Multiple sclerosis outcome and morbi-mortality of a Brazilian cohort patients.


:We studied the clinical and evolution characteristics of multiple sclerosis (MS) patients followed since the onset of HUCFF/UFRJ in 1978. The diagnosis of MS was based on Poser's et al. and MC Donald's et al. criteria. From 188 patients, 122 were included. Eighty-five were females. The mean age onset was 32.2 years-old (range 6.0 to 61.0+/-10.3), mainly Caucasians (82/67%). The relapsing-remitting course (MSRR) was more frequent (106/86.8%). Monosymptomatic onset was significantly more frequent in Caucasians than in Afro-Brazilians (p<0.05). Seventeen patients had benign form of MS and these patients presented association with MSRR when compared with severe form (p=0.01). The mortality rate was 2.12% (4 patients died). This study was similar to other Brazilian series with regard to sex and age, and lack of correlation between EDSS and number of relapses; it confirmed south-southeast African-descendants gradient distribution and association between first mono-symptomatic relapses and Caucasian; we found lower frequency of benign forms.


Arq Neuropsiquiatr


Alves-Leon SV,Malfetano FR,Pimentel ML,Estrada CL,Pereira VC,Liem AM,Novis SA




Has Abstract


2008-09-01 00:00:00














  • Excessive daytime sleepiness in Campo Grande general population, Brazil.

    abstract::The prevalence of excessive daytime sleepiness (EDS) in general population was determined by means of 408 home interviews of adults, in a representative sample of Campo Grande city, Brazil. The random sample was stratified by sex, age and economic social status. EDS was considered in those with indexes 11 or more in t...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Souza JC,Magna LA,Reimao R

    更新日期:2002-09-01 00:00:00

  • Imipramine for vestibular dysfunction in panic disorder: a prospective case series.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the efficacy and effectiveness of imipramine on the treatment of comorbid chronic dizziness and panic disorder. METHOD:Nine patients with panic disorder and agoraphobia associated with chronic dizziness underwent otoneurological screening and were treated with a 3-mo...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Mezzasalma MA,Mathias Kde V,Nascimento I,Valença AM,Nardi AE

    更新日期:2011-04-01 00:00:00

  • A clinical approach to hypertrophic pachymeningitis.

    abstract:IMPORTANCE:Hypertrophic pachymeningitis (HP) is a non-usual manifestation of rheumatologic, infectious, and neoplastic diseases. Etiological diagnosis is a challenge, but when made promptly it creates a window of opportunity for treatment, with the possibility of a total reversal of symptoms. OBSERVATIONS:HP is an inf...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Abrantes FF,Moraes MPM,Rezende Filho FM,Pedroso JL,Barsottini OGP

    更新日期:2020-12-01 00:00:00

  • The role of sleep in migraine attacks.

    abstract::Migraine attacks may be precipitated by sleep deprivation or excessive sleep and sleep is also associated with relief of migraine attacks. In view of this variable relationship we studied the records of 159 consecutive outpatients of our Headache Unit. In 121 records there was reference to sleep involvement, in 55% by...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Inamorato E,Minatti-Hannuch SN,Zukerman E

    更新日期:1993-12-01 00:00:00

  • NMO in pediatric patients: brain involvement and clinical expression.

    abstract:OBJECTIVE:To analyze the clinical, neuroimaging characteristics and positivity of the acquaporin water channel (NMO-IgG) in pediatric patients with neuromyelitis optica (NMO). This disorder could have a variable clinical expression. To address such variability, the term NMO spectrum has been suggested. METHOD:We evalu...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Peña JA,Ravelo ME,Mora-La Cruz E,Montiel-Nava C

    更新日期:2011-02-01 00:00:00

  • Neurodegenerative changes in the brainstem and olfactory bulb in people older than 50 years old: a descriptive study.

    abstract::With the increase in life expectancy in Brazil, concerns have grown about the most prevalent diseases in elderly people. Among these diseases are neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Protein deposits related to the development of these diseases can pre-date the symptomatic phases b...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Oliveira FH,Rodrigues Neto E,Fonseca MK,Costa AS,Rockenbach MA,Padilha Rdos S,Fernandez LL,Hilbig A

