Amyotrophic lateral sclerosis with dementia. Case report.

Abstract:

:A patient is described in whom a profound and rapidly progressive dementia occurred in association with clinical features of amyotrophic lateral sclerosis. A magnetic resonance imaging showed signs of frontal and especially left temporal atrophy. The pattern of dementia indicated impaired frontotemporal lobe functions, evidenced by reduced tracer uptake in the frontotemporal lobes on brain single photon emission computed tomography. Neuropathological examination in this patient revealed mild frontotemporal atrophy with spongiform changes and neuronal loss affecting mainly layers II and III of the frontotemporal cortices. There was atrophy of the hypoglossal nuclei. The spinal cord changes were consistent with motor neuron disease. The patient showed an irreversible and progressive course. A review of the relevant literature was made.

journal_name

Arq Neuropsiquiatr

authors

de Brito-Marques PR,de Mello RV

doi

10.1590/s0004-282x1999000200018

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

277-83

issue

2A

eissn

0004-282X

issn

1678-4227

journal_volume

57

pub_type

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