[Neuromuscular abnormalities in disuse, ageing and cachexia].

Abstract:

:Cachexia, ageing and disuse and their effects on the human and animals neuromuscular system are reviewed. Disuse induces reduction of muscle fibers (mainly II) diameter with peripheral myofibrils lost; there is no core-targetoid or even reduction on myophosphorilase activity, both typical of denervation; the acetylcholine spontaneous release and trophic factors on myoneural junction are maintained; muscle fibers could change to angular shape. Ageing affects nerve and muscle by a continuous and progressive process of denervation and reinnervation; the number of motor units diminishes in sixties without any denervation electric activity; there is also reduction on the amount of ACh release on terminal neurons and mitochondrial oxidative capacity leading to compensatory type I muscle fiber number increase. Cachexia also induces reduction on muscle fibers diameter first on legs and then on arms and trunk; there is type II atrophy with occasional angular fibers, RNA/proteic synthesis reduction and normal DNA.

journal_name

Arq Neuropsiquiatr

authors

Kouyoumdjian JA

doi

10.1590/s0004-282x1993000300001

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

299-306

issue

3

eissn

0004-282X

issn

1678-4227

journal_volume

51

pub_type

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