Imipramine for vestibular dysfunction in panic disorder: a prospective case series.

Abstract:

OBJECTIVE:The purpose of this study was to evaluate the efficacy and effectiveness of imipramine on the treatment of comorbid chronic dizziness and panic disorder. METHOD:Nine patients with panic disorder and agoraphobia associated with chronic dizziness underwent otoneurological screening and were treated with a 3-months course of imipramine. Anxiety levels were measured with the Hamilton Anxiety Scale (HAM-A), dizziness levels were evaluated using the Dizziness Handicap Inventory (DHI), and panic severity and treatment outcome were assessed with the Clinical Global Impression Scale (CGI). RESULTS:At the baseline 33.3% (n=3) had a bilateral peripheral deficit vestibulopathy, the mean scores for HAM-A were 27.2±10.4, for DHI were 51.7±22.7, and for CGI-S were 4.8±0.9. All patients had a significant reduction in their HAM-A (11.1±5.5, p=0.008), DHI (11.5±8.1, p=0.008) and CGI-I (1.8±0.7, p=0.011) levels after 3-months imipramine treatment (mean=72.2±23.2 mg/day). CONCLUSION:This study found a decrease in anxiety levels and in the impact of dizziness in the patients' quality of life after a 3-months treatment course with imipramine.

journal_name

Arq Neuropsiquiatr

authors

Mezzasalma MA,Mathias Kde V,Nascimento I,Valença AM,Nardi AE

doi

10.1590/s0004-282x2011000200011

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

196-201

issue

2A

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2011000200011

journal_volume

69

pub_type

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