Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder.

Abstract:

:Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK(®) software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic χ(2) association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the role of the immune system in its pathogenesis.

journal_name

Arq Neuropsiquiatr

authors

Cappi C,Muniz RK,Sampaio AS,Cordeiro Q,Brentani H,Palácios SA,Marques AH,Vallada H,Miguel EC,Guilherme L,Hounie AG

doi

10.1590/s0004-282x2012000200003

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

87-90

issue

2

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2012000200003

journal_volume

70

pub_type

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