Benign multiple sclerosis: aspects of cognition and neuroimaging.

Abstract:

:The existence of a benign multiple sclerosis (BMS) form is a controversial subject. Recent studies of these patients reveal different levels of cognitive impairment, despite the apparent preservation of motor function. The objective of this study was to review and analyze a number of publications that discuss the general aspects of this disease form, such as the definition criteria, prevalence, and clinical and neuroimaging markers. A systematic review of published data on BMS up to October 2015 was performed. Thirty-one published articles were analyzed. The estimated frequency of BMS varied between 6% and 73%. Cognitive impairment was recognized as affecting 17% to 47% of the subjects and presented significant correlation with neuroimaging, such as brain atrophy, increased lesion volume in T2 magnetic resonance assay, and regional grey matter atrophy. The current criteria overestimated the frequency of BMS and, for that reason, this highlights the importance of validating the diagnostic methods practiced.

journal_name

Arq Neuropsiquiatr

authors

Ton AMM,Vasconcelos CCF,Alvarenga RMP

doi

10.1590/0004-282X20170043

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

394-401

issue

6

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2017000600394

journal_volume

75

pub_type

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