Nullity of GSTT1/GSTM1 related to pesticides is associated with Parkinson's disease.

Abstract:

:Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variants were analyzed by polymerase chain reaction. We applied the Fisher's exact test and the χ2 test for statistical analysis (p<0.05). The present and absence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1 and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared to controls (13%, p=0.014). This study suggests the association between PD and previous exposure to pesticides, whose effect may be enhanced in combination with null for GSTT1/GSTM1.

journal_name

Arq Neuropsiquiatr

authors

Pinhel MA,Sado CL,Longo Gdos S,Gregório ML,Amorim GS,Florim GM,Mazeti CM,Martins DP,Oliveira Fde N,Nakazone MA,Tognola WA,Souza DR

doi

10.1590/0004-282X20130076

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

527-32

issue

8

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2013000800527

journal_volume

71

pub_type

杂志文章
  • What's in a name? Problems, facts and controversies regarding neurological eponyms.

    abstract::The use of eponyms in neurology remains controversial, and important questions have been raised about their appropriateness. Different approaches have been taken, with some eponyms being excluded, others replaced, and new ones being created. An example is Hallervorden-Spatz syndrome, which has been replaced by neurode...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 历史文章,杂志文章,评审

    doi:10.1590/0004-282X20160040

    authors: Teive HA,Lima PM,Germiniani FM,Munhoz RP

    更新日期:2016-05-01 00:00:00

  • Margaret Dix, Charles Hallpike and the 'Lagerungs' Manoeuvre.

    abstract::The main objective of this manuscript is to describe some personal and professional aspects of two outstanding researchers and pioneers in neuro-otology. Among other achievements, Margaret Ruth Dix, and Charles Skinner Hallpike, designed the most-used provocative test for positional nystagmus for the diagnosis of lith...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 传,历史文章,杂志文章

    doi:10.1590/0004-282X20180075

    authors: Maranhão-Filho P,Nandi R,Maranhão ET

    更新日期:2018-08-01 00:00:00

  • Ecological validity of the five digit test and the oral trails test.

    abstract::Tests evaluating the attentional-executive system are widely used in clinical practice. However, proximity of an objective cognitive test with real-world situations (ecological validity) is not frequently investigated. The present study evaluate the association between measures of the Five Digit Test (FDT) and the Ora...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/0004-282X20150184

    authors: Paiva GC,Fialho MB,Costa Dde S,Paula JJ

    更新日期:2016-01-01 00:00:00

  • [Viral meningoencephalitis and Klüver-Bucy syndrome. Report of 2 cases].

    abstract::Two cases of partial Klüver-Bucy syndrome developed after probable herpes simplex meningoencephalitis are reported. Clinical, pathological, diagnostic and therapeutic aspects of herpes simplex encephalitis and Klüver-Bucy syndrome are discussed. ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x1986000400008

    authors: Montanha EV,Coral LC

    更新日期:1986-12-01 00:00:00

  • Malignant transformation of pleomorphic xanthoastrocytoma: case report.

    abstract::We report a case of a pleomorphic xantoastrocytoma which manifested itself as a cystic isodense lesion in the right fronto-temporal lobe in a 26 year-old woman. It appeared as a soft yellow tumor with cystic cavities on surgery. Five months after this surgery, the patient was submitted to a new operation, which reveal...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2003000100020

    authors: de Tella OI Jr,Herculano MA,Prandini MN,Stavale JN,Aguiar PH

    更新日期:2003-03-01 00:00:00

  • Quantification of cerebrospinal fluid ferritin as a biomarker for CNS malignant infiltration.

    abstract::Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diag...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2008000500022

    authors: Almeida SM,Cunha DS,Yamada E,Doi EM,Ono M

    更新日期:2008-09-01 00:00:00

  • Light and dark cells in the lumbar sensory ganglia of pre and post-hatching domestic fowl.

    abstract::Clear and dark satellite cell classes were identified by electron microscopy in the lumbar sensory ganglia of domestic fowl in 8 pre and 4 post-hatching stages of development. Some cytologic differences found between the two classes relating to the rough-endoplasmic reticulum, ribosomes, Golgi apparatus and junctional...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x1988000100002

    authors: de Carvalho CA,da Silva CF

    更新日期:1988-03-01 00:00:00

  • Can personality traits, obesity, depression, anxiety, and quality of life explain the association between migraine and disordered eating attitudes?

