Quetiapine for the prevention of migraine refractory to the combination of atenolol + nortriptyline + flunarizine: an open pilot study.


BACKGROUND:Migraine is a prevalent neurological disorder. Although prevention is the mainstream treatment, some patients are refractory to standard therapies. AIM:To evaluate the use of quetiapine (QTP) in the preventive treatment of refractory migraine, defined as previous unresponsiveness to the combination atenolol + nortriptyline + flunarizine. METHOD:Thirty-four consecutive patients (30 women and 4 men) with migraine (ICHD-II) and headache attacks on less than 15 days per month not overusing symptomatic medications were studied. The main inclusion criterion was the lack of response (<50% reduction in attack frequency) after ten weeks to the combination of atenolol (60 mg/day) + nortriptyline (25 mg/day) + flunarizine (3 mg/day). The patients started on QTP as the sole treatment in a single daily dose of 25 mg, titrated to 75 mg. After ten weeks, headache frequency, consumption of rescue medications and adverse events were analyzed. RESULTS:Twenty nine patients completed the study. Among completers, 22 (75.9%; 64.7% of the intention-to-treat population) presented >50% headache reduction. The mean frequency of migraine days decreased from 10.2 to 6.2 and the average consumption of rescue medications decreased from 2.3 to 1.2 days/week. Adverse events were reported by 9 (31%) patients. CONCLUSION:Although limited by the open design, this study provides a pilot data to support the use of quetiapine in preventive treatment of refractory migraine.


Arq Neuropsiquiatr


Krymchantowski AV,Jevoux C




Has Abstract


2008-09-01 00:00:00














  • [Fibrous dysplasia of the skull: neurologic manifestations].

    abstract::The neurological manifestations of eight patients with osseous fibrous dysplasia of skull were retrospectively studied. In this series, the frontal bone was involved in 75% of the patients, the sphenoid or temporal bones in 37.5%, and the parietal in 25%. It was observed that cranial deformities occurred in all but on...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Freitas PE,Ribeiro TR,Coutinho MF,Anicet A

    更新日期:1989-06-01 00:00:00

  • [Charcot-Marie-Tooth disease. Electromyographic studies in 45 patients].

    abstract::The electrophysiological studies of 45 patients with Charcot-Marie-Tooth disease (CMT) are presented. The nerve conduction of the motor median and ulnar nerves permitted us to separate our patients in two types: type I (demyelinating) with motor nerve conduction (MNC) below 38 m/s (11 cases) and type II with MNC norma...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 临床试验,杂志文章


    authors: Freitas MR,Nascimento OJ,Nevares MT,Escada TM

    更新日期:1995-09-01 00:00:00

  • [Expectoration of cerebrospinal fluid: an unusual complication of ventriculoperitoneal shunt].

    abstract::A child, who had undergone ventriculoperitoneal shunting, presented with repeated episodes of pneumonia and expectoration of CSF. Chest x-ray demonstrated the presence of the shunt catheter in the base of the left lung. In the present case the distal end of the catheter perforated the diaphragm, entering the thoracic ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Ferreira NP,Costa DM Jr,Flores JA

    更新日期:1980-12-01 00:00:00

  • Is there something special about cardiovascular abnormalities and sudden unexpected death in epilepsy among patients with chronic renal insufficiency in regular hemodialysis program?

    abstract::Of the many risk factors suggested for sudden unexpected death in epilepsy (SUDEP), higher frequency of seizures is a very consistent issue. Following this reasoning, it has been established that hemodialysis-associated seizure is a complication of dialysis procedure. Based on these facts, this study investigated a po...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Gomes RA,Kesrouani S,Cruz J,Silva AL,Henriques TM,Albuquerque Md,Arida RM,Sonoda EY,Cysneiros RM,Terra VC,Scorza CA,Cavalheiro EA,Scorza FA

    更新日期:2009-06-01 00:00:00

  • Neurosarcoidosis: guidance for the general neurologist.

    abstract::Neurosarcoidosis (NS) more commonly occurs in the setting of systemic disease. The diagnosis is based on a clinical history suggestive of NS, presence of noncaseating granulomas, and supportive evidence of sarcoid pathology, laboratory, and imaging studies. NS could involve any part of the nervous system and often dem...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审


    authors: Dutra LA,Braga-Neto P,Oliveira RA,Pedroso JL,Abrahão A,Barsottini OG

    更新日期:2012-04-01 00:00:00

  • [Electromyographic and neurological aspects of leprosy. Study of 100 cases].

