Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate.

Abstract:

OBJECTIVE:Investigate the auditory pathway in the brainstem of children with acute lymphoblastic leukemia submitted to chemotherapy (by intravenous or intrathecal infusion). METHODS:Fourteen children aged between 2 and 12 years with diagnosis of acute lymphoid leukemia were evaluated. The following procedures were used: meatoscopy, acoustic immitance measurements, tonal audiometry, vocal audiometry, transient otoacoustic emissions, and auditory brainstem response. RESULTS:From the 14 children with normal auditory thresholds, 35.71% showed an alteration in auditory brainstem response, with a predominance of hearing impairment in the lower brainstem. It was found that 80% of the children with alteration had used intrathecal methotrexate less than 30 days and that 40% had the highest cumulative intravenous methotrexate doses. CONCLUSION:Children with acute lymphoblastic leukemia submitted to chemotherapy, present auditory pathway impairment in the brainstem, with a predominance of a low brainstem.

journal_name

Arq Neuropsiquiatr

authors

Leite RA,Vosgrau JS,Cortez Neto L,Santos NP,Matas SLA,Odone Filho V,Matas CG

doi

10.1590/0004-282X20190139

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

63-69

issue

2

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2020005003102

journal_volume

78

pub_type

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