Abstract:
:We analyzed trends in prescribing and overdose deaths related to propoxyphene (e.g., Darvon) before and after a 1978-80 informational campaign carried out by the US Food and Drug Administration and the drug's manufacturer through mailed warnings, face-to-face education of prescribers, press releases, and labeling changes. The goals included a reduction in propoxyphene use with alcohol or other CNS depressants, reduced prescribing of refills, and cessation of prescribing for patients at risk of abuse and misuse (suicide). We conducted time-series analyses of nationwide propoxyphene use data 1974-83 and analyzed data on drug overdose death rates covering a combined population of about 83 million. Segmented regression methods were used to determine if the informational program was associated with changes in trends of prescribing or overdose deaths. Comparison drug series were analyzed to control for other secular trends in prescribing. Nationwide propoxyphene use during the warnings continued a pre-existing decline of about 8 per cent per year, but this decline halted after the warnings. The no-refill recommendation had no impact on refill rates. The risk of overdose death per propoxyphene prescription filled has remained about constant since 1979. Sharper declines in misuse of such drugs will require stronger, more sustained regulatory or educational measures.
journal_name
Am J Public Healthjournal_title
American journal of public healthauthors
Soumerai SB,Avorn J,Gortmaker S,Hawley Sdoi
10.2105/ajph.77.12.1518subject
Has Abstractpub_date
1987-12-01 00:00:00pages
1518-23issue
12eissn
0090-0036issn
1541-0048journal_volume
77pub_type
杂志文章abstract:OBJECTIVES:I examined genetic influences on smoking among adolescents and differences in the heritability of smoking across states in the United States. METHODS:With data from the National Longitudinal Study of Adolescent Health (participants aged 12-21 years), I used a multilevel twin- and sibling-pair (N = 2060 pair...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2008.134932
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:This study determined the effect of provider (nurse or teacher) and training method (workshop or self-preparation) on outcomes of a social influences smoking prevention program. METHODS:One hundred elementary schools were stratified by school risk score (high risk = high smoking rate among senior students) ...
journal_title:American journal of public health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2105/ajph.89.12.1827
更新日期:1999-12-01 00:00:00
abstract::In data from the Texas Educational Agency and the Health Resources and Services Administration, we found fewer autism diagnoses in school districts with higher percentages of Hispanic children. Our results are consistent with previous reports of autism rates 2 to 3 times as high among non-Hispanic Whites as among Hisp...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2008.150565
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:We examined changes in service use in a Housing First (HF) pilot program for adults who were homeless with medical illnesses and high prior acute-care use relative to a similar comparison group. METHODS:We used a 1-year pre-post comparison group design. The 29 participants and 31 comparison group members we...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2012.300867
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:We examined the joint associations of marital status and duration of cohabitation on self-reported intimate partner violence, substance use, and postpartum depression among childbearing women. METHODS:We analyzed data from the 2006-2007 Canadian Maternity Experiences Survey, a cross-sectional nationwide sam...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2012.301116
更新日期:2013-02-01 00:00:00
abstract::To study the effects of a comprehensive, multifaceted intervention program to reduce fireworks-related injuries during the Italian New Year's holiday season, active surveillance was conducted in the 18 public emergency rooms of Naples, Italy, before and after implementation of the program. Preintervention data collect...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.86.1.84
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:We evaluated the effect of North American public bicycle share programs (PBSPs), which typically do not offer helmets with rentals, on the occurrence of bicycle-related head injuries. METHODS:We analyzed trauma center data for bicycle-related injuries from 5 cities with PBSPs and 5 comparison cities. We use...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2014.302012
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:The incidence, type, severity, and costs of crash-related injuries requiring hospitalization or resulting in death were compared for helmeted and unhelmeted motorcyclists. METHODS:This was a retrospective cohort study of injured motorcyclists in Washington State in 1989. Motorcycle crash data were linked to...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.86.1.41
更新日期:1996-01-01 00:00:00
abstract::African Americans and Hispanics are disproportionately affected by the HIV/AIDS epidemic. Within the most heavily affected cities, a few neighborhoods account for a large share of new HIV infections. Addressing racial and economic disparities in HIV infection requires an implementation program and research agenda that...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2013.301864
更新日期:2014-05-01 00:00:00
abstract::We explore how a 1987 New York State court decision-Boreali v. Axelrod-affected public health rule-making nationally and, with considerable impact, locally in New York City (NYC).We discuss the history of the origin of the NYC Board of Health (BOH), and establish that legislatures can be challenging venues in which to...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2018.304755
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:We investigated whether eating behaviors were concordant among diverse sets of social ties. METHODS:We analyzed the socioeconomic and demographic distribution of eating among 3418 members of the Framingham Heart Study observed from 1991 to 2001. We used a data-classification procedure to simplify choices in...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2011.300282
更新日期:2011-11-01 00:00:00
abstract::To evaluate helmet use in California before and after the introduction of an unrestricted helmet use law on January 1, 1992, observations of motorcycles and their riders were made at 60 locations in seven California counties, twice before and four times after the law was introduced. Helmet use increased from about 50%...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.85.1.96
更新日期:1995-01-01 00:00:00
abstract::Growing evidence indicates that women in prison are particularly vulnerable to many negative health outcomes, including cervical cancer. The Papanicolaou (Pap) test is an effective tool to screen for this disease. To determine what is and is not working with the Pap test and follow-up treatment, we performed qualitati...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2005.063677
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVES:We examined associations between immigration and acculturation attributes and oral disease among immigrants. METHODS:We conducted a large cross-sectional study of 1318 immigrants in New York City. We performed comprehensive interviews and oral examinations of the participants and used linear regression mode...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2008.149799
更新日期:2009-10-01 00:00:00
abstract::Dietary intakes of nutrients implicated in cardiovascular disease were studied in 143 Black females, age 9 years. Dietary recall interviews were conducted and data compared with recommendations of several authoritative groups. A majority of subjects reported intakes: exceeding recommendations for total fat, saturated ...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.75.11.1323
更新日期:1985-11-01 00:00:00
abstract::The relationship between corneal arcus (arcus senilis) and mortality from coronary heart disease (CHD) and cardiovascular disease (CVD) is examined in a prospective study of White men (n = 3,930) and women non-hormone users (n = 2,139), ages 30-69, followed for an average of 8.4 years as part of the Lipid Research Cli...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.80.10.1200
更新日期:1990-10-01 00:00:00
abstract::Unanswered questions about racial and socioeconomic health disparities may be addressed using community-based participatory research and systems science. Community-based participatory research is an orientation to research that prioritizes developing capacity, improving trust, and translating knowledge to action. Syst...
