Teratogenic effects of lamotrigine on rat fetal brain: a morphometric study.

Abstract:

:A study of the teratogenic activity of an antiepileptic drug - lamotrigine - was carried out in the brain of fetuses of rats who had received the drug. The dosage levels studied corresponded to four times the median effective dose (ED50) in rats. The drug was administered during the organogenesis period. Rats were sacrificed one day prior to term and fetuses were macroscopically examined, weighted and cephalic segments sectioned (Wilson technique), for histological study by stereological analysis, using Merz's grid for drawing and point counts. Cortex, subcortex, ependyma and lateral ventricles were analyzed. The same methodology was applied to the control group; data were compared with by the non-parametric Mann-Whitney statistical analysis test. Results showed that fetuses of the experimental group had reduced body weight at birth, increased volume and diameter of the cerebral structure, increased density of the subcortical layer, and ventricle dilatation. Possible mechanisms of this teratogenicity were discussed.

journal_name

Arq Neuropsiquiatr

authors

Marchi NS,Azoubel R,Tognola WA

doi

10.1590/s0004-282x2001000300010

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

362-4

issue

2-B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2001000300010

journal_volume

59

pub_type

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