[West syndrome: clinical and electroencephalographic follow up of 70 patients and response to its treatment with adrenocorticotropic hormone, prednisone, vigabatrin, nitrazepam and valproate].

Abstract:

:In a retrospective study we assessed the outcome of the criptogenic and symptomatic forms of West syndrome and evaluated the efficacy of adrenocorticotropic hormone, vigabatrin, prednisone, valproate and nitrazepam in the spasms control. Seventy patients were follwed up by 2 years. Twelve (17%) were criptogenics and 58 (83%) symptomatics. In criptogenic group significantly more patients were in regular school classes and with normal motor development, better control of seizure, less tendency to evoluate to Lennox Gastaut syndrome and 83. 3% had control of spasms (72.4% of patients from symptomatic group had control of spasms). Adrenocorticotropic hormone and vigabatrin were the most efective drugs, with 68.75% and 60% of spasms control, respectivelly, when used as first line of therapy and 75% and 50%, respectivelly, as second line of therapy.

journal_name

Arq Neuropsiquiatr

authors

Antoniuk SA,Bruck I,Spessatto A,Halick SM,de Bruyn LR,Meister E,de Paola D

doi

10.1590/s0004-282x2000000400014

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

683-90

issue

3A

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2000000400014

journal_volume

58

pub_type

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