Abstract:
:We describe in this work the presence of extracellular vesicles (EVs) along different cell types, especially cordocytes, in various clinical conditions of the human brain (atherothrombotic disease, cerebral tumors, hygroma durae matris, intracerebral cysts, Moyamoya disease and parenchymatous hematoma) using transmission electron microscopy (TEM). EVs, illustrated as exosomes and microvesicles, were causally related to cell-to-cell communication, and other vital functions of resident cells around the brain parenchyma, either around the cortical vessels or into the subarachnoid space and the reticular arachnoid. Our direct demonstration by TEM of these information transporters in all locations and situations where the cordocytes play coordinating and regulating roles, producing and delivering a significant number of EVs to their targets, remains to be better documented in future studies. This first study on this topic showed clearly that EVs can be important modulators of cell functions with roles in cell activation, differentiation, phenotypic change, cancer progression, from precursor/stem cells to tumoral phenotypes, because EVs are released en masse during key interactions and certain moments.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Pais V,Pais ESdoi
10.3109/01913123.2014.981327subject
Has Abstractpub_date
2015-05-01 00:00:00pages
177-86issue
3eissn
0191-3123issn
1521-0758journal_volume
39pub_type
杂志文章abstract::It is now apparent that light microscopy and histochemistry failed to identify correctly the nature and composition of pigments in various gastrointestinal tract melanoses. In most instances it was thought that the pigment was melanin or a melanin-like substance. Electron microscopy (EM) and electron-probe energy disp...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.3109/01913129509064226
更新日期:1995-07-01 00:00:00
abstract::A glomangioma (glomus tumor) arising in the pituitary region is described. The histologic and ultrastructural features were characteristic. The tumor was composed of epithelioid cells arranged in an organoid fashion around vascular channels and contained scattered mast cells. Electron microscopy revealed tumor cells t...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128409141853
更新日期:1984-01-01 00:00:00
abstract::A peculiar hyaline sarcoplasmic inclusion in the atrial myocytes of old female Syrian hamsters is described. This type of inclusion resembles that described in rare human cardiomyopathy. They have also been described in other rodents and have been speculated eventually to contain atrial natriuretic factor (ANF). The p...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129409016293
更新日期:1994-01-01 00:00:00
abstract::Microsporidia are ubiquitous obligate eukaryotic intracellular parasites that are now felt to be more akin to degenerate fungi than to protozoa. Microsporidia can be highly pathogenic, causing a broad range of symptoms in humans, especially individuals who are immunocompromised. The vast majority of human cases of mic...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120590951257
更新日期:2005-05-01 00:00:00
abstract::In vitro studies have provided much information regarding the process of glomerular AL-amyloidogenesis. Research efforts have been successful in deciphering how glomerulopathic light chains interact with mesangial cells. The sequential steps involved in the genesis of amyloid fibrils include interactions with surface ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2013.861568
更新日期:2014-04-01 00:00:00
abstract::By means of optical and electron microscopy and by atomic absorption spectrophotometry in a graphite chamber, this study evaluated the effect of temperature (22-35 degrees C) on lesions in the kidney, liver, and brain, and on concentrations of lead caused by the administration of 2 and 5 mg/kg/IP of lead acetate to Sw...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129609016324
更新日期:1996-05-01 00:00:00
abstract::Prolonged storage of Karnovsky's fixative, at both 4 and -20 degrees C, is possible in the diagnostic electron microscopy setting. Ultrastructural detail was not compromised in specimens processed in fixative that had been stored for 6 months. Evidence of smooth muscle and neuroendocrine differentiation was present in...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129709021318
更新日期:1997-03-01 00:00:00
abstract::Six intradermal melanocytic nevi, two with and four without intercellular slitlike spaces, were examined by light microscopy and electron microscopy of deparaffinized tissue. The spaces were partially lined by elongated nevus cells and contained a few collagen fibrils. Other features in both groups included an abundan...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128009141438
