[Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report].

Abstract:

OBJECTIVE:the aim of this report is to warn that sodium valproate used during pregnancy can produce craniosynostosis in the newborn, particularly trigonocephaly. METHOD:we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy. We also review current literature about this topic. RESULT:bone sclerosis over the metopic suture was confirmed during surgery. Bibliographical review yields previous reports on valproate teratogenicity, mainly determining metopic suture craniosynostosis. CONCLUSION:sodium valproate used during pregnancy can produce craniosynostosis by teratogenic effect, specially trigonocephaly (premature fusion of metopic suture).

journal_name

Arq Neuropsiquiatr

authors

Assencio-Ferreira VJ,Abraham R,Veiga JC,Santos KC

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

417-20

issue

2-B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2001000300020

journal_volume

59

pub_type

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