Multiple sclerosis outcome and morbi-mortality of a Brazilian cohort patients.

Abstract:

:We studied the clinical and evolution characteristics of multiple sclerosis (MS) patients followed since the onset of HUCFF/UFRJ in 1978. The diagnosis of MS was based on Poser's et al. and MC Donald's et al. criteria. From 188 patients, 122 were included. Eighty-five were females. The mean age onset was 32.2 years-old (range 6.0 to 61.0+/-10.3), mainly Caucasians (82/67%). The relapsing-remitting course (MSRR) was more frequent (106/86.8%). Monosymptomatic onset was significantly more frequent in Caucasians than in Afro-Brazilians (p<0.05). Seventeen patients had benign form of MS and these patients presented association with MSRR when compared with severe form (p=0.01). The mortality rate was 2.12% (4 patients died). This study was similar to other Brazilian series with regard to sex and age, and lack of correlation between EDSS and number of relapses; it confirmed south-southeast African-descendants gradient distribution and association between first mono-symptomatic relapses and Caucasian; we found lower frequency of benign forms.

journal_name

Arq Neuropsiquiatr

authors

Alves-Leon SV,Malfetano FR,Pimentel ML,Estrada CL,Pereira VC,Liem AM,Novis SA

doi

10.1590/s0004-282x2008000500012

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

671-7

issue

3B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2008000500012

journal_volume

66

pub_type

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