1993.1277
更新日期:1993-06-01 00:00:00
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journal_title:Archives of biochemistry and biophysics
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1994-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2004-09-15 00:00:00
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pub_type: 杂志文章
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更新日期:1986-02-01 00:00:00
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journal_title:Archives of biochemistry and biophysics
pub_type: 杂志文章
doi:10.1016/0003-9861(92)90126-h
更新日期:1992-10-01 00:00:00