Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study.

Abstract:

UNLABELLED:Topical treatments have gained popularity for general use as an adjunct to systemic drugs in neuropathic pain, but their use produces variable clinical results and local adverse events. OBJECTIVE:To evaluate the safety and analgesic effect of a formulation of liposomal capsaicin (LC) (0.025%) in patients with post herpetic neuralgia (PHN). METHOD:Patients who remained symptomatic after first-and second-line treatment were randomized to receive LC for six weeks in a placebo-controlled, crossover design study. Clinical assessment was performed at baseline, in the second, fourth and sixth week of treatment. RESULTS:Thirteen patients completed both treatment periods. Visual Analog Scale (VAS) was significantly decreased after the end of the study (p = 0.008), however the effect of treatment was not significant (p = 0.076). There was no difference on global impression of change and other pain characteristics. LC was safe and well tolerated. However, at the concentration used, its analgesic effects were marginal and not significant.

journal_name

Arq Neuropsiquiatr

authors

Teixeira MJ,Menezes LM,Silva V,Galhardoni R,Sasson J,Okada M,Duarte KP,Yeng LT,Andrade DC

doi

10.1590/0004-282X20140232

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

237-40

issue

3

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2015000300237

journal_volume

73

pub_type

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