Dementia pugilistica with clinical features of Alzheimer's disease.

Abstract:

:A 61-year-old ex-boxer presented with a three-year history of progressive memory decline. During a seven-year follow-up period, there was a continuous cognitive decline, very similar to that usually observed in Alzheimer's disease. Parkinsonian, pyramidal or cerebellar signs were conspicuously absent. Neuropathological examination revealed the typical features of dementia pugilistica: cavum septi pellucidi with multiple fenestrations, numerous neurofibrillary tangles in the cerebral isocortex and hippocampus (and rare senile plaques). Immunohistochemistry disclosed a high number of tau protein deposits and scarce beta-amyloid staining. This case shows that dementia pugilistica may present with clinical features practically undistinguishable from Alzheimer's disease.

journal_name

Arq Neuropsiquiatr

authors

Areza-Fegyveres R,Rosemberg S,Castro RM,Porto CS,Bahia VS,Caramelli P,Nitrini R

doi

10.1590/s0004-282x2007000500019

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

830-3

issue

3B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2007000500019

journal_volume

65

pub_type

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