Benefit with methylprednisolone in continuous pulsetherapy in progressive primary form of multiple sclerosis: study of 11 cases in 11 years.

Abstract:

:Primary progressive multiple sclerosis (PPMS) is defined clinically with a progressive course from onset. There is no approved treatment for the PPMS. Methylprednisolone IV (MP) hastens the recovery from MS relapses. We studied 11 patients that met the MacDonald's diagnostic criteria for PPMS. The dose of MP was 30 mg/kg in 250 mL of glucose solution in three consecutive days during the first week, two doses during the second and one dose in the third week. One weekly session for eight consecutive weeks was given. After, a once-a week/eight-week interval was maintained. The medium EDSS before treatment was 6.2, and after 11.2 years of treatment, the EDSS was 4.9. Although we studied a small sample of PPMS we may conclude that therapy with IVMP prevents clinical worsening of MS in the majority of patients with improvement in EDSS scores.

journal_name

Arq Neuropsiquiatr

authors

Araújo EA,Freitas MR

doi

10.1590/s0004-282x2008000300013

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

350-3

issue

2B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2008000300013

journal_volume

66

pub_type

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