    abstract:BACKGROUND:Few studies have explored the coexistence of migraine and disordered eating attitudes. Furthermore, the underlying pathophysiological mechanisms of migraine and disordered eating attitude comorbidity are not clearly understood. OBJECTIVE:This study aimed to investigate the association between migraine and d...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/0004-282x20200046

    authors: Hamamci M,Karasalan Ö,İnan LE

    更新日期:2020-09-01 00:00:00

  • Growth status, behavior and neuropsychological performance: a study of Brazilian school age children.

    abstract:AIM:To assess the association between child growth and teacher-reported behavior and academic standing, and neuropsychological performance. METHOD:The heights of 344 public-school children were measured using standard procedures. Teachers were requested to complete two behavioral and one academic performance rating sc...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2004000600004

    authors: Brito GN,Onis Md

    更新日期:2004-12-01 00:00:00

  • Menstrual cycle worsening of epileptic seizures in women with symptomatic focal epilepsy.

    abstract:INTRODUCTION:Hormonal fluctuation is responsible for worsening of epileptic seizures during the menstrual cycle. OBJECTIVE:To identify irregularities in the menstrual cycles of women with mesial temporal lobe epilepsy (MTLE) and extratemporal focal epilepsy (ETFE) and correlate the frequency of seizures during the men...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2005000500006

    authors: Bazán AC,Montenegro MA,Cendes F,Min LL,Guerreiro CA

    更新日期:2005-09-01 00:00:00

  • [Saphenous vein graft bypass from the external carotid artery to the supraclinoid internal carotid artery to treat a giant aneurysm of the cavernous internal carotid: case report].

    abstract::Alternative surgical procedures to treat unclippable aneurysms of the intracavernous carotid artery include proximal vessel occlusion and trapping. Those techniques, even in patients with rich collateral vessels, are associated with risk of hemodynamic compromise and ischemic complications. Therefore, a safe treatment...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2001000100030

    authors: Azevedo Filho H,Martins C,Carvalho A,Geraldo S,Grassi G,Cardoso C,Vilaça G,Rodrigues C

    更新日期:2001-03-01 00:00:00

  • Meningeal carcinomatosis in solid tumors.

    abstract::The involvement of the leptomeninges by metastatic tumors can be observed in solid tumors, in which case it is termed meningeal carcinomatosis (MC), and in lymphoproliferative malignant disease. It is more common in breast and lung cancer, as well as melanoma, with adenocarcinoma being the most frequent histological t...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审

    doi:10.1590/s0004-282x2011000700024

    authors: Martins SJ,Azevedo CR,Chinen LT,Cruz MR,Peterlevitz MA,Gimenes DL

    更新日期:2011-12-01 00:00:00

  • Wrist immobilization after carpal tunnel release: a prospective study.

    abstract::This prospective study evaluates the possible advantages of wrist immobilization after open carpal tunnel release comparing the results of two weeks immobilization and no immobilization. Fifty two patients with idiopathic carpal tunnel syndrome were randomly selected in two groups after open carpal tunnel release. In ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,随机对照试验

    doi:10.1590/s0004-282x2006000400013

    authors: Martins RS,Siqueira MG,Simplício H

    更新日期:2006-09-01 00:00:00

  • Clinical assessment of patients with primary and postparalytic hemifacial spasm: a retrospective study.

    abstract:OBJECTIVE:To compared the clinical features of 373 patients with primary and postparalytic hemifacial spasm (HFS). METHOD:Data analyzed were gender, ethnicity, age at symptom onset, disease duration, affected side, distribution of facial spasm at onset, hypertension, family history of HFS, previous history of facial p...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2007000500009

    authors: Felicio AC,Godeiro-Junior Cde O,Borges V,Silva SM,Ferraz HB

    更新日期:2007-09-01 00:00:00

  • Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease.

