Neurodegenerative changes in the brainstem and olfactory bulb in people older than 50 years old: a descriptive study.

Abstract:

:With the increase in life expectancy in Brazil, concerns have grown about the most prevalent diseases in elderly people. Among these diseases are neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Protein deposits related to the development of these diseases can pre-date the symptomatic phases by years. The tau protein is particularly interesting: it might be found in the brainstem and olfactory bulb long before it reaches the limbic cortex, at which point symptoms occur. Of the 14 brains collected in this study, the tau protein was found in the brainstems of 10 (71.42%) and in olfactory bulbs of 3 out 11. Of the 7 individuals who had a final diagnosis of Alzheimer's disease (AD), 6 presented tau deposits in some region of the brainstem. Our data support the idea of the presence of tau protein in the brainstem and olfactory bulb in the earliest stages of AD.

journal_name

Arq Neuropsiquiatr

authors

Oliveira FH,Rodrigues Neto E,Fonseca MK,Costa AS,Rockenbach MA,Padilha Rdos S,Fernandez LL,Hilbig A

doi

10.1590/0004-282X20150066

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

569-77

issue

7

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2015000700569

journal_volume

73

pub_type

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