Abstract：
:The emergence of resistance to albendazole has encouraged the search for effective alternatives for cysticercosis and other parasitosis treatment. RCB15 is a benzimidazole derivative that may be used against such diseases. The aim of this study was to determine the in vitro effect of RCB15 on the alternative energetic pathways of Taenia crassiceps cysticerci. The cysticerci were in vitro exposed to albendazole sulphoxide (ABZSO) or RCB15 at different concentrations during 24h. The cysticerci extract and the culture medium were analyzed through spectrophotometry and high performance liquid chromatography as to detect glucose, urea, creatinine and organic acids of the energetic metabolism. The drugs did not influence the protein catabolism. Fatty acids oxidation was enhanced through significantly higher acetate concentrations in the groups treated with RCB15 and ABZSO. Beta-hydroxybutyrate concentrations were decreased which indicates the use of fatty acids towards acetyl-CoA synthesis. There was a decrease in glucose uptake and pyruvate concentrations. The absence of lactate indicates the use of pyruvate in gluconeogenesis. Therefore it is possible to conclude that RCB15 enhanced the alternative energetic pathways of cysticerci in vitro exposed to different concentration, with emphasis on the fatty acids catabolism.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
de Andrade Picanço G,de Lima NF,Fraga CM,da Costa TL,Isac E,Ambrosio J,Castillo R,Vinaud MCdoi
10.1016/j.actatropica.2017.08.022subject
Has Abstractpub_date
2017-12-01 00:00:00pages
288-292eissn
0001-706Xissn
1873-6254pii
S0001-706X(17)30757-Xjournal_volume
176pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract：:Definitions of the term 'challenge' as applied to the African trypanosomiases are reviewed. Data from one West and one East African site show simple linear relationships between the incidence of trypanosomiasis in both humans and animals, and either the amount of man-tsetse contact, or the Apparent Density of flies. D...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：
更新日期：1985-03-01 00:00:00
abstract：:In addition to genetic history, environmental conditions during larval stages are critical to the development, success and phenotypic fate of the Aedes aegypti mosquito. In particular, previous studies have shown a strong genotype-by-environment component to adult mosquito body size in response to optimal vs stressed ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.06.018
更新日期：2017-10-01 00:00:00
abstract：:The rat lungworm Angiostrongylus cantonensis causes human eosinophilic meningitis and it is endemic in Southeast Asia, but little is known about its distribution in Laos, Cambodia and Vietnam. We conducted a multi-country survey for A. cantonensis in these countries to estimate its prevalence in snails along the Mekon...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.03.021
更新日期：2018-07-01 00:00:00
abstract：:This study was conducted to determine the effects of increased water temperatures on the development of Aedes aegypti immatures under laboratory conditions in Trinidad, West Indies using temperature regulated water baths to cover a range of temperatures from 24-25°C to 34-35°C at a relative humidity of 80%. Two experi...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2011.04.004
更新日期：2011-07-01 00:00:00
abstract：:Mosquitoes are vectors of many human diseases. In particular, Aedes ægypti (Linnaeus) is the main vector for Chikungunya, Dengue, and Zika viruses in Latin America and it represents a global threat. Public health policies that aim at combating this vector require dependable and timely information, which is usually exp...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.05.003
更新日期：2018-09-01 00:00:00
abstract：:A study of the natural infection of phlebotomine sand flies by Leishmania (Leishmania) infantum was conducted in an area of visceral leishmaniasis in São Vicente Férrer, located in the northern part of the Atlantic rain forest region in the State of Pernambuco, Brazil. In a previous study, Migonemyia migonei have been...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2010.03.009
更新日期：2010-10-01 00:00:00
abstract：:Toxoplasmosis is a widespread, neglected disease with significant morbidity and mortality. In search of an effective treatment, nitazoxanide (NTZ) was evaluated in the treatment of acute and chronic toxoplasmosis in experimental mice. For this purpose, mice were infected with 20 cysts (acute infection model) or 10 cys...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.04.013
更新日期：2019-07-01 00:00:00
