Abstract:
:Methoxyfenozide, an ecdysone receptor agonist is an effective larvicide against many pests of public health and veterinary importance including house fly, Musca domestica L. (Diptera: Muscidae). Methoxyfenozide is a bio-rational insecticide having many environmentally friendly attributes that make it compatible with integrated pest management programs. This experiment was performed for the assessment of resistance evolution in M. domestica to methoxyfenozide. A field population of M. domestica, after 24 rounds of selection with methoxyfenozide, resulted in 64 fold and 915-fold increase in lethal concentration 50 (LC50) compared to field and susceptible strain, respectively. Realized heritability (h(2)) of resistance to methoxyfenozide was 0.17 in methoxyfenozide-selected strain of M. domestica. The projected rate of resistance development indicated that, if slope=1.71 and h(2)=0.17, then 13-5 generations are required for tenfold increase in LC50 at 50-95% selection intensity. These findings suggest that a risk for resistance development to methoxyfenozide occurred in M. domestica under continuous selection pressure.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Shah RM,Abbas N,Shad SAdoi
10.1016/j.actatropica.2015.05.009subject
Has Abstractpub_date
2015-09-01 00:00:00pages
32-7eissn
0001-706Xissn
1873-6254pii
S0001-706X(15)30002-4journal_volume
149pub_type
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