    abstract:OBJECTIVE:This study aimed to analyze the frequency of GSTP1-Alw26I polymorphism and to estimate its association with toxic substances in Parkinson's disease (PD). METHODS:A study group with 154 patients - subdivided into familial and sporadic PD groups - and 158 elderly individuals without the disease (control group)...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/0004-282X20130060

    authors: Longo GS,Pinhel MS,Sado CL,Gregório ML,Amorim GS,Florim GS,Mazeti CM,Martins DP,Oliveira FN,Tognola WA,Nakazone MA,Souza DR

    更新日期:2013-07-01 00:00:00

  • [Primary orthostatic tremor: report of 4 cases].

    abstract::We report on four cases of primary orthostatic tremor. The purpose of this study is the rarity of this type of tremor and the differential diagnosis with other tremors. The electrophysiological study showed a 15-20 Hz tremor frequency in our cases. There are clinical, electrophysiological and therapeutic differences o...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2000000100022

    authors: Cavallazzi LO,Machado SN,Matosinho P,Pio FJ

    更新日期:2000-03-01 00:00:00

  • Traumatic subdural hygroma: five cases with changed density and spontaneous resolution.

    abstract::Thirty-four consecutive adult patients with subdural traumatic hygroma were analysed for clinical evolution, serial computed tomography scan (CT), and magnetic resonance imaging (MRI) over a period of several months. Five of the patients presented CT scan and MRI evolution data showing increasing density over a period...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2007000100015

    authors: Zanini MA,Resende LA,Freitas CC,Yamashita S

    更新日期:2007-03-01 00:00:00

  • Correlation of sleep macrostructure parameters and idiopathic epilepsies.

    abstract::Sleep and epilepsy share some common mechanisms. The objective of the present investigation was to study the macrostructure of sleep in patients with idiopathic epilepsies, focal and generalized, comparing these two groups to each other and to a control group of 12 individuals without epilepsy. A total of 35 polysomno...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2002000300002

    authors: Barreto JR,Fernandes RM,Sakamoto AC

    更新日期:2002-06-01 00:00:00

  • When your child with epilepsy dies suddenly: febrile seizures are part of the process?

    abstract::Febrile seizures (FS) affect almost 2-5% of children and factors related to an increase susceptibility of children to FS may involve an imbalance of inflammatory cytokines and genetic factors. FS had low morbidity, but may be associated with the occurrence of late chronic epilepsy. Here we describe factors related to ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审

    doi:10.1590/s0004-282x2011000300022

    authors: Terra VC,Machado HR,Sakamoto AC,Arida RM,Scorza FA

    更新日期:2011-01-01 00:00:00

  • [Lipoma of the corpus callosum with extracranial extension through frontal bone defect].

    abstract::Intracranial lipoma are usually localized in the corpus callosum and rarely extends to the subgaleal region. Only eight cases of lipoma of the corpus callosum with extracranial extension were reported in the literature. Seizures and mental retardation were the most common clinical findings in these patients. Data from...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:

    authors: Martins RS,Ciquini Júnior O,Matushita H,Plese JP

    更新日期:1995-09-01 00:00:00

  • Oral lysine clonixinate in the acute treatment of migraine: a double-blind placebo-controlled study.

    abstract::Several oral nonsteroidal anti-inflammatory drugs (NSAIDs) are effective to treat migraine attacks. Lysine clonixinate (LC) is a NSAID derived from nicotinic acid that has proven to be effective in various pain syndromes such as renal colic and muscular pain. The aim of this double-blind, placebo-controlled study was ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1590/s0004-282x2001000100010

    authors: Krymchantowski AV,Barbosa JS,Cheim C,Alves LA

    更新日期:2001-03-01 00:00:00

  • Post-poliomyelitis syndrome: case report.

    abstract::The post-polio syndrome (PPS) is an entity characterized for an episode of muscular weakness and/or abnormal muscular fatigue in individuals that had presented acute polio years before. We report the case of PPS in a patient, 40 years, that thirty-five years after had had paralytic poliomyelitis, developed new symptom...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2007000300033

    authors: Neves MA,Mello MP,Santos VV,Nascimento OJ,Antonioli Rde S,Freitas GR,Freitas MR