abstract：:Culex mosquitoes can act as vectors of several important diseases, including Japanese encephalitis, West Nile virus, St. Louis encephalitis and equine encephalitis. Besides the neurological sequelae caused in humans, Japanese encephalitis can lead to abortion in sows and encephalitis in horses. Effective vector contro...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.04.006
更新日期：2018-07-01 00:00:00
abstract：:A large-scale control trial against Glossina palpalis palpalis was carried out in the Congo using a new trapping technique. In the same way a test related to the experimental utilization of sentinel animals was performed, concurrently to the classical epidemiological and entomological evaluation. 564 domestic animals ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：:The persistence of Trypanosoma cruzi in seropositive individuals, previously diagnosed as chronic chagasic patients (CCP), was detected for the first time in biopsies taken from gingival inflammatory foci processed by polymerase chain reaction (PCR). Seven out of 31 (22.5%) gum samples from selected unquestionably CCP...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2010.12.010
更新日期：2011-03-01 00:00:00
abstract：:Proteins in Schistosoma haematobium infected human urine were concentrated by precipitation with saturated ammonium sulphate 50% (v/v) and various fractions obtained at different stages of precipitation tested for presence of schistosome antigens (ShAgs) by dot-ELISA. The protein fraction (UP2S) obtained following two...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(96)00040-x
更新日期：1996-10-01 00:00:00
abstract：:Trypanosoma rangeli, a non-pathogenic hemoflagelate that in Central and South America infects humans, shares with Trypanosoma cruzi reservoirs and triatomine vectors, as well as geographical distribution. Recently, we have described in T. rangeli a truncated gene copy belonging to the group II of the trans-sialidase s...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2009.05.003
更新日期：2009-09-01 00:00:00
abstract：:We studied breeding sites of Phlebotomus orientalis (Diptera: Psychodidae) the vector of visceral leishmaniasis in northern Ethiopia. Although numbers were rather small, 165 sand flies were captured emerging from vertisol cracks. The most productive breeding sites were cracked vertisols, dry river banks and close to t...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.06.013
更新日期：2014-11-01 00:00:00
abstract：:Improving immunization coverage is vital to promoting child health and reducing childhood diseases and deaths. In spite of being actively promoted as a major public health intervention for national development since the late 1970s, immunization coverage in Ghana remains low. We investigated factors that influence atte...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(97)00094-6
更新日期：1997-12-01 00:00:00
abstract：:Theileria annulata schizont transformed bovine lymphocytes show the feature of permanent proliferation in vitro culture. In this study, we optimized a suitable culture medium for transformed cells to ensure a high yield of quality cells in suspension culture. As the basis for the optimized medium, we combined 75% Gibc...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.105237
更新日期：2020-02-01 00:00:00
abstract：:Using immunoassay and immunoblotting approaches, antibodies to Sj26, a glutathione S-transferase molecule (Mr = 26,000) of Schistosoma japonicum worms that is a vaccine candidate, have been sought in three large human serum banks. For these studies, a near-native recombinant Sj26 molecule produced in Escherichia coli ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/0001-706x(89)90023-5
更新日期：1989-07-01 00:00:00
abstract：BACKGROUND:Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF patients living in southeastern Brazil. PURPOSE:To georeference the distribution of Simuliidae (Dipt...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.09.015
更新日期：2017-12-01 00:00:00
abstract：:"Anomalous", as yet unreported forms of brood capsules (BC) in cystic echinococcosis larvae from humans and sheep are described, thought to be the likely effect of degenerative involution of the parasite. Morphological examination showed an inner laminated layer (LL) in the brood capsules in intimate contact with the ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2007.12.006
更新日期：2008-03-01 00:00:00
abstract：:Crimean-Congo hemorrhagic fever (CCHF) is one of the most important public health threats in many regions across Africa, Europe, and Asia. This study used ecological niche modeling analyses to map the environmental suitability of both CCHF virus (CCHFV), and its tick vectors (Amblyomma variegatum, Dermacentor marginat...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.105319
