Abstract：
:Using immunoassay and immunoblotting approaches, antibodies to Sj26, a glutathione S-transferase molecule (Mr = 26,000) of Schistosoma japonicum worms that is a vaccine candidate, have been sought in three large human serum banks. For these studies, a near-native recombinant Sj26 molecule produced in Escherichia coli was used, generally in ELISAs. Anti-Sj26 activity was detected readily in a high proportion of the sera at titres below 1:400 and appeared to be largely protein A-binding IgG antibodies. No differences in the prevalence of anti-Sj26 antibodies were noted in sera from entirely normal individuals or those with a variety of parasitic infections, but never exposed to S. japonicum. The stimulus responsible for induction of these low titre, probably low affinity antibodies in humans remains unknown.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Lightowlers MW,Mitchell GFdoi
10.1016/0001-706x(89)90023-5subject
Has Abstractpub_date
1989-07-01 00:00:00pages
229-38issue
4eissn
0001-706Xissn
1873-6254pii
0001-706X(89)90023-5journal_volume
46pub_type
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