[Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300): a comparative study].

Abstract:

UNLABELLED:The P300 component of the event-related potential (ERP) is a general measurement of "cognitive efficiency". It is an index of the ability of an individual's central nervous system (CNS) to process incoming information. OBJECTIVE:To compare the neuromodulatory effects of caffeine and bromazepam on the visual ERP (P300), in relation to a P300 normative database. METHOD:15 right-handed individuals (7 male and 8 female), between 20 and 30 years of age, healthy, free of any cognitive impairment and not making use of psychoactive substances were studied. Participants were submitted to a visual discrimination task, which employed the "oddball" paradigm, after the administration of caffeine and bromazepam, in a randomized, double-blind design. RESULTS:Statistically significant differences were observed when the caffeine and bromazepam conditions were compared to the normative database. CONCLUSION:The present results suggest that caffeine and bromazepam have distinct modulatory effects on CNS functioning.

journal_name

Arq Neuropsiquiatr

authors

Montenegro M,Veiga H,Deslandes A,Cagy M,McDowell K,Pompeu F,Piedade R,Ribeiro P

doi

10.1590/s0004-282x2005000300009

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

410-5

issue

2B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2005000300009

journal_volume

63

pub_type

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