更新日期:1980-07-01 00:00:00
abstract::Electron-microscopic analysis of the ultrastructure of the Krebs-2 carcinoma ascites cells in the first 90 min immediately after their exposure to fragmented double-stranded DNA has been performed. Morphological attributes of the treated cancer cells indicate the induction in these cells of destructive processes of pr...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2019.1575499
更新日期:2019-01-01 00:00:00
abstract::The aim of this study is to investigate the effects of betulinic acid (BA) on triple-negative breast cancer MDA-MB-231 cells and observe the ultrastructural changes. The concentration of BA required to induce apoptosis in MDA-MB-231 cells has been previously reported. In this study, a cell counting kit-8 proliferation...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2017.1383548
更新日期:2018-01-01 00:00:00
abstract::The ultrastructural appearance of an endometrial stromal nodule with prominent smooth and skeletal muscle differentiation is described. This is the first reported case of endometrial stromal nodule with a heterologous skeletal muscle component and emphasizes the value of electron microscopy and its correlation with im...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129309027783
更新日期:1993-05-01 00:00:00
abstract::Liver biopsies from 16 children with clinical and pathologic evidence of chronic hepatitis have been examined by electron microscopy for cytoplasmic and nuclear changes. Parallel studies by radioimmunoassay on sera from the same patients support the diagnosis of all these cases as non-A, non-B hepatitis (NANB). Ultrat...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128509142152
更新日期:1985-01-01 00:00:00
abstract::The morphology, karyotype, in vitro growth properties, and expression of tyrosine kinase receptors and proto-oncogenes are reported for a newly established large cell undifferentiated lung carcinoma cell line (RVH-6849). The results were analyzed concomitantly with those for two well-established cell lines from an ade...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129209057829
更新日期:1992-07-01 00:00:00
abstract::Mercuric chloride (HgCl(2)) produces an acute renal failure in experimental animal models. Since the mechanism of tubular injury has not completely been clarified, this morpho-quantitative study was undertaken to better understand the effects of 2 sublethal doses (T1=1 mg/kg and T3.5=3.5 mg/kg) of HgCl(2) in rat proxi...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120309921
更新日期:2003-07-01 00:00:00
abstract::Myeloid histocytes of dendritic cells (DCs), Langerhans cells (LCs), and macrophages in varied tissues, as leukemic blasts in acute monoblastic and monocytic leukemia (AML-M5a and M5b), are derived from monocyte progenitors in bone marrow. Based on DC induction from hematopoietic stem cells, myeloid progenitors, and m...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2015.1120838
更新日期:2016-01-01 00:00:00
abstract::Monomorphous pituitary adenomas expressing several hormones by immunocytochemistry are common, whereas adenomas displaying multiple immunoreactivities and consisting of more than one morphologic cell types are rare. Three such unusual pituitary adenomas, surgically removed from two patients with acromegaly and one pat...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131299281635
更新日期:1999-05-01 00:00:00
abstract::Four cases of epithelioid hemangioendothelioma of bone--a borderline malignant tumor of vascular origin--were studied ultrastructurally and immunohistochemically. The epithelioid tumor cells were positive for vimentin, polyclonal and monoclonal cytokeratins, and the endothelial markers factor VIII-related antigen (FVI...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::This article reviews literature on the transition from rudimentary prokaryotic life to eukaryotes. An overview of the differences between these organisms and theories of eukaryogenesis are reviewed. Various methods of investigating the transformation from prokaryotes to eukaryotes are elaborated, including the fossil,...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.1080/01913120050118521
更新日期:2000-03-01 00:00:00
abstract::The morphological changes found in kidneys of patients undergoing chronic Cyclosporine A (CSA) treatment could, despite of numerous attempts, not yet be reproduced in reliable experimental models. The purpose of the present investigation was to systematically scan the in vivo fixed kidneys in CSA treated Wistar rats a...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128709048438
