[Neuropathy caused by amiodarone: clinico-pathologic study of 2 cases].

Abstract:

:Two patients, a 40-year-old woman and a 75-year-old man, were investigated due to a chronic polyneuritis. Amiodarone was used by them to treat refractory cardiac arrhythmia since 4 and 6 years before, respectively. The EMG study showed an axonal neuropathy. The light and electron-microscopical study of sural nerve displayed a loss of large myelinated fibers and a marked reduction of unmyelinated axons, associated with osmiophilic lamellated inclusions in Schwann cells and endothelial venulae. The interruption of amiodarone therapy improved neuropathy. Considered together with similar reports in perhexiline neuropathy and with chloroquine induced neuropathy this would stress the importance of these new drug-induced neurolipidosis.

journal_name

Arq Neuropsiquiatr

authors

Maciel Júnior JA,Queiroz L

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

474-8

issue

4

eissn

0004-282X

issn

1678-4227

journal_volume

47

pub_type

杂志文章
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    更新日期:1990-12-01 00:00:00

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    更新日期:1991-06-01 00:00:00

  • Clinical and epidemiological profile of patients diagnosed with multiple sclerosis in João Pessoa, Paraíba, Brazil.

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    更新日期:2020-07-01 00:00:00

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  • [EEG alpha band coherence analysis in healthy adults: preliminary results].

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    journal_title:Arquivos de neuro-psiquiatria

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    更新日期:2005-03-01 00:00:00

  • [West syndrome: clinical and electroencephalographic follow up of 70 patients and response to its treatment with adrenocorticotropic hormone, prednisone, vigabatrin, nitrazepam and valproate].

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  • Stroke mortality in São Paulo (1997-2003): a description using the Tenth Revision of the International Classification of Diseases.

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  • [Saphenous vein graft bypass from the external carotid artery to the supraclinoid internal carotid artery to treat a giant aneurysm of the cavernous internal carotid: case report].

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