更新日期：2020-03-01 00:00:00
abstract：:Cell lysates from 16 strains of eight Leishmania species were used to test haemagglutination activity (HA) against a variety of RBC. HA was detected using native or neuraminidase-treated rabbit RBC; it was found in promastigotes of all the Leishmania strains tested and in axenic amastigotes of L. mexicana. The HA was ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(97)00069-7
更新日期：1997-10-14 00:00:00
abstract：:By using the criteria that define emerging infectious diseases (EIDs) of humans, we can identify a similar group of EIDs in wildlife. In the current review we highlight an important series of wildlife EIDs: amphibian chytridiomycosis; diseases of marine invertebrates and vertebrates and two recently-emerged viral zoon...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/s0001-706x(00)00179-0
更新日期：2001-02-23 00:00:00
abstract：:The complete life cycle of the trematode Ascocotyle (Phagicola) longa (Digenea: Heterophyidae) is elucidated by natural observation validated by experimental infections. The natural first intermediate host of A. (P.) longa, an agent of human heterophyiasis in Brazil, is the cochliopid snail Heleobia australis (new fir...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2009.10.020
更新日期：2010-03-01 00:00:00
abstract：:With the paradigm shift from the reduction of morbidity and mortality to the interruption of transmission, the focus of malaria control broadens from symptomatic infections in children ≤5 years of age to include asymptomatic infections in older children and adults. In addition, as control efforts intensify and the num...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2011.11.009
更新日期：2012-03-01 00:00:00
abstract：:The salivary glands of insect's vectors are target organs to study the vectors-pathogens interactions. Rhodnius prolixus an important vector of Trypanosoma cruzi can also transmit Trypanosoma rangeli by bite. In the present study we have investigated ecto-phosphatase activity on the surface of R. prolixus salivary gla...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.02.008
更新日期：2008-05-01 00:00:00
abstract：:Historically, the whole of Burkina Faso was considered to be endemic for onchocerciasis (except a small area in the far north of the country) with prevalence rates 60-80%, but all endemic areas were included in the World Health Organisation Onchocerciasis Control Programme, which operated a system of vector control by...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.05.013
更新日期：2018-09-01 00:00:00
abstract：:We assessed the diversity and distribution of Trypanosoma cruzi discrete typing units (DTU) in Triatoma infestans populations and its association with local vector-borne transmission levels at various geographic scales. At a local scale, we found high predominance (92.4%) of TcVI over TcV in 68 microscope-positive T. ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2014.07.014
更新日期：2014-12-01 00:00:00
abstract：:Foodborne intestinal flukes are highly diverse consisting of at least 74 species with a diverse global distribution. Taxonomically they include 28 species of heterophyids, 23 species of echinostomes, and 23 species of miscellaneous groups (amphistomes, brachylaimids, cyathocotylids, diplostomes, fasciolids, gymnophall...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2019.105210
更新日期：2020-01-01 00:00:00
abstract：:Glugea eda n. sp. is described from the mesenteries of the striated fusilier, Caesio striata, collected from the Red Sea coast off Yanbu' al Bahr, Saudi Arabia. Numerous blackish xenomas, ranged from 3 to 5 mm, were found in the body cavity associated with the mesenteries. Mature spores are monomorphic, ellipsoidal wi...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105331
更新日期：2020-04-01 00:00:00
abstract：:Heme (iron protoporphyrin IX) is an important molecule involved in many biological reactions, including oxygen transport, respiration, photosynthesis and drug detoxification. Trypanosoma cruzi parasites, the etiological agent of Chagas' disease, take up heme from the environment to supply their nutritional needs becau...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2011.08.011
更新日期：2011-12-01 00:00:00
abstract：:The emergence of drug-resistance poses a major obstacle to the control of malaria. A homolog of the major multidrug-transporter in mammalian cells was identified, Plasmodium falciparum multidrug resistance protein-1, pfmdr1, also known as the P-glycoprotein homolog 1, Pgh-1. Several studies have demonstrated strong, a...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2005.04.008
更新日期：2005-06-01 00:00:00
