[Growth hormone deficiency after treatment of medulloblastoma with radiotherapy in childhood: case report].

Abstract:

:Craniospinal radiation therapy for treatment of brain tumors may result in growth hormone (GH) insufficiency with resultant linear growth retardation, one of the most common complications. We report the case of a 10-year-old boy presenting headache associated to vertigo, nausea and vomiting. A CT scan showed an homogeneous mass in the left cerebelar hemisphere, that was surgically removed. The histopathological examination revealed medulloblastoma and the patient was submitted to craniospinal radiation. He did not present tumor recurrence nor neurological or cognitive deficits during 4 years, but evolved to short stature due to GH deficiency. Nowadays, he is being receiving GH 0,1 U/kg/day and has presented 4cm stature increment after 6 months. The present case highlights the importance in carefully monitoring of children after cranial radiation for oncologic treatment, because they may develop hormonal deficiencies, that can be successfully replaced.

journal_name

Arq Neuropsiquiatr

authors

Goldberg TB,Rodrigues MA,Takata RT,Nogueira CR,Faleiros AT

doi

10.1590/s0004-282x2003000300030

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

482-5

issue

2B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2003000300030

journal_volume

61

pub_type

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