High phenotypic variability in Gerstmann-Sträussler-Scheinker disease.

Abstract:

:Gerstmann-Sträussler-Scheinker is a genetic prion disease and the most common mutation is p.Pro102Leu. We report clinical, molecular and neuropathological data of seven individuals, belonging to two unrelated Brazilian kindreds, carrying the p.Pro102Leu. Marked differences among patients were observed regarding age at onset, disease duration and clinical presentation. In the first kindred, two patients had rapidly progressive dementia and three exhibited predominantly ataxic phenotypes with variable ages of onset and disease duration. In this family, age at disease onset in the mother and daughter differed by 39 years. In the second kindred, different phenotypes were also reported and earlier ages of onset were associated with 129 heterozygosis. No differences were associated with apoE genotype. In these kindreds, the codon 129 polymorphism could not explain the clinical variability and 129 heterozygosis was associated with earlier disease onset. Neuropathological examination in two patients confirmed the presence of typical plaques and PrPsc immunopositivity.

journal_name

Arq Neuropsiquiatr

authors

Smid J,Studart A Neto,Landemberger MC,Machado CF,Nóbrega PR,Canedo NHS,Schultz RR,Naslavsky MS,Rosemberg S,Kok F,Chimelli L,Martins VR,Nitrini R

doi

10.1590/0004-282X20170049

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

331-338

issue

6

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2017000600331

journal_volume

75

pub_type

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