Clinical, laboratory and neuroimage findings in juvenile systemic lupus erythematosus presenting involvement of the nervous system.

Abstract:

OBJECTIVE:To characterize neurological involvement in juvenile systemic lupus erythe-matosus. METHOD:The charts of all patients with the diagnosis of systemic lupus erythematosus before the age of 16 years, followed at the Rheumatology Unit of Pequeno Príncipe Hospital, from January 1992 to January 2006, were retrospectively reviewed, highlighting neuropsychiatric aspects. RESULTS:Forty-seven patients were included. Neuropsychiatric syndromes were found 29 (61.7%): seizures (17 / 36.2%), intractable headache (7 / 14.9%), mood disorders (5 / 10.6%), cerebrovascular disease (4 / 8.5%), acute confusional state (3 / 6.4%), aseptic meningitis (3 / 6.4%), psychosis (3 / 6.4%), chorea (3 / 6.4%), Guillain-Barré syndrome (2 / 4.3%) and cranial neuropathy (1 / 2.1%). Morbidity indexes (SLEDAI and SLICC) were higher among patients with neuropsychiatric manifestations (p<0.05). CONCLUSION:Neuropsychiatric syndromes are frequent, and add significant morbidity to juvenile systemic lupus erythematosus.

journal_name

Arq Neuropsiquiatr

authors

Spinosa MJ,Bandeira M,Liberalesso PB,Vieira SC,Janz LL Jr,Sá EG,Löhr A Jr

doi

10.1590/s0004-282x2007000300013

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

433-9

issue

2B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2007000300013

journal_volume

65

pub_type

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