Iatrogenic Creutzfeldt-Jakob disease following human growth hormone therapy: case report.

Abstract:

:We report the case of a 41-year-old man with iatrogenic Creutzfeldt-Jakob disease (CJD) acquired after the use of growth hormone (GH) obtained from a number of pituitary glands sourced from autopsy material. The incubation period of the disease (from the midpoint of treatment to the onset of clinical symptoms) was rather long (28 years). Besides the remarkable cerebellar and mental signs, the patient exhibited sleep disturbance (excessive somnolence) from the onset of the symptoms, with striking alteration of the sleep architecture documented by polysomnography. 14-3-3 protein was detected in the CSF, and MRI revealed increased signal intensity bilaterally in the striatum, being most evident in diffusion-weighted (DW-MRI) sequences. This is the second case of iatrogenic CJD associated with the use of GH reported in Brazil.

journal_name

Arq Neuropsiquiatr

authors

Caboclo LO,Huang N,Lepski GA,Livramento JA,Buchpiguel CA,Porto CS,Nitrini R

doi

10.1590/s0004-282x2002000300022

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

458-61

issue

2-B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2002000300022

journal_volume

60

pub_type

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