HTLV-1 antibodies in serum and cerebrospinal fluid in tropical spastic paraparesis in Brazil.

Abstract:

:HTLV-1 antibodies were investigated in serum and in CSF of 150 patients with neurologic disorders mainly myelopathies. The patients were considered into three groups according to the possible relationship of their disease to the presence of HTLV-1 antibodies: no relationship risk (control group), occasional risk group, and possible risk group. In this latter are 56 patients with crural spastic paraparesis or paraplegia of unknown etiology (SP). HTLV-1 antibodies were tested by the passive particle-agglutination method for anti-ATLA antibody detection. The search was negative in all patients of the control group, and positive (serum and/or CSF) in 16.5% of the patients from the second group and in 55.4% of the SP patients group. Clinical patterns in SP cases with HTLV-1 antibodies were those of tropical spastic paraparesis (TSP). CSF patterns considered (cytology, protein content and gamma-globulins rate) were different between TSP group with HTLV-1 antibodies in CSF and SP group with no HTLV-1 antibodies detection either in serum or in CSF. The difference was significant. Results of this investigation confirm the high incidence of TSP in Brazil, and bring additional indication for searching HTLV-1 antibodies in the CSF.

journal_name

Arq Neuropsiquiatr

authors

Spina-França A,Livramento JA,Machado LR,Gomes HR,Vianna LS,Castro LH,Nóbrega JP,Bacheschi LA

doi

10.1590/s0004-282x1990000400007

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

441-7

issue

4

eissn

0004-282X

issn

1678-4227

journal_volume

48

pub_type

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