Long term follow-up of growth hormone-secreting pituitary adenomas submitted to endoscopic endonasal surgery.

Abstract:

Objective:The aim of this study was to evaluate the results of the endoscopic transsphenoidal technique for growth hormone (GH)-secreting adenomas. Methods:A retrospective analysis based on medical records of 23 acromegalic patients submitted to endoscopic transsphenoidal surgery. Biochemical control was defined as basal GH < 1ng/ml, nadir GH < 0.4ng/ml after glucose load and age-adjusted IGF-1 normal at the last follow-up. Results:The overall endocrinological remission rate was 39.1%. While all microademonas achieved a cure, just one third of macroadenomas went into remission. Suprasellar extension, cavernous sinus invasion and high GH levels were associated with lower rates of disease control. The most common complication was diabetes insipidus and the most severe was an ischemic stroke. Conclusion:The endoscopic transsphenoidal approach is a safe and effective technique to control GH-secreting adenomas. The transcavernous approach may increase the risk of complications. Suprasellar and cavernous sinus extensions may preclude gross total resection of these tumors.

journal_name

Arq Neuropsiquiatr

authors

Leopoldo CMDS,Leopoldo FMDS,Santos ARLD,Veiga JCE,Lima JV Junior,Scalissi NM,Lazarini PR,Dolci RLL

doi

10.1590/0004-282X20170035

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

301-306

issue

5

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2017000500301

journal_volume

75

pub_type

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