更新日期:1987-01-01 00:00:00
abstract::We report here ultrastructural and immunohistochemical studies of neuroblastic differentiation in the retrospective (n = 17) and prospective (n = 26) series of primitive neuroectodermal tumors (PNETs). By electron microscopy, neuritelike structures containing parallel-oriented microtubules, adhesive plaque junctions, ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129509064217
更新日期:1995-05-01 00:00:00
abstract::Thickening of capillary walls is a feature of many glomerular diseases. Widening of the wall may be produced by deposits and other changes affecting either subepithelial and subendothelial regions or the glomerular basement membrane itself. Careful light microscopic examination using special stains can distinguish som...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128309140784
更新日期:1983-03-01 00:00:00
abstract::A cystadenoma arose in the urachus of a 32-year-old man. The mass was a multilocular cystic tumor filled with light yellow mucoid material. It was located in the anterior abdominal wall between the umbilicus and the dome of the urinary bladder. Overall, the mass was 14 cm x 8 cm x 5 cm, with the largest internal cyst ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129409023225
更新日期:1994-09-01 00:00:00
abstract::Morphologic evidence of intercellular junctions was found between polymorphonuclear leukocytes (PMNs) and between PMNs and tumor cells. All these junctions displayed electron-dense plaques along the plasma membranes with linear spaces in between. These plaques were finely granular and devoid of filaments. Fine granule...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128309141835
更新日期:1983-09-01 00:00:00
abstract::A case of a malignant meningioma arising in the left parapharyngeal space in a 29-year-old woman is reported. Electron microscopic examination of the tumor was critical in establishing the diagnosis. Meningiomas of the parapharyngeal space are extremely rare. This constitutes the first malignant case documented in thi...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129609023238
更新日期:1996-01-01 00:00:00
abstract::A 28-year-old man presented with left cervical lymph node metastases and a 7-cm mass in the left lobe of the liver. Biopsy material from both sites revealed a fibrolamellar hepatocarcinoma (FLHC) with immunocytochemical and ultrastructural evidence of neurosecretory differentiation. The patient refused treatment. He d...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129409016302
更新日期:1994-01-01 00:00:00
abstract::Two problematic spindle cell sarcomas involving upper jawbones in two adult male patients have been studied by histology, immunohistochemistry, and transmission electron microscopy, and respectively graded as low-grade malignancy and high-grade malignancy. While any single methodological study did not allow confident ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131201317101261
更新日期:2001-09-01 00:00:00
abstract::In a vascular anomaly showing moderate edema, the extracellular space appeared apparently normal, exhibiting a membrane to membrane space of about 20 nm in width. In congenital hydrocephalus, this space appeared notably enlarged and occupied by an electron transparent, nonproteinaceous interstitial edema fluid, due to...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120902787076
更新日期:2009-01-01 00:00:00
abstract::A spectrum of 24 benign and malignant nerve sheath tumors and 10 non-neural spindle-cell tumors were studied by light microscopy for the presence of glial fibrillary acidic protein (GFAP) immunoreactivity by the peroxidase-antiperoxidase (PAP) technique. In 8 cases, these results were compared to their electron micros...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128409141487
更新日期:1984-01-01 00:00:00
abstract::Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive lymphoma derived from plasmacytoid dendritic cells or precursor dendritic cells. Despite some 240 reported cases, its morphology and especially ultrastructure has not been satisfactorily studied. A case is reported of a 13 year old boy, who, des...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2013.813998
更新日期:2014-02-01 00:00:00
abstract::Aggregates of parallel microtubules have been found within cisternae of the rough endoplasmic reticulum in cells of six human metastatic melanomas. The tubules have a uniform diameter and regular spacing and in longitudinal sections can be seen to possess a fine periodicity. They are compared with tubuloreticular incl...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128009141389
更新日期:1980-01-01 00:00:00