Meningeal carcinomatosis in solid tumors.

Abstract:

:The involvement of the leptomeninges by metastatic tumors can be observed in solid tumors, in which case it is termed meningeal carcinomatosis (MC), and in lymphoproliferative malignant disease. It is more common in breast and lung cancer, as well as melanoma, with adenocarcinoma being the most frequent histological type. MC is usually a late event, with disseminated and progressive disease already present and, it is characterized by multifocal neurological signs and symptoms. Diagnosis is based on the evaluation of clinical presentation, cerebrospinal fluid and neuroimaging studies. The better systemic disease control is observed with new therapeutic agents, and the development of neuroimaging methods is responsible for the increasing incidence of such metastatic evolution. Intrathecal chemotherapy is generally the treatment of choice, although frequently palliative. Prognosis is guarded, although a higher performance status may indicate a subgroup of patients with a more favorable outcome.

journal_name

Arq Neuropsiquiatr

authors

Martins SJ,Azevedo CR,Chinen LT,Cruz MR,Peterlevitz MA,Gimenes DL

doi

10.1590/s0004-282x2011000700024

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

973-80

issue

6

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2011000700024

journal_volume

69

pub_type

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