Abstract：
INTRODUCTION:HLA-G plays a key role on immune tolerance. Pathogens can induce soluble HLA-G (sHLA-G) production to down-regulate the host immune response, creating a tolerogenic environment favorable for their dissemination. To our knowledge, no study has yet been conducted to assess the relationship between sHLA-G and geohelminth infections. METHODS:The study was conducted in Allada, Southeastern Benin, from 2011-2014. The study population encompassed 400 pregnant women, included before the end of the 28th week of gestation and followed-up until delivery. At two antenatal care visits and at delivery, stool and blood samples were collected. Helminths were diagnosed by means of the Kato-Katz concentration technique. We used quantile regression to analyze the association between helminth infections and sHLA-G levels during pregnancy. RESULTS:sHLA-G levels gradually increased during pregnancy and reached maximal levels at delivery. Prevalence of helminth infections was low, with a majority of hookworm infections. We found significantly more hookworm-infected women above the 80th quantile (Q80) of the distribution of the mean sHLA-G level (p < 0.03, multivariate quantile regression). Considering only women above the Q80 percentile, the mean sHLA-G level was significantly higher in hookworm-infected compared to uninfected women (p = 0.04). CONCLUSION:High levels of sHLA-G were associated with hookworm infection in pregnant women. This result is consistent with the potential involvement of sHLA-G in immune tolerance induced by helminths during pregnancy.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Avokpaho E,d'Almeida TC,Sadissou I,Tokplonou L,Adamou R,Sonon P,Milet J,Cottrell G,Mondière A,Massougbodji A,Moutairou K,Donadi EA,Teixeira Mendes Junior C,Favier B,Carosella E,Moreau P,Rouas-Freiss N,Garcia A,Courtindoi
10.1016/j.actatropica.2019.04.026subject
Has Abstractpub_date
2019-08-01 00:00:00pages
52-59eissn
0001-706Xissn
1873-6254pii
S0001-706X(18)30327-9journal_volume
196pub_type
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