[Myopathy due to succinate cytochrome C oxidoreductase deficiency: possible defect of complex II of the respiratory chain].

Abstract:

:The case of a 24 years-old woman with weakness since the teens and progressive loss of muscle strength is reported. The muscle biopsy showed increased number of mitochondria. In two occasions the respiratory chain enzymes showed important reduction of the succinate-cytochrome-C-reductase, suggesting a possible defect in the complex II of the respiratory chain. Large doses of vitamins C and K were prescribed. There was improvement of muscle strength. A discussion about the most common syndromes marked by mitochondrial abnormalities in muscle is made, as well as about the type of work-up that should be done in suspect cases of respiratory chain defects.

journal_name

Arq Neuropsiquiatr

authors

Werneck LC,DiMauro S

doi

10.1590/s0004-282x1989000400013

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

461-7

issue

4

eissn

0004-282X

issn

1678-4227

journal_volume

47

pub_type

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