Abstract:
BACKGROUND:An episode of breakthrough bacteremia, which was defined as positive blood cultures despite appropriate antibiotic therapy, imposes a treatment challenge in the neonatal intensive care unit (NICU). METHODS:All episodes of breakthrough bacteremia from a tertiary level NICU in Taiwan between 2004 and 2011 were analyzed and compared with nonbreakthrough bacteremia. RESULTS:Breakthrough bacteremia was identified in 7.6% (72/942) of neonatal bacteremia, and 43 (59.7%) occurred as recurrent episodes. Gram-negative organisms (41.7%) and fungi (15.3%) accounted for more than half of all microorganisms in breakthrough bacteremia. Compared with nonbreakthrough bacteremia, breakthrough bacteremia was significantly associated with more severe disease, was more likely to require aggressive therapies, and had a higher rate of infectious complications. Previous use of broad-spectrum antibiotics (odds ratio [OR], 7.54; P < .001) and particular microbial etiologies (Pseudomonas aeruginosa: OR, 4.40; P = .025; fungi: OR, 2.70; P = .013) were independent risk factors for developing breakthrough bacteremia. The crude sepsis-attributable mortality rate was greater in breakthrough bacteremia episodes (16.7% vs 6.4%; P = .004), and this condition was independently associated with an increased risk of death (OR, 2.14; 95% confidence interval, 1.04-4.40; P = .040). CONCLUSION:Breakthrough bacteremia is not uncommon (7.6% of all bacteremia) in NICUs and represents a more severe form of neonatal bacteremia that is independently associated with an increased risk of death.
journal_name
Am J Infect Controljournal_title
American journal of infection controlauthors
Tsai MH,Chu SM,Hsu JF,Lien R,Huang HR,Chiang MC,Fu RH,Lee CW,Huang YCdoi
10.1016/j.ajic.2014.09.022subject
Has Abstractpub_date
2015-01-01 00:00:00pages
20-5issue
1eissn
0196-6553issn
1527-3296pii
S0196-6553(14)01205-Xjournal_volume
43pub_type
杂志文章abstract::Using an innovative, covert, in-room observer method to evaluate infection control practices for patients with Clostridioides difficile infection, we found no difference between physician and nursing hand hygiene compliance and contact precaution usage. There was also no diurnal variation in hand hygiene practices, bu...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2019.03.031
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Mobile phones may be contaminated with nosocomial pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to investigate the MRSA contamination rate on doctors' hospital-use-only mobile phones and the efficacy of 222-nm ultraviolet light (UV) disinfection. METHODS:We ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2020.11.011
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:The potential risks associated with "toilet plume" aerosols produced by flush toilets is a subject of continuing study. This review examines the evidence regarding toilet plume bioaerosol generation and infectious disease transmission. METHODS:The peer-reviewed scientific literature was searched to identify...
journal_title:American journal of infection control
pub_type: 杂志文章,评审
doi:10.1016/j.ajic.2012.04.330
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Enterobacter cloacae has become a common cause of nosocomial infections. This study was designed to investigate the pattern of spread of E cloacae during an outbreak in a neonatal intensive care unit. METHODS:Enterobacterial repetitive intergenic consensus polymerase chain reaction was used to examine 111 E...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Information on the rates and factors associated with influenza vaccinations, although limited, is important because it can inform the development of effective vaccination campaigns in a university medical center setting. METHODS:A study was conducted in 2011 to identify individual and organizational level b...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2012.11.020
更新日期:2013-09-01 00:00:00
abstract::A monthly follow-up evaluation of vancomycin-resistant Enterococcus-colonized patients conducted during an outbreak in France revealed that carriage can persist for an extended period. Recurrence was observed despite as many as 3 negative cultures. As a result, we propose another definition for VRE clearance. ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2010.07.003
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:It is generally recognized that the health care system does not have adequate isolation capacity to meet the surge in demand during a major outbreak of airborne infectious disease. Alternatives to engineered isolation rooms undoubtedly will be required as surge isolation requirements exceed the available res...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2008.05.011
更新日期:2009-03-01 00:00:00
abstract::We report macroscopic biofilms on silver hydrogel-coated urinary catheters in 2 patients from 2 different intensive care units. The catheters were removed on observation of a white, jelly layer on the catheters, respectively, 9 and 21 days after insertion. Yeast cells and pseudohyphal structures were observed with mic...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2016.03.042
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Nosocomial bacteremia caused by the contamination of intravenous (IV) infusates is considered rare. Unfortunately, this problem has been underestimated because its identification requires culturing infusates, a procedure not performed routinely. METHODS:This study was conducted in a referral hospital where ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2009.08.015
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The use of chlorhexidine as a strategy to reduce nosocomial infections in patients has been proven useful. Bacterial contamination of health care worker's uniforms during routine patient care has been demonstrated to have potential for horizontal transmission of pathogens. METHODS:We performed a prospective...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2020.01.004
更新日期:2020-10-01 00:00:00
abstract::Disease transmission from percutaneous injury occurs in 2% to 40% of health care workers (HCWs) after exposure to the hepatitis B virus (HBV), in 3% to 10% after exposure to the hepatitis C (HCV) virus, and in 0.2% to 0.5% after exposure to the HIV virus. According to a recently published case-control study from the C...
