Low specificity and sensitivity of smell identification testing for the diagnosis of Parkinson's disease.

Abstract:

OBJECTIVE:The aim of this study is to determine if the University of Pennsylvania's Smell Identification Test (UPSIT) is an accurate diagnostic tool for olfactory dysfunction in Parkinson's disease (PD). METHOD:We included 138 non-demented PD subjects and 175 control subjects matched by gender. Smell identification was tested using UPSIT. RESULTS:The mean number of UPSIT items correctly identified by controls was 27.52 ± 5.88; the mean score for PD subjects was 19.66 ± 6.08 (p=<0.001). UPSIT sensitivity was 79.7% with a specificity of 68.5% using a cut-off score of ≤ 25. The overall accuracy for the diagnosis of PD was of 75.3%. CONCLUSION:UPSIT accuracy and specificity were lower than what has been previously reported. Our data demonstrates that 17.5% of items of the UPSIT were not well identified by healthy controls. Further research of the identification of a truly cross-cultural test is warranted.

journal_name

Arq Neuropsiquiatr

authors

Rodríguez-Violante M,Gonzalez-Latapi P,Camacho-Ordoñez A,Martínez-Ramírez D,Morales-Briceño H,Cervantes-Arriaga A

doi

10.1590/0004-282X20130190

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

33-7

issue

1

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2014000100033

journal_volume

72

pub_type

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