    更新日期:2015-07-01 00:00:00

  • [Familial spastic paraplegia with amyotrophy. Clinical, electromyographic, histochemical study and microdissection].

    abstract::Four cases of familial spastic paraplegia with amyotrophy in siblings from a consanguineous married are reported. The routine laboratory examination were normal. The electromiography and muscle biopsy processed by histochemistry showed signs of denervation with reinervation. The motor nerve conduction velocity was dec...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Werneck LC,Sanches MC

    更新日期:1979-06-01 00:00:00

  • [Tonic epileptic crisis and complex and mixed atypical absences in Lennox-Gastaut syndrome in patients over 6 years of age].

    abstract::Complex and mixed atypical absences and tonic epileptic seizures of 12 patients with the Lennox-Gastaut syndrome with onset after age 6 were studied. By complexes seizures we mean the associations of two elementary epileptics phenomena and by mixed that of three or more. Complex and mixed epileptic seizures already re...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Barreira AA,Lison MP,Speciali JG

    更新日期:1982-12-01 00:00:00

  • Menstrual cycle worsening of epileptic seizures in women with symptomatic focal epilepsy.

    abstract:INTRODUCTION:Hormonal fluctuation is responsible for worsening of epileptic seizures during the menstrual cycle. OBJECTIVE:To identify irregularities in the menstrual cycles of women with mesial temporal lobe epilepsy (MTLE) and extratemporal focal epilepsy (ETFE) and correlate the frequency of seizures during the men...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Bazán AC,Montenegro MA,Cendes F,Min LL,Guerreiro CA

    更新日期:2005-09-01 00:00:00

  • Mitochondrial myopathy with respiratory muscle involvement: a case report.

    abstract::A case of a 10-year-old patient with a benign congenital myopathy, suddenly aggravated because of an accentuated deficit in respiratory muscles is reported. The institution of assisted respiration at night allowed the patient to return to her daily activities. Examination of muscular biopsy with ultra-microscope permi...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Levy JA,Tsanaclis AM,Saraiva PA,Mion CC,Salum PN

    更新日期:1983-03-01 00:00:00

  • Impaired cognition in depression and Alzheimer (AD): a gradient from depression to depression in AD.

    abstract:OBJECTIVE:To assess cognition in major depressed (MD), Alzheimer's disease (AD), and depression in AD elderly. METHOD:Subjects were evaluated by Mini Mental, Rey Auditory Verbal Learning Test, Rey Complex Figure, Digit Span, Similarities, Trail Making A/B, Verbal Fluency and Stroop. One-way ANOVA and multivariate mode...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Araujo NB,Moraes HS,Silveira H,Arcoverde C,Vasques PE,Barca ML,Knapskog AB,Engedal K,Coutinho ES,Deslandes AC,Laks J

    更新日期:2014-09-01 00:00:00

  • [Diagnosis and treatment of associated epilepsy and psychogenic pesudoepileptic seizures: case report].

    abstract::We report on a case of a 26 year old patient with seizures since the age of 13, who was sent to our service for differential diagnosis between epilepsy and psychogenic pesudoepileptic seizures. Both diagnoses were confirmed and she was operated for the resection of an occipital cystic tumour, that was considered respo...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Marchetti RL,Kurcgant D

    更新日期:2001-06-01 00:00:00

  • The intercostobrachial nerve as a sensory donor for hand reinnervation in brachial plexus reconstruction is a feasible technique and may be useful for restoring sensation.

    abstract:Objective:Few donors are available for restoration of sensibility in patients with complete brachial plexus injuries. The objective of our study was to evaluate the anatomical feasibility of using the intercostobrachial nerve (ICBN) as an axon donor to the lateral cord contribution to the median nerve (LCMN). Methods:...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Foroni L,Siqueira MG,Martins RS,Oliveira GP

    更新日期:2017-07-01 00:00:00

  • Extraneural metastases in medulloblastoma.

    abstract::Medulloblastoma is the most common childhood malignant tumor of central nervous system, but it may also occur in adults. It presents high invasive growth with spreading of tumor cells into the leptomeningeal space along the neuroaxis early in the course of the disease. Extraneural metastases are rare but frequently le...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Muoio VM,Shinjo SO,Matushita H,Rosemberg S,Teixeira MJ,Marie SK

