[L-dopa, biperiden and sebum excretion in Parkinson disease].


:Sebum secretion was measured on the forehead of 47 patients with Parkinson's disease before and after treatment with anticholinergic (biperiden), levodopa + AAID and bromocriptine, by the osmic acid technique. Another 100 patients under biperiden, levodopa + AAID or association of both, for at least one year, were also evaluated. The male parkinsonian "de novo" patients have shown greater sebum secretion than female patients. It was also concluded that biperiden failed to reduce sebum secretion rate. On the other hand, it was found that L-dopa + AAID reduces the sebum secretion (CL = casual level and SER = sebum excretion rate) on both male and female patients. Bromocriptine (10mg/day) was the second dopaminergic therapy employed in the present work. Similarly to L-dopa, this dopaminergic agonist was able to significantly reduce sebum secretion (both CL and SER) of male patients. There was a positive and significant correlation for the 50-59 years old male patients "de novo" between CL and tremor, hypokinesia, gait and posture or functional incapacity, before treatment. After a period of treatment correlation was no more found. In relation to parkinsonians under chronic treatment was found a positive and significant correlation between sebum secretion and hypokinesia. The level of sebum secretion on parkinsonian "de novo" patients before treatment was equal to parkinsonian patients under chronic treatment regardless the treatment, except for greater than or equal to 60 years old parkinsonians who have shown CL and SER higher than "de novo" parkinsonian patients with the same age but without treatment. The treatment with L-dopa + AAID significantly decreased both CL and SER of "de novo" parkinsonian patients.(ABSTRACT TRUNCATED AT 250 WORDS)


Arq Neuropsiquiatr


Villares JC




Has Abstract


1989-03-01 00:00:00












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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Rodrigues MP,Naves LA,Casulari LA,Silva CA,Araújo RR,Viegas CA

    更新日期:2007-06-01 00:00:00

  • Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder.

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    journal_title:Arquivos de neuro-psiquiatria

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    更新日期:2012-02-01 00:00:00

  • [Migraine headache and syndrome of mitral valve prolapse. Report of 50 cases].

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    pub_type: 杂志文章


    authors: Cavalcanti CE,de Castro Júnior AN

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  • [Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300): a comparative study].

    abstract:UNLABELLED:The P300 component of the event-related potential (ERP) is a general measurement of "cognitive efficiency". It is an index of the ability of an individual's central nervous system (CNS) to process incoming information. OBJECTIVE:To compare the neuromodulatory effects of caffeine and bromazepam on the visual...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,随机对照试验


    authors: Montenegro M,Veiga H,Deslandes A,Cagy M,McDowell K,Pompeu F,Piedade R,Ribeiro P

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: De Mattos JP,Rosso AL,Corrêa RB,Novis S

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


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  • [Guidelines for recording/analyzing quantitative EEG and evoked potentials. Part II: Clinical aspects].

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    journal_title:Arquivos de neuro-psiquiatria

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    authors: Luccas FJ,Anghinah R,Braga NI,Fonseca LC,Frochtengarten ML,Jorge MS,Kanda PA

    更新日期:1999-03-01 00:00:00

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


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    更新日期:1988-03-01 00:00:00

  • Non-paraneoplastic Lambert-Eaton myasthenic syndrome: a brief review of 10 cases.

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    pub_type: 杂志文章


    authors: Lorenzoni PJ,Scola RH,Kay CS,Parolin SF,Werneck LC

    更新日期:2010-12-01 00:00:00

  • Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease.

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Longo GS,Pinhel MS,Sado CL,Gregório ML,Amorim GS,Florim GS,Mazeti CM,Martins DP,Oliveira FN,Tognola WA,Nakazone MA,Souza DR

    更新日期:2013-07-01 00:00:00

  • [Diagnosis and treatment of the most frequent vestibular syndromes].

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Kanashiro AM,Pereira CB,Melo AC,Scaff M

    更新日期:2005-03-01 00:00:00

  • Inattention, hyperactivity, oppositional-defiant symptoms and school failure.

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Serra-Pinheiro MA,Mattos P,Regalla MA,de Souza I,Paixão C

    更新日期:2008-12-01 00:00:00

  • Is there correlation between cognition and functionality in severe dementia? the value of a performance-based ecological assessment for Alzheimer's disease.

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Wajman JR,Oliveira FF,Marin SM,Schultz RR,Bertolucci PH

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    pub_type: 杂志文章


    authors: De Freitas GR,De Oliveira CP,Reis RS,Sarmento MR,Gaspar NK,Fialho M,Praxedes H

    更新日期:1999-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Silberman CD,Laks J,Capitão CF,Rodrigues CS,Moreira I,Engelhardt E

    更新日期:2006-06-01 00:00:00

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    更新日期:1988-03-01 00:00:00

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


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  • Cognitive function assessment in idiopathic Parkinson's disease.

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  • [Prognostic factors related to gunshot wounds to the spine in patients submitted to laminectomy].

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


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  • Oral lysine clonixinate in the acute treatment of migraine: a double-blind placebo-controlled study.

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  • [Medulloblastoma in adults: analysis of a casuistics and surgical results].

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Aguiar PH,Prudente M,Freitas AB,Rotta JM,Plese JP,Andrioli MS

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  • [Carotid endarterectomy under regional anesthesia: follow-up of 104 patients].

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


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  • Rescue therapy with stent retrievers for thromboembolism during endovascular treatment of intracranial aneurysms.

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


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  • [Anatomo-pathological and ultrastructural features of mucopolysaccharidosis. Case report].

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    pub_type: 杂志文章


    authors: Torres LF,De Noronha L,Jacob GV,Antoniuk S

    更新日期:1997-03-01 00:00:00

  • [Precipitating factors of migraine attacks in patients with migraine without aura].

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Ierusalimschy R,Moreira Filho PF

    更新日期:2002-09-01 00:00:00

  • [Trigeminal radiofrequency rhizotomy for the treatment of trigeminal neuralgia: results and technical modification].

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    pub_type: 杂志文章


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    更新日期:2003-06-01 00:00:00

  • [Clinical manifestations in complex partial crisis of the temporal lobe: a video-electroencephalographic study].

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    pub_type: 杂志文章


    authors: Yacubian EM,Valério RM,Jorge CL,Fiore LA,Cukiert A,de Assis LM

    更新日期:1994-06-01 00:00:00