Magnetic resonance imaging study cannot individually distinguish individuals with mild cognitive impairment, mild Alzheimer's disease, and normal aging.

Abstract:

OBJECTIVE:To evaluate the volumetric and spectroscopy aspects of hippocampus in patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI). METHODS:A series of patients older than 65 years and with memory deficit were studied. RESULTS:The evocation of words test presented a significant reduction in the number of words recalled by the patients with MCI and mild AD as compared with the control group. Bilateral reduction of the hippocampus volume in the AD group was observed when compared to the control group. There were no statistical differences in the values of NAA/Cr, mI/Cr, Cho/Cr and mI/NAA between the groups. CONCLUSIONS:Magnetic resonance imaging study failed to individually distinguish patients with MCI, mild AD and normal aging. However, patients with mild AD presented loss of asymmetry between the right and left hippocampus, and a reduction in hippocampus volume.

journal_name

Arq Neuropsiquiatr

authors

Menezes TL,Andrade-Valença LP,Valença MM

doi

10.1590/0004-282x20130003

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

207-12

issue

4

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2013000400207

journal_volume

71

pub_type

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