Expression of NMDA receptor and microRNA-219 in rats submitted to cerebral ischemia associated with alcoholism.

Abstract:

Objective::To evaluate the microRNA-219 and NMDA expression in brain tissue and blood of animals subjected to cerebral ischemia associated with alcoholism. Methods::Fifty Wistar rats were divided into groups: control, sham, ischemic, alcoholic, and ischemic plus alcoholic. The expression of microRNA-219 and NMDA were analyzed by real-time PCR. Results::When compared to the control group, the microRNA-219 in brain tissue was less expressed in the ischemic, alcoholic, and ischemic plus alcoholic groups. In the blood, this microRNA had lower expression in alcoholic and ischemic plus alcoholic groups. In the brain tissue the NMDA gene expression was greater in the ischemic, alcoholic, and ischemic plus alcoholic groups. Conclusion::A possible modulation of NMDA by microRNA-219 was observed with an inverse correlation between them.

journal_name

Arq Neuropsiquiatr

authors

Silva CI,Novais PC,Rodrigues AR,Carvalho CA,Colli BO,Carlotti CG Jr,Tirapelli LF,Tirapelli DP

doi

10.1590/0004-282X20160188

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

30-35

issue

1

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2017000100030

journal_volume

75

pub_type

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