Abstract：
:Infection with the protozoan parasite Trypanosoma cruzi, the etiologic agent of human Chagas disease, results in life-long infection. Infective trypomastigotes circulate in the bloodstream and have the capacity to infect any cell type, including reproductive tissue. This study sought to assess the potential for sexual transmission of T. cruzi in an experimental mouse model. The conditions used in this study, in which acutely infected males and immunosuppressing the females, created a worst-case scenario allowing for the greatest chance of measuring transmission through intercourse. Male BALB/c mice were infected and mated with uninfected females, and the females were subsequently examined for T. cruzi tissue parasitism. A single transmission event of 61 total matings was observed, indicating a low but non-zero risk potential for male-to-female sexual transmission of T. cruzi.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Martin DL,Lowe KR,McNeill T,Thiele EA,Roellig DM,Zajdowicz J,Hunter SA,Brubaker SAdoi
10.1016/j.actatropica.2015.05.002subject
Has Abstractpub_date
2015-09-01 00:00:00pages
15-8eissn
0001-706Xissn
1873-6254pii
S0001-706X(15)00136-9journal_volume
149pub_type
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