    更新日期:2011-01-01 00:00:00

  • [Neuromuscular abnormalities in disuse, ageing and cachexia].

    abstract::Cachexia, ageing and disuse and their effects on the human and animals neuromuscular system are reviewed. Disuse induces reduction of muscle fibers (mainly II) diameter with peripheral myofibrils lost; there is no core-targetoid or even reduction on myophosphorilase activity, both typical of denervation; the acetylcho...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审


    authors: Kouyoumdjian JA

    更新日期:1993-09-01 00:00:00

  • [Intravenous therapy with methylprednisolone and cyclophosphamide in vasculitis of peripheral nervous system. Evaluation of 8 patients].

    abstract::The peripheral nervous system is frequently involved in systemic vasculitis and it may be helpful in the disease diagnosis. We report on eight patients: seven women and one man; five white, two black and one yellow; age mean 55.9 years; four had polyarteritis nodosa, one had systemic lupus erythematosus, one had isola...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Lino AM,Hirata MT,Baêta AM,Tsanaclis AM,Scaff M,Marchiori PE

    更新日期:1998-06-01 00:00:00

  • [Multiple neuropaty caused by giant cell arteritis. Clinico-pathological report of a case].

    abstract::The case of a 67 years old woman with giant cell arteritis and neuritis multiplex is reported. The diagnosis was based on the microscopic appearances of temporal artery biopsy specimens. The authors described the involvement of peripheral nerves in this disease and made differential diagnosis with polyarteritis nodosa...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Moreira Filhio PF,de Freitas MR,Caldas ML,Almeida E

    更新日期:1978-09-01 00:00:00

  • Reliability and safety of a new upper cervical spine injury treatment algorithm.

    abstract:Methods:Thirty cases, previously treated according to the new algorithm, were presented to four spine surgeons who were questioned about their personal suggestion for treatment, and the treatment suggested according to the application of the algorithm. After four weeks, the same questions were asked again to evaluate r...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Joaquim AF,Brock RS,Guirado VM,Sandon LH,Silva OT,Taricco MA,Teixeira MJ,Figueiredo EG

    更新日期:2017-02-01 00:00:00

  • [Sexuality. A freudian psychoanalytical concept].

    abstract::Emphasis is placed in the difficulty in conceptualizing sexuality as a complex and controversial subject. This is a presentation of a concept based on freudian psychoanalysis. With this in mind, many of Freud's references are collected from the Brazilian Standard Edition of the Complete Psychological Works of Sigmund ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Bearzoti P

    更新日期:1994-03-01 00:00:00

  • Cortisol, DHEA, and depression in the elderly: the influence of physical capacity.

    abstract:OBJECTIVE:Major depression have been associated with cortisol and dehydroepiandrosterone (DHEA) changes in old depressed patients. We examined the association between depression, cortisol, and DHEA, correcting for confounding variables, including physical capacity. In addition, the association between hormone levels an...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Moraes H,Deslandes A,Maciel-Pinheiro Pde T,Corrêa H,Laks J

    更新日期:2016-06-01 00:00:00

  • An association of central post-stroke pain and thalamic hand.

    abstract::Thalamic hand is one of the clinical expressions of the painful thalamic syndrome. This paper relates on a case of a patient with a syndrome of central post-stroke and supra-thalamic pain who also presents a thalamic hand. The authors emphasize the notion that in the syndrome of central post-stroke pain a direct or in...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: de Castro-Costa CM,do Vale OC,Siqueira Neto JI

    更新日期:1992-03-01 00:00:00

  • What's in a name? Problems, facts and controversies regarding neurological eponyms.

    abstract::The use of eponyms in neurology remains controversial, and important questions have been raised about their appropriateness. Different approaches have been taken, with some eponyms being excluded, others replaced, and new ones being created. An example is Hallervorden-Spatz syndrome, which has been replaced by neurode...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 历史文章,杂志文章,评审


    authors: Teive HA,Lima PM,Germiniani FM,Munhoz RP

    更新日期:2016-05-01 00:00:00

  • Brazilian guidelines for the application of transcranial ultrasound as a diagnostic test for the confirmation of brain death.

