Clinical features and treatment with botulinum toxin in blepharospasm: a 17-year experience.

Abstract:

OBJECTIVE:It was to analyze clinical aspects of patients with blepharospasm, including outcomes of botulinum toxin treatment. Additionally, clinical characteristics of isolated blepharospasm were compared to those of blepharospasm plus other movement disorders. METHODS:Clinical data recorded during 17 years were reviewed. The variables included age, gender, age of onset, past medical history, head trauma, smoking history, family history of dystonia, severity, duration of botulinum toxin relief and adverse effects. RESULTS:A total of 125 patients were included and 75.2% were female. The mean age of onset was 54.3 years; 89.6% of the individuals started with contractions in eye region, and 39.2% of them spread to lower face or neck. Isolated blepharospasm group was compared with blepharospasm-plus group for demographic and clinical features, and therapeutic outcomes, without significant differences. Botulinum toxin treatment improved the severity of contractions (p=0.01) with low rate of side effects (14%). CONCLUSIONS:Both groups - isolated blepharospasm and blepharospasm-plus - shared similar results concerning epidemiology, clinical features and therapeutic response to botulinum toxin.

journal_name

Arq Neuropsiquiatr

authors

Aquino CC,Felício AC,Castro PC,Oliveira RA,Silva SM,Borges V,Ferraz HB

doi

10.1590/s0004-282x2012000900003

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

662-6

issue

9

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2012000900003

journal_volume

70

pub_type

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