Abstract：
BACKGROUND:Chlorhexidine gluconate (CHG) and povidone iodine (PI) are rarely used concurrently despite a lack of evidence regarding functional incompatibility of these agents. METHODS:CHG and PI, alone and combined, were evaluated against Staphylococcus aureus (methicillin-susceptible S aureus [MSSA] and methicillin-resistant S aureus [MRSA]), Staphylococcus epidermidis (MRSE), Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli using checkerboard microbroth dilution techniques. Minimum bactericidal concentration (MBC) was the concentration (percent wt/vol) that reduced bacterial burden ≥ 5-log(10) colony-forming units/mL at 2 hours when compared with bacterial densities in growth controls. Fractional bactericidal concentration indexes (FBCIs) were calculated to determine CHG and PI compatibility. Additionally, tissue plugs from freshly excised porcine vaginal mucosa were infected with S aureus (MSSA), treated for 2 hours with CHG 3%, PI 5%, or CHG 3% and PI 5% combined and then viable bacteria on the tissue plugs enumerated. RESULTS:In broth, CHG demonstrated dose-dependent bactericidal activity, whereas PI activity was all-or-none. All isolates studied were similarly susceptible to CHG (MBCs: 0.0078% ± 0.0019%, 0.0069% ± 0.0026%, 0.0024% ± 0.0005%, 0.0024% ± 0.0005%, 0.0059% ± 0.0%, and 0.0029% ± 0.0%, respectively). The MBCs of PI were identical (0.625%) for all isolates. Overall, FBCI calculations showed indifference. Treatment of MSSA-infected porcine tissue for 2 hours demonstrated that the CHG-PI combination was superior to either antiseptic alone. CONCLUSION:FBCIs, determined in broth culture, indicate that combining CHG and PI had no negative impact on antisepsis. Moreover, data from an ex vivo porcine mucosal infection model suggest a potential benefit when combining the 2 antiseptic agents.
journal_name
Am J Infect Controljournal_title
American journal of infection controlauthors
Anderson MJ,Horn ME,Lin YC,Parks PJ,Peterson MLdoi
10.1016/j.ajic.2010.06.022subject
Has Abstractpub_date
2010-12-01 00:00:00pages
826-31issue
10eissn
0196-6553issn
1527-3296pii
S0196-6553(10)00808-4journal_volume
38pub_type
杂志文章abstract：:The antibacterial efficacy of 4% chlorhexidine gluconate (CHG) and 1% triclosan as handwash antiseptics is well established. Few published studies have identified hand bacteria found in glove juice samples, and most studies have used nonclinical study subjects. We report a longitudinal comparative study to determine t...
journal_title：American journal of infection control
pub_type： 临床试验,杂志文章
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更新日期：1999-08-01 00:00:00
abstract：BACKGROUND:Healthcare workers perform hand hygiene much more frequently than workers in other fields. As a result, healthcare workers have a higher exposure to topical antiseptic products. METHODS:Five tertiary care facilities were equipped with an electronic hand hygiene compliance monitoring system. Alcohol-based ha...
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journal_title：American journal of infection control
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journal_title：American journal of infection control
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journal_title：American journal of infection control
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abstract：BACKGROUND:Previous data suggest that nursing students in the United States are inadequately protected against hepatitis B. This survey focused on the immunization and education practices, infection control knowledge, and follow-up to infectious disease exposure by U.S. nursing schools. METHODS:To ascertain education ...
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journal_title：American journal of infection control
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ajic.2003.07.008
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Hand hygiene is an effective strategy for the prevention of health care-associated infection (HAI). We investigated the effect of a hand hygiene promotion strategy introducing alcohol-based handrub (AHBR) on the incidence of HAI in a university hospital in Colombia. METHODS:A Prospective cohort study was pe...
journal_title：American journal of infection control
pub_type： 杂志文章
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journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2020.12.008
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journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2009.11.003
更新日期：2010-06-01 00:00:00
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journal_title：American journal of infection control
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2006.12.008
更新日期：2007-10-01 00:00:00
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journal_title：American journal of infection control
pub_type： 临床试验,杂志文章
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更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Following a period (2009-2012) during which zero measles cases were reported, a measles outbreak occurred in 2013 in Bama County, Guangxi, China, that involved more than 100 children younger than age 8 months. We aimed to identify the pitfalls and risk factors while implementing the control measures. METHOD...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2015.11.005
更新日期：2016-04-01 00:00:00
abstract：:There were 256 health care workers in 39 facilities who were interviewed about their perceptions of the quality of care of patients with and without multidrug-resistant organisms based on a standardized questionnaire. There are remarkable differences in the responses between facility types (acute care hospitals, long-...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2015.12.039
更新日期：2016-06-01 00:00:00
abstract：:Many different treatment options are available for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), which are important causes of morbidity and mortality. Although guidelines for the diagnosis and treatment of HAP and VAP have been published by various American and European societies, these...