    abstract::By the neurological, electromyographic, anatomopathological and bacterioscopic examinations of 100 pacients with leprosy the following conclusions have been drawn: There was a high incidence of reflex abnormalities. The proprioceptive reflexes were abnormal in 64.5% and the superficial reflexes in 70.8% of the cases. ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Sena PG

    更新日期:1976-03-01 00:00:00

  • Facial sensory symptoms in medullary infarcts.

    abstract:OBJECTIVE:To investigate the correlation between facial sensory abnormalities and lesional topography in eight patients with lateral medullary infarcts (LMIs). METHOD:We reviewed eight sequential cases of LMIs admitted to the Neurology Division of Hospital das Clínicas/São Paulo University between July, 2001 and Augus...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Conforto AB,Yamamoto FI,Leite Cda C,Scaff M,Marie SK

    更新日期:2005-12-01 00:00:00

  • Neuronosology: historical remarks.

    abstract::Classifications for neurological disorders have evolved from following the theory of the humors to modern anatomical pathology and, recently, to the germ theory that stared the etiological era, as seen in book content lists. The symptomatic approach towards neuronosology was widely used until the middle of the 19(th) ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 历史文章,杂志文章


    authors: Gomes Mda M

    更新日期:2011-06-01 00:00:00

  • [Electroencephalogram before and after hemodialysis, peritoneal dialysis and renal transplantation: study of correlations between background activity and plasma biochemistry].

    abstract::We report disorganization of background activity in the EEG of 49 patients with chronic renal failure. An electroencephalographic and biochemical study was performed in 20 patients before and after dialysis sessions. We did the same study before and after peritoneal dialysis in 14 patients. We analysed the EEG compare...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审


    authors: Resende LA,Speciali JG

    更新日期:1987-09-01 00:00:00

  • Endovascular therapy for selected (most non-surgical) intracranial aneurysms in a Brazilian University Hospital.

    abstract:OBJECTIVE:The objective of this study was to evaluate technical, clinical and angiographic results of a nonsurgical series of intracranial aneurysms treated by endovascular approach at Hospital das Clínicas of Medical School of Ribeirão Preto - University of São Paulo. METHOD:Between August 2005 and November 2008, 137...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Abud DG,Nakiri GS,Abud TG,Carlotti CG Jr,Colli BO,Santos AC

    更新日期:2010-10-01 00:00:00

  • [Chronic muscular dysfunction of the bulbar innervation in hyperthyroidism: report of a case].

    abstract::The authors report a case of chronic bulbar muscular dysfunction in a thyrotoxic man, with complete remission of the symptoms after the use of propranolol, with and without concomitant use of propylthiouracil. Some aspects of this unique complication of hyperthyroidism are discussed. ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Cardoso Bde A,Schulz I,Preger A,Arruda WO

    更新日期:1988-12-01 00:00:00

  • [Adequate neuropsychological evaluation of dementia].

    abstract::The authors discuss the protocol of the Optimal Neuropsychological Evaluation of Dementias of Montreal and its possible application in Brazil. This protocol is important for evaluation in neuropsychological evolution of dementia of the Alzheimer type and for bringing to the fore distinct affected cognitive profiles as...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: de Brito-Marques PR,Joanette Y,Poissant A,Ska B

    更新日期:1995-03-01 00:00:00

  • [Russel's syndrome: diencephalic tumor in a child].

    abstract::The case of a male child with Russel's syndrome due to a pilocytic astrocytoma located in the diencephalic region is presented. The diagnosis was made in the 16th month of age, but symptoms began in the 4th months of life, when he started losing weight. By the time he was admitted weight was 6150g and he was 74cm tall...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Da Motta LA,Garcia Filho OV,Horta MP,Lima BO,Pratesi R,Farage Filho M

    更新日期:1990-03-01 00:00:00

  • Autism spectrum disorder and celiac disease: no evidence for a link.

