Depression in patients with refractory temporal lobe epilepsy.

Abstract:

OBJECTIVE:To evaluate the comorbidity of depressive disorders in patients with refractory temporal lobe epilepsy (TLE). METHOD:We evaluated 25 consecutive patients with refractory TLE (16 women and 9 men), using semi-structured psychiatric interviews, according to the International Classification of Diseases (ICD-10), and the Beck Depression Inventory. RESULTS:Seventeen of 25 patients (68%) had depressive disorder: 6 with dysthymia, three with major depressive episodes and 8 with recurrent depressive disorders. Two (8%) were diagnosed with mixed anxiety and depression. Only 5 of 17 patients (29.4%) were previously diagnosed with depressive disorder and received prior antidepressant treatment. Duration of epilepsy was significantly higher in patients with depressive disorder (p=0.016), but there was no relationship between depression and seizure frequency. CONCLUSION:This study confirmed that depressive disorders are common and underdiagnosed in patients with TLE refractory to AEDs. Patients with longer duration of epilepsy are at higher risk of having depression.

journal_name

Arq Neuropsiquiatr

authors

Gonçalves EB,Cendes F

doi

10.1590/s0004-282x2011000600010

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

775-7

issue

5

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2011000600010

journal_volume

69

pub_type

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