journal_title:American journal of infection control
pub_type: 杂志文章,评审
doi:10.1016/s0196-6553(97)90094-8
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Hospital rooms play an important role in the transmission of several health care-associated pathogens. During the last few years, a number of innovative cleaning-disinfecting products have been brought to market. In this study, commercially available products combining cleaning and disinfection were compared...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2017.04.290
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Health care workers (HCWs) use their mobile phones during working hours or medical care. There is evidence that the instruments are colonized with pathogenic microorganisms. Here, we describe levels of Enterobacteriaceae contamination (EC) in cell phones and the risk factors associated with EC in Peruvian in...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2016.02.020
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Airborne infection isolation rooms (AIIRs) help prevent the spread of infectious agents in hospitals. The performance of 678 AIIRs was evaluated and compared with construction design guidelines. METHODS:The pressure differentials (DeltaP) between the isolation rooms and adjacent areas were measured, and ven...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2006.10.012
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Since the introduction in the 1970s of surgical hand scrub formulations that contain 4% chlorhexidine gluconate (CHG), new surgical scrub formulations that have improved efficacy, persistence, or significantly improved use characteristics have not been forthcoming. In addition, the manufacturer's labeling fo...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/s0196-6553(98)70024-0
更新日期:1998-10-01 00:00:00
abstract::A comparison of 2 different influenza seasons (2013-2014 and 2014-2015) where early vaccination among health care providers (HCPs) in the latter was the difference. Differences in leave of absence because of influenza-like illness (ILI) (52 vs 15 [total number of leave of absence issued], P < .001) and total days of l...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2015.10.005
更新日期:2016-02-01 00:00:00
abstract::In a series of experiments, the barrier integrity of single and double vinyl and latex examination gloves were tested for dye and water leaks after being placed under stress. A total of 886 examination gloves (385 vinyl: single, 199; double, 186; and 501 latex: single, 290; double, 211) were tested with a standardized...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(94)90085-x
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Handwashing with soap or another antisepsis disinfectant solution is a common practice in Vietnam, but the availability and quality of tap water is unpredictable. We assessed the risk for hand contamination and compared the efficacy of 5 hand hygiene methods in a tertiary Vietnamese hospital. METHODS:Five f...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2013.07.013
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The pandemic coronavirus disease 2019 (COVID-19) has taken a heavy toll on human life and has upended the medical system in many countries. The disease has created a system wide worsening shortage of N95, medical masks, and other personal protective equipment (PPE) that is regularly used by healthcare person...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2020.07.022
更新日期:2020-07-28 00:00:00
abstract::Dental sterilization techniques have become a focus of attention as a result of disclosure of occupational HIV transmission from an infected dentist to a cluster of patients. Although there has never been a confirmed report of a patient acquiring an infectious blood-borne disease from a dental instrument or device, re...
journal_title:American journal of infection control
pub_type: 杂志文章,评审
doi:10.1016/0196-6553(94)90119-8
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Comparability of the 2 commercially available tuberculin skin testing (TST) preparations, Aplisol (Parkdale Pharmaceuticals, Inc, Rochester, MI) and Tubersol (Aventis Pasteur, Inc, Swiftwater, PA), remains uncertain, particularly in groups that undergo repeated testing, such as health care workers. METHODS:...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2006.05.288
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Success in any antibiotic treatment depends on many factors, including the associated preparation procedures and the nursing care management. OBJECTIVE:The aim of this research was to analyze errors in nursing procedures in the use of cefepime. METHODS:A survey was performed in the adult patients' wing of ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2005.08.011
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:With the increasing volume of same-day operations and shortened hospital stays, it becomes more likely that a significant percentage of surgical site infections will occur after these patients' discharges. METHODS:To document the true incidence of postdischarge surgical site infection, surveillance was unde...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(95)90004-7
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:The Centers for Disease Control and Prevention recently introduced the concept of mucosal barrier injury (MBI) in an attempt to recognize the possibility of a gastrointestinal source for certain bloodstream infections. This could underestimate the central venous catheter (CVC) as the source of central line-a...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2016.03.011
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Chlorhexidine gluconate (CHG) and povidone iodine (PI) are rarely used concurrently despite a lack of evidence regarding functional incompatibility of these agents. METHODS:CHG and PI, alone and combined, were evaluated against Staphylococcus aureus (methicillin-susceptible S aureus [MSSA] and methicillin-r...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2010.06.022
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Methicillin-resistant coagulase-negative staphylococci (MRCNS) are increasing nosocomial pathogens in acute care hospital patients. However, there is little information on the epidemiology of MRCNS in skilled nursing facilities (SNFs). We report a pilot survey of the prevalence of MRCNS colonization in SNF p...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1067/mic.2000.103243
更新日期:2000-06-01 00:00:00
abstract::Several authors have proposed the use of statistical process control charting methods for the surveillance of endemic rates of nosocomial infections. The principal goal of such a charting program is to recognize any increase of the endemic rate to an epidemic rate as soon as possible after the change occurs. However, ...
journal_title:American journal of infection control
pub_type: 杂志文章,评审
doi:10.1067/mic.2000.106277
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:Blood culture contamination with gram-positive organisms is a common occurrence in patients suspected of bloodstream infections, especially in emergency departments. Although numerous research studies have investigated the cost implications of blood culture contamination, a contemporary systematic review of ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2018.12.020
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is a challenge for public health, and community-acquired (CA) infections seem to be increasing among people in different areas. METHODS:A total of 700 healthy student volunteers residing in dormitories of universities in Urmia, Iran, were enrolled in this s...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2017.02.034
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:The hand hygiene technique that the World Health Organization recommends for cleansing hands with soap and water or alcohol-based handrub consists of 7 poses. We used an automated training system to improve clinicians' hand hygiene technique and test whether this affected hospitalwide hand hygiene complian...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2015.04.201
更新日期:2015-08-01 00:00:00