    abstract:OBJECTIVE:To evaluate the possible association between celiac disease (CD) and/or gluten sensitivity (GS) and autism spectrum disorder (ASD). METHODS:Occurrences of CD were determined in a group of children and adolescents affected by ASD and, conversely, occurrences of ASD were assessed in a group of biopsy-proven ce...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Batista IC,Gandolfi L,Nobrega YK,Almeida RC,Almeida LM,Campos Junior D,Pratesi R

    更新日期:2012-01-01 00:00:00

  • Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis.

    abstract::We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Varella PP,Santiago JF,Carrete H Jr,Higa EM,Yacubian EM,Centeno RS,Caboclo LO,Castro Neto EF,Canzian M,Amado D,Cavalheiro EA,Naffah-Mazzacoratti Mda G

    更新日期:2011-02-01 00:00:00

  • Expression of NMDA receptor and microRNA-219 in rats submitted to cerebral ischemia associated with alcoholism.

    abstract:Objective::To evaluate the microRNA-219 and NMDA expression in brain tissue and blood of animals subjected to cerebral ischemia associated with alcoholism. Methods::Fifty Wistar rats were divided into groups: control, sham, ischemic, alcoholic, and ischemic plus alcoholic. The expression of microRNA-219 and NMDA were ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Silva CI,Novais PC,Rodrigues AR,Carvalho CA,Colli BO,Carlotti CG Jr,Tirapelli LF,Tirapelli DP

    更新日期:2017-01-01 00:00:00

  • Inattention, hyperactivity, oppositional-defiant symptoms and school failure.

    abstract:BACKGROUND:Attention-deficit hyperactivity disorder (ADHD) is associated with school failure. Inattention has been mainly implicated for this association. Oppositional-defiant disorder's (ODD) impact on academic performance remains controversial, because of the high comorbidity between ODD and ADHD. OBJECTIVE:To under...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Serra-Pinheiro MA,Mattos P,Regalla MA,de Souza I,Paixão C

    更新日期:2008-12-01 00:00:00

  • [Familial hemifacial spasm: report of 2 cases].

    abstract::The authors report the clinical and angiographical findings of two cases of familial hemifacial spasm. This is the fifth description in the literature and presents mother and daughter at the ages of 76 and 51 respectively, in whom the left side was affected. They underwent exams of angioresonance that showed dolichoba...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Barbosa ER,da Costa Mdo D,Staut CC,Bacheschi LA,Bittar MS

    更新日期:1998-03-01 00:00:00

  • [Psychiatric disorders in patients with diabetes type 2 at medical care and training district of Rio Branco-Acre, Brazil].

    abstract:INTRODUCTION:Studies have established higher prevalence of psychiatric disorders in diabetic patients. OBJECTIVE:To describe the socio-demographic and clinic characteristics and to compare the frequency of them in the diabetic and non-diabetic populations. METHOD:Transversal study with comparing groups. Eighty four d...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Clavijo M,Carvalho JJ,Rios M,de Oliveira IR

    更新日期:2006-09-01 00:00:00

  • Correlation between parameters of electrophysiological, histomorphometric and sciatic functional index evaluations after rat sciatic nerve repair.

    abstract::The rat sciatic nerve is a well-established model for the study of recovery from peripheral nerve injuries. Traditional methods of assessing nerve regeneration after nerve injury and repair, such as electrophysiology and histomorphometry, despite widely used in neural regeneration experiments, do not necessarily corre...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Martins RS,Siqueira MG,da Silva CF,Plese JP

    更新日期:2006-09-01 00:00:00

  • [Precipitating factors of migraine attacks in patients with migraine without aura].

    abstract::To study the distribution of triggers of migraine in a selected population, 100 patients who fulfilled the diagnostic criteria for migraine without aura as proposed by the International Headache Society were evaluated by means of a personal interview. Stress was the most cited trigger, triggering migraine in 76%. Afte...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Ierusalimschy R,Moreira Filho PF

    更新日期:2002-09-01 00:00:00

  • Environmental air pollution is an aggravating event for sudden unexpected death in epilepsy.

    abstract::It is extremely difficult to estimate the occurrence of sudden unexpected death in epilepsy (SUDEP). On the other hand, discovering and carefully evaluating new risk factors that may contribute to the onset of cardiovascular abnormalities in people with refractory epilepsy may prevent fatal events in these individuals...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Scorza CA,Calderazzo L,Arida RM,Cavalheiro EA,Scorza FA