    更新日期:2007-06-01 00:00:00

  • Rosalie: the Brazilian female monkey of Charcot.

    abstract::Jean-Martin Charcot, the father of Neurology, a very austere and reserved man that did not express affection freely for human being, had a profound affection to animals, particularly to a small female monkey, called "Rosalie", which came from Brazil and was a gift of Dom Pedro II to Charcot. ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 传,历史文章,杂志文章

    doi:10.1590/s0004-282x2005000400031

    authors: Teive HA,Arruda WO,Werneck LC

    更新日期:2005-09-01 00:00:00

  • [Peripheral neurological changes in chronic Chagas' disease].

    abstract::The authors review the literature about the cronic nervous form of Chagas' disease, directing their attention toward peripheral neurological aspects. Specifically, they analyse the results obtained from a "bind" research realized in a small community in the countryside of the state of Bahia, Brazil, where a high frequ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x1980000100006

    authors: Fortes-Rêgo J,Macedo VO,Prata A

    更新日期:1980-03-01 00:00:00

  • [Association of neuromotor retardation and chromosome lqH report of a case].

    abstract::A case of neuromotor retardation in association with chromosome 1qh's reported. Chromosomes analysis of the patient and three relatives showed increased long arm on the n. degrees 1 chromosome, in all of them. However it is wmphasized that the clinical feautre could be secondary to various non genetics factors, also. ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:

    authors: Jorge SM,Ribeiro VM,Ferrari I,Moreira LM

    更新日期:1976-12-01 00:00:00

  • The intercostobrachial nerve as a sensory donor for hand reinnervation in brachial plexus reconstruction is a feasible technique and may be useful for restoring sensation.

    abstract:Objective:Few donors are available for restoration of sensibility in patients with complete brachial plexus injuries. The objective of our study was to evaluate the anatomical feasibility of using the intercostobrachial nerve (ICBN) as an axon donor to the lateral cord contribution to the median nerve (LCMN). Methods:...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/0004-282X20170073

    authors: Foroni L,Siqueira MG,Martins RS,Oliveira GP

    更新日期:2017-07-01 00:00:00

  • [Smell recognition in pervasive developmental disorders].

    abstract:AIM:To evaluate smell recognition in pervasive developmental disorders (PDD). METHOD:Twenty-one PDD (experimental group) and 21 matched controls (control group) male adolescents were submitted to a standardized, 12-stimuli, smell battery in three moments: with no identification suggestion; associated to four linguisti...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2007000700021

    authors: Assumpção FB Jr,Adamo S

    更新日期:2007-12-01 00:00:00

  • [Involvement of the central nervous system in cysticercosis].

    abstract::The involvement of the central nervous system in cysticercosis was demonstrate as an incidental finding in a frequence of 0,3% in 4000 autopsied cases. Most of the 12 patients came from rural areas of the State of Bahia. The low frequence compared to other sites reported in Brasil shows that the neurcysticercosis does...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x1979000100005

    authors: De Queiroz AC,Martinez AM

    更新日期:1979-03-01 00:00:00

  • Neuronosology: historical remarks.

    abstract::Classifications for neurological disorders have evolved from following the theory of the humors to modern anatomical pathology and, recently, to the germ theory that stared the etiological era, as seen in book content lists. The symptomatic approach towards neuronosology was widely used until the middle of the 19(th) ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 历史文章,杂志文章

    doi:10.1590/s0004-282x2011000400028

    authors: Gomes Mda M

    更新日期:2011-06-01 00:00:00

  • [Percutaneous vertebroplasty: option of treatment for osteoporotic vertebral fracture].

    abstract::Percutaneous vertebroplasty (PV) is a minimally invasive procedure used to treat focal pain from compressive vertebral fracture. The PV is indicated for the treatment of debilitating vertebral pain from osteoporotic vertebral fractures, metastatic disease (osteolytic), myeloma and hemagioma. We analyzed the results of...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x2003000400019

    authors: Figueiredo N,Amaral Filho JC,Serra Ada R,Nogueira AM,Garcia VC,Weissheimer FL

    更新日期:2003-09-01 00:00:00