    abstract::Neurosonological studies, specifically transcranial Doppler (TCD) and transcranial color-coded duplex (TCCD), have high level of specificity and sensitivity and they are used as complementary tests for the diagnosis of brain death (BD). A group of experts, from the Neurosonology Department of the Brazilian Academy of ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 指南,杂志文章


    authors: Lange MC,Zétola VH,Miranda-Alves M,Moro CH,Silvado CE,Rodrigues DL,Gregorio EG,Silva GS,Oliveira-Filho J,Perdatella MT,Pontes-Neto OM,Fábio SR,Avelar WM,Freitas GR,Task Force Group of the Neurosonology Department, Brazilian A

    更新日期:2012-05-01 00:00:00

  • Obstructive sleep apnea and Parkinson's disease: characteristics and associated factors.

    abstract::Obstructive sleep apnea (OSA) occurs in up to 66% of Parkinson's disease (PD) patients, higher than in the general population. Although it is more prevalent, the relationship between OSA and PD remains controversial, with some studies confirming and others denying the relationship of OSA with some risk factors and sym...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Sobreira-Neto MA,Pena-Pereira MA,Sobreira EST,Chagas MHN,Almeida CMO,Fernandes RMF,Tumas V,Eckeli AL

    更新日期:2019-09-23 00:00:00

  • [Coma and transtentorial herniation syndrome due to acute non-expansive hemispheric lesion].

    abstract::An 81-year-old woman developed left hemiplegia and coma due to a right hemisphere infarct and died 6 days later. When first seen in coma she had the classical signs of descending central herniation in the diencephalic stage. The CT scan of the third day showed a large hypodense area occupying the superficial and deep ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: De Oliveira-Souza R,Benchimol M

    更新日期:1995-12-01 00:00:00

  • Brazilian consensus on Duchenne muscular dystrophy. Part 1: diagnosis, steroid therapy and perspectives.

    abstract::Significant advances in the understanding and management of Duchenne muscular dystrophy (DMD) took place since international guidelines were published in 2010. Our objective was to provide an evidence-based national consensus statement for multidisciplinary care of DMD in Brazil. A combination of the Delphi technique ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,实务指引


    authors: Araujo APQC,Carvalho AAS,Cavalcanti EBU,Saute JAM,Carvalho E,França MC Junior,Martinez ARM,Navarro MMM,Nucci A,Resende MBD,Gonçalves MVM,Gurgel-Giannetti J,Scola RH,Sobreira CFDR,Reed UC,Zanoteli E

    更新日期:2017-08-01 00:00:00

  • Vascular parkinsonism: a case series of 17 patients.

    abstract:OBJECTIVE:To report the clinical and neuroimaging findings in a case series of vascular parkinsonism (VP). METHODS:Seventeen patients with VP were evaluated with motor, cognitive, and neuroimaging standardized tests and scales. RESULTS:All patients had arterial hypertension. Ten patients were male and the mean age of...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Vale TC,Caramelli P,Cardoso F

    更新日期:2013-10-01 00:00:00

  • Lumbar puncture in patients using anticoagulants and antiplatelet agents.

    abstract::The use of anticoagulants and antiplatelet agents has largely increased. Diagnostic lumbar puncture in patients taking these drugs represents a challenge considering the opposing risks of bleeding and thrombotic complications. To date there are no controlled trials, specific guidelines, nor clear recommendations in th...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审


    authors: Domingues R,Bruniera G,Brunale F,Mangueira C,Senne C

    更新日期:2016-08-01 00:00:00

  • [Developmental Gerstmann syndrome associated with cerebellar neoplasm. Report of a case and review of the literature].

    abstract::A Developmental Gerstmann syndrome in a 7 years-old-boy with hyperactivity, short attention span, acalculia, agraphia, right-left confusion, finger agnosia and constructional apraxia is reported. An initial trial with methylphenidate was done with good improvement regarding hyperactivity, attention span and constructi...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Werneck LC

    更新日期:1975-03-01 00:00:00

  • [De novo absence status: case report].

    abstract::There are few descriptions about middle-aged patients who have nonconvulsive status epilepticus, absence status. We reported the clinical case of a woman, 52-year-old, diabetic, referred to the emergency room in a confusional state. Initial electroencephalogram showed continuous typical, bilateral, symmetric and synch...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Tedrus GM,Fonseca LC,De Tella LM,Viana MA

    更新日期:1997-09-01 00:00:00