Abstract:
UNLABELLED:West syndrome (WS) is a severe epileptic encephalopathy of childhood, characterized by spasms, developmental deterioration and hipsarhythymia. OBJECTIVE:To evaluate the safety and efficacy of vigabatrin (VGB) in the treatment of WS. METHOD:We evaluated every patient diagnosed with WS seen at the pediatric epilepsy clinic and exposed to VGB. Patients were interviewed according to a semistructured questionnaire and we analyzed gender, age, etiology (cryptogenic or symptomatic), associated diseases, age of seizure onset, neuroimaging findings, EEG prior and after VGB, use of other antiepileptic drugs, time for seizure control, electroretinogram, visual complaints, adverse events and family history of epilepsy. RESULTS:Twenty-three patients were evaluated, 16 boys, ages ranging from 1.25 years to 11.5 years (mean=5y3m). Sixteen (69.5%) patients were seizure free, five (22%) had partial seizure control and in two (8.5%) there was no improvement. Only one patient presented gabaergic retinopathy. Six (26%) patients presented adverse events: somnolence, aggressivity or retinopathy. Patients with seizure onset after 6 months of age presented better results after VGB introduction (p<0.05). There was no difference in seizure control according to duration of epilepsy before VGB treatment or etiology of the seizures (p>0.05). After VGB, no patient presented hipsarrhythymia and 50% had a normal EEG. CONCLUSION:Although VGB may be associated with serious adverse events such as gabaergic retinopathy, our results show that it should be considered in the treatment of WS.
journal_name
Arq Neuropsiquiatrjournal_title
Arquivos de neuro-psiquiatriaauthors
Moraes MH,Montenegro MA,Franzon RC,Avila JO,Guerreiro MMdoi
10.1590/s0004-282x2005000300019subject
Has Abstractpub_date
2005-06-01 00:00:00pages
469-73issue
2Beissn
0004-282Xissn
1678-4227pii
S0004-282X2005000300019journal_volume
63pub_type
杂志文章abstract::Therapeutic plasmapheresis (plasma exchange) in neurology is a matter of discussion. We review the main articles on clinical trials, both controlled and uncontrolled, trying to establish the efficacy and safety of the procedure. Humoral aspects involved in the genesis of the disorder play an important role for its ind...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1992000300011
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abstract::We report a case of sarcoidosis in a 21 years old male with history of headache since he was three years old, with absence of abnormalities in a brain computerized tomography (CT). Brain magnetic resonance (MRI) disclosed a meningeal involvement with intense and homogeneous enhancement of the right fronto-temporal con...
journal_title:Arquivos de neuro-psiquiatria
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abstract:PURPOSE:We preliminarily investigated the relevance of performing digital subtraction angiography (DSA) in addition to magnetic resonance angiography (MRA) in definition of ischemic stroke etiology in young patients. METHOD:DSAs and MRAs from 17 young patients with nonlacunar ischemic stroke were blindly analyzed and ...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2006000300001
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abstract:UNLABELLED:Adolescence is a period in which youngsters have to make choices such as applying for university. The selection process is competitive, and it brings distress and anxiety, risk factors for the appearance of sleep disorders. OBJECTIVE:To verify the occurrence of sleep disorders in third-year high school and ...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
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abstract:UNLABELLED:The anatomical characterization of the orbitofrontal cortex in human is limited in literature instead of many functional and clinical studies involving it. OBJECTIVE:Anatomically define the orbitofrontal region aiming to possible neurosurgical treatments and unify the scientific nomenclature as well. METHO...
journal_title:Arquivos de neuro-psiquiatria
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abstract::The use of anticoagulants and antiplatelet agents has largely increased. Diagnostic lumbar puncture in patients taking these drugs represents a challenge considering the opposing risks of bleeding and thrombotic complications. To date there are no controlled trials, specific guidelines, nor clear recommendations in th...
journal_title:Arquivos de neuro-psiquiatria
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abstract:UNLABELLED:Studies which have investigated muscular performance during the initial stages of Parkinson's disease (PD) without L-dopa treatments were not found. OBJECTIVE:to assess whether muscular performance, work and power, of the trunk and lower limbs in L-dopa naïve patients in the early stages of PD was lower tha...
journal_title:Arquivos de neuro-psiquiatria
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abstract::Isolated and painless infraspinatus atrophy and weakness are described in two top-level volleyball players. EMG revealed isolated denervation of the infraspinatus muscle. One athlete continued playing and his clinical features have not changed. The other recovered her muscle bulk and strength after stopping playing. T...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1993000100020
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVE:To characterize neurological involvement in juvenile systemic lupus erythe-matosus. METHOD:The charts of all patients with the diagnosis of systemic lupus erythematosus before the age of 16 years, followed at the Rheumatology Unit of Pequeno Príncipe Hospital, from January 1992 to January 2006, were retrospe...
journal_title:Arquivos de neuro-psiquiatria
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doi:10.1590/s0004-282x2007000300013
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abstract:OBJECTIVE:To verify differences in the visual scanning strategies between pervasive developmental disorders (PDD) and controls when they are observing social and non-social pictures. METHOD:PDD group (PDDG) comprised by 10 non-retarded subjects (age from 4 to 41) and age-matched control group (CG). Nine social picture...
journal_title:Arquivos de neuro-psiquiatria
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doi:10.1590/s0004-282x2006000400003
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abstract::We present our experience with 36 cases of nonfunctional pituitary adenomas. These tumors were divided into non reactive and inactive in agreement with the immunohistochemical study. They present with visual symptoms, mainly bitemporal hemianopsia; they were macroadenomas, either invasive or non invasive, in both grou...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2002000100021
更新日期:2002-03-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1997000300013
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of anti-xerostomic topical medication (urea 10%) in patients with burning mouth syndrome (BMS). METHOD:Thirty-eight subjects diagnosed with BMS according to the International Association for the Study of Pain guidelines were randomized to either placebo (5% sodium carboxymethylcellulos...
journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章,随机对照试验
doi:10.1590/0004-282X20130218
更新日期:2014-02-01 00:00:00
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doi:10.1590/s0004-282x2007000700031
更新日期:2007-12-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
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journal_title:Arquivos de neuro-psiquiatria
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doi:10.1590/s0004-282x1994000300022
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journal_title:Arquivos de neuro-psiquiatria
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doi:
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journal_title:Arquivos de neuro-psiquiatria
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doi:10.1590/s0004-282x2006000400023
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2005000600028
更新日期:2005-12-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2005000600018
更新日期:2005-12-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1977000400008
更新日期:1977-12-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2007000600013
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 临床试验,杂志文章
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x2005000600008
更新日期:2005-12-01 00:00:00
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
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journal_title:Arquivos de neuro-psiquiatria
pub_type: 杂志文章
doi:10.1590/s0004-282x1980000200007
更新日期:1980-06-01 00:00:00