Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease.

Abstract:

OBJECTIVE:This study aimed to analyze the frequency of GSTP1-Alw26I polymorphism and to estimate its association with toxic substances in Parkinson's disease (PD). METHODS:A study group with 154 patients - subdivided into familial and sporadic PD groups - and 158 elderly individuals without the disease (control group) were evaluated. GSTP1-Alw26I polymorphism was analyzed by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP). RESULTS:Patients were significantly more exposed to pesticides compared with the control group (p=0.0004), and the heterozygote genotype associated to exposure to pesticides also prevailed in patients (p=0.0001). Wild homozygote genotype was related to tobacco use (p=0.043) and alcoholism (p=0.033) in familial PD patients. CONCLUSION:Exposure to pesticides is associated to PD, whose effect can be enhanced when combined with the heterozygote genotype of GSTP1-Alw26I. Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings.

journal_name

Arq Neuropsiquiatr

authors

Longo GS,Pinhel MS,Sado CL,Gregório ML,Amorim GS,Florim GS,Mazeti CM,Martins DP,Oliveira FN,Tognola WA,Nakazone MA,Souza DR

doi

10.1590/0004-282X20130060

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

446-52

issue

7

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2013000700446

journal_volume

71

pub_type

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