Abstract:
:In summary, there is much overlap among the three types of localized cutaneous pemphigoid discussed. They all tend to affect the same age group, in general. They all may remain regional or be associated with a generalized eruption consistent with bullous pemphigoid. These three variants of subepidermal blistering disease also appear to be susceptible to koebnerization. Direct immunofluorescence findings are identical, as well, with linear IgG and C3 at the basement membrane. Indirect immunofluorescence tends to be negative for all three variants, with a tendency to positivity with increased extent and severity of skin involvement. There are differences, though, between them. BPP tends to affect men more than women, unlike BMMP-CP and localized cutaneous nonscarring BP. Localized cutaneous nonscarring BP usually involves the legs, whereas the other two conditions affect the head and neck, with resultant scarring. Histology is similar to that seen in BP, but dermal fibrosis and sclerosis result in skin affected by BMMP-CP and BPP. Localized cutaneous nonscarring BP is more amenable to topical steroid therapy, whereas BMMP-CP and BPP are more persistent and resistant to systemic immunosuppressive therapy. Clinical, histologic, and immunologic similarities among the pemphigoid variants may reflect common antigenic features. On the other hand, clinical, histologic, and immunologic differences may imply that there are more than one bullous pemphigoid antibody directed at a variety of antigenic structures.
journal_name
Clin Dermatoljournal_title
Clinics in dermatologyauthors
Kaplan RPdoi
10.1016/0738-081x(87)90048-4subject
Has Abstractpub_date
1987-01-01 00:00:00pages
43-51issue
1eissn
0738-081Xissn
1879-1131pii
0738-081X(87)90048-4journal_volume
5pub_type
杂志文章,评审abstract::Urticaria is one of the most common diseases seen in everyday dermatologic practice, characterized by the development of wheals, angioedema, or both. While acute urticaria is mostly related to allergic or pseudoallergic reaction to food, drugs, or infections, chronic urticaria is a more complex disease with different ...
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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abstract::Mucocutaneous diseases and conditions, including aging, are known to be the result of multiple pathophysiologic anomalies induced by various environmental insults. Creating therapeutic products for these multifactorial diseases and conditions is challenging. Although safety testing is not required for cosmetics and co...
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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journal_title:Clinics in dermatology
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