    更新日期:2013-10-01 00:00:00

  • Malignant transformation of pleomorphic xanthoastrocytoma: case report.

    abstract::We report a case of a pleomorphic xantoastrocytoma which manifested itself as a cystic isodense lesion in the right fronto-temporal lobe in a 26 year-old woman. It appeared as a soft yellow tumor with cystic cavities on surgery. Five months after this surgery, the patient was submitted to a new operation, which reveal...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: de Tella OI Jr,Herculano MA,Prandini MN,Stavale JN,Aguiar PH

    更新日期:2003-03-01 00:00:00

  • Professor Octávio de Silveira: the pioneer of neurology in the State of Paraná.

    abstract::The author gives a brief overview of the career of Professor Octávio da Silveira, the first neurologist and professor of neurology in the State of Paraná, as well as the first full professor of clinical neurology in the Federal University of Paraná. ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 传,历史文章,杂志文章


    authors: Teive HA

    更新日期:2008-09-01 00:00:00

  • Aggressive intracranial fibromatosis: case report.

    abstract:UNLABELLED:Fibromatosis is a locally aggressive, proliferative fibroblastic lesion affecting musculoaponeurotic structures, most often in the limbs and trunk. Intracranial fibromatosis is extremely rare and requires aggressive treatment to prevent recurrence. CASE DESCRIPTION:We present the case of a 20 year old woman...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: de Tella OI Jr,Silva LR,Stavale JN,Herculano MA,de Paiva Neto MA,Agner C

    更新日期:2006-06-01 00:00:00

  • Celebrating the 70 years of pyridostigmine on therapy of Myasthenia Gravis: historical aspects of the preliminary trials.

    abstract::Currently, pyridostigmine bromide is an indispensable anticholinesterase agent used worldwide to treat patients with Myasthenia Gravis (MG). However, pyridostigmine bromide was unsuccessful in its "pioneering trials" to treat a series of MG patients. There are important historical landmarks before pyridostigmine bromi...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审


    authors: Lorenzoni PJ,Kay CSK,Ducci RD,Fustes OJH,Werneck LC,Scola RH

    更新日期:2020-03-01 00:00:00

  • Discrepancy, coincidence or evidence in chronic idiopathic spastic paraparesis throughout the world. A meta-analysis on 2811 patients.

    abstract::HTLV-I has been associated with a chronic idiopathic spastic paraparesis (CHISPA) in man; however, a complete understanding of this association is still debated. We selected the most comprehensible papers on this topic between 1985 and 1996, and found that 1261 out of 2811 patients (44.9%) reported, throughout the wor...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Leon-S FE,Costa CM,Gaffga N

    更新日期:1997-09-01 00:00:00

  • Cognitive deficits in chronic pain patients, in a brief screening test, are independent of comorbidities and medication use.

    abstract::Objective To describe and analyze cognitive aspects in patients with chronic pain and a control group without pain. Method A case-control study was conducted on 45 patients with chronic pain and on 45 control subjects. Data including pain diagnosis, comorbidities and medication used, were evaluated. Cognitive tests, s...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Ferreira Kdos S,Oliver GZ,Thomaz DC,Teixeira CT,Foss MP

    更新日期:2016-05-01 00:00:00

  • [West syndrome: apropos of 9 cases].

    abstract::West syndrome is a peculiar form of epilepsy of infancy and childhood characterized by spasms or massive myoclonus, regression neuropsychomotor development, and EEG abnormalities referred as hipsarrhythmia. We report nine cases of West syndrome discussing clinical, etiological, evolutive and therapeutic features. ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Kamiyama MA,Yoshinaga L,Tonholo-Silva ER

    更新日期:1993-09-01 00:00:00

  • Hypersomnia in Whipple disease: case report.

    abstract::Whipple disease (WD) is a rare systemic infection caused by Tropheryma whippelii. Neurological involvement has been recognised in 40% of patients, either as initial manifestations or during the course of the disease. We report on a 45 years-old man with WD with initial, persistent and irresistible episodes of daytime ...

    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章


    authors: Maia LF,Marta M,Lopes V,Rocha N,Lopes C,Martins-da-Silva A,Monteiro L

    更新日期:2006-09-01 00:00:00