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Comparison of antimicrobial resistance in neonatal and adult intensive care units in a tertiary teaching hospital.

Abstract：

:Intrahospital variations in antimicrobial profiles may be related to many factors. This study compared causative agents of nosocomial bloodstream infections between a neonatal intensive care unit (NICU) that adopted a ward-tailored antibiotic policy and adult intensive care units (ICUs). Data on organisms from blood cultures obtained from the respective wards between 2005 and 2009 were analyzed. Compared with the adult ICUs, the NICU had a higher frequency of Enterobacteriacae and lower frequencies of typical hospital-acquired pathogens (eg, Klebsiella pneumoniae, 17.4% vs 10.0% [P < .001]; Acinetobacter baumannii, 3.9% vs 11.6% [P < .001]). Antibiotic resistance of gram-negative organisms was also significantly lower in the NICU, including resistance to imipenem (5.7% vs 32.1%; P < .001), amikacin (8.8% vs 30.3%), and ceftriaxone (36.1% vs 74.6%; P < .001). This could possibly be due to the ward-tailored antibiotic policy adopted by the NICU but not by the other ICUs.

journal_name

Am J Infect Control

journal_title

American journal of infection control

authors

Ariffin N,Hasan H,Ramli N,Ibrahim NR,Taib F,Rahman AA,Mohamed Z,Wahab S,Isaacs D,Van Rostenberghe H

doi

10.1016/j.ajic.2012.02.032

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

572-5

issue

6

eissn

0196-6553

issn

1527-3296

pii

S0196-6553(12)00712-2

journal_volume

40

pub_type

杂志文章

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