journal_title：American journal of infection control
pub_type： 杂志文章,实务指引
doi：10.1016/j.ajic.2007.01.015
更新日期：2008-05-01 00:00:00
abstract：:In a simultaneous assessment of 250 environmental surfaces after terminal cleaning using aerobic cultures as a gold standard, both fluorescent marker and an adenosine triphosphate bioluminescence assay system demonstrated better diagnosticity compared with subjective visual inspection. These results support the use of...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2012.09.019
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Clostridium difficile is an important pathogen in Canadian health care facilities, and infection prevention and control (IPC) practices are crucial to reducing C difficile infections (CDIs). We performed a cross-sectional study to identify CDI-related IPC practices in Canadian health care facilities. METHOD...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2011.01.007
更新日期：2011-04-01 00:00:00
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journal_title：American journal of infection control
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Studies conducted in the first decade of the AIDS epidemic indicated that, in general, dentists had suboptimal levels of compliance with standard infection control practices, including work practices designed to reduce exposure to bloodborne pathogens. This study was designed to assess current rates of compl...
journal_title：American journal of infection control
pub_type： 杂志文章
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更新日期：1998-02-01 00:00:00
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journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2016.03.042
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:The role of the infection preventionist (IP) has become increasingly complex, underscoring the need for rapid mechanisms of knowledge acquisition. One mechanism for knowledge acquisition is knowledge-sharing through social networks. In a state such as Kentucky with predominantly rural health care facilities,...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2011.05.018
更新日期：2012-06-01 00:00:00
abstract：:Although substantial improvements in hand hygiene practices have occurred in recent years, many health care facilities continue to encounter challenges in achieving and maintaining high levels of hand hygiene compliance. Issues of current interest include the optimum dose of alcohol-based handrub (ABHR) that should be...
journal_title：American journal of infection control
pub_type： 杂志文章,评审
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更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Infection control partially depends on hygiene and communication skills. Unfortunately, motivation for continuous training is lower than desired. Many health care providers (HCPs) do not recognize the need for training but express this need for others. This is attributable to heuristic errors, such as the ov...
journal_title：American journal of infection control
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
abstract：:Electronic monitoring of hand hygiene compliance using the World Health Organization's My 5 Moments for Hand Hygiene is a new innovation that has not yet been shown to reduce hospital infections. We analyzed existing data from 23 inpatient units over a 33-month period and found a significant correlation between unit-s...
journal_title：American journal of infection control
pub_type： 杂志文章
doi：10.1016/j.ajic.2016.04.215
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:The objectives of this integrative review were to critically examine the overall state of the current evidence on the relationship between hand hygiene interventions and the incidence of health care-associated infections (HCAIs) in acute care and long-term care settings, and offer recommendations for future ...
journal_title：American journal of infection control
pub_type： 杂志文章,评审
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更新日期：2008-06-01 00:00:00
abstract：:The Veterans Affairs methicillin-resistant Staphylococcus aureus (MRSA) Prevention Initiative was implemented in its 133 long-term care facilities in January 2009. Between July 2009 and December 2012, there were ~12.9 million resident-days in these facilities nationwide. During this period, the mean quarterly MRSA adm...
journal_title：American journal of infection control
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) isolated from frequently touched dental school clinic surfaces were compared with MRSA isolated nasal cultures of dental students. METHOD:Sixty-one dental students and 95 environmental surfaces from 7 clinics were sampled using SANICULT (Starplex Scientific...
journal_title：American journal of infection control
pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
abstract：:The appropriate use of antibiotics in nosocomial infections has been a goal of infectious disease practitioners and hospital epidemiologists since the emergence of resistant staphylococci more than 30 years ago. This challenge has assumed new proportions in the 1980s for many reasons. First, resistant gram-positive an...
journal_title：American journal of infection control
pub_type： 杂志文章,评审
doi：10.1016/0196-6553(89)90188-0
更新日期：1989-10-01 00:00:00