journal_title:American journal of public health
pub_type: 信件
doi:10.2105/AJPH.2015.302944
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:In this study, we examine the impact of a school-based curriculum designed to reduce violence among urban sixth-grade students. METHODS:This study used a staggered implementation design in which sixth-graders in six middle schools were taught an 18-session violence-prevention curriculum during either the fa...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.87.6.979
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Studies have indicated that cigarette smokers have more occupational accidents and injuries and use more sick time and health benefits than nonsmokers, thereby producing sizeable costs for employers. However, they usually have not controlled for other possible sources of these costs. We analyzed occupational...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.82.1.29
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Recent studies have shown considerable variation in body fatness among children and adolescents defined as obese by a percentile rank for skinfold thickness. METHODS:We examined the relationship between percent body fat and risk for elevated blood pressure, serum total cholesterol, and serum lipoprotein rat...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.82.3.358
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of abortion among population groups and changes in rates between 2008 and 2014. METHODS:We used secondary data from the Abortion Patient Survey, the American Community Survey, and the National Survey of Family Growth to estimate abortion rates. We used information from the Abortion ...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2017.304042
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:To improve our understanding of climate variability and diarrheal disease at the community level and inform predictions for future climate change scenarios, we examined whether the El Niño climate pattern is associated with increased rates of diarrhea among Peruvian children. METHODS:We analyzed daily surve...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2011.300573
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVES:Message tailoring, based on individual needs and circumstances, is commonly used to enhance face-to-face patient counseling. Only recently has individual tailoring become feasible for printed messages. This study sought to determine whether printed tailored recommendations addressing women's specific screeni...
journal_title:American journal of public health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2105/ajph.84.1.43
更新日期:1994-01-01 00:00:00
abstract::Municipal swimming pools and wading pools were examined for the presence of human enteric viruses using a portable virus concentrator at the site to concentrate viruses from 100-gallon to 500-gallon samples. Ten of 14 samples contained viruses; three of these were positive for virus in the presence of residual free ch...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.71.9.1026
更新日期:1981-09-01 00:00:00
abstract:OBJECTIVES: To investigate the impact of Be the Exception, a newly developed program to delay onset of sexual behaviors, in a White, rural population. METHODS: A cluster randomized controlled trial in northwestern Indiana (14 schools, 1776 students, 2011-2015) compared an intervention (5 group sessions and multimedia ...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/AJPH.2016.303438
更新日期:2016-09-01 00:00:00
abstract::Several epidemiologists have published papers in major medical journals in which they compare incidence rates and prevalence and use these comparisons to support conclusions regarding questions of major public health importance. Although these papers have been criticized in published correspondence, we believe that co...
journal_title:American journal of public health
pub_type: 杂志文章,评审
doi:10.2105/ajph.79.9.1301
更新日期:1989-09-01 00:00:00
abstract::To determine the percentage of unintentional firearm-related injuries associated with hunting and to identify risk factors, we conducted a retrospective, descriptive survey of all hunting firearm injuries identified by two North Carolina surveillance systems. Almost one-third of unintentional shooting deaths are hunti...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.78.12.1585
更新日期:1988-12-01 00:00:00
abstract::Data from the Hispanic Health and Nutrition Examination Survey were used to examine the influence of acculturation on alcohol consumption among Puerto Rican, Cuban-American, and Mexican-American women in the United States. Acculturation was found to be positively related to frequency of consumption and probability of ...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.83.6.890
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVES:From 1985 to 1995, drivers younger than 21 years experienced a 50% drop in fatal crashes involving alcohol. This study addresses whether the decrease is explained by young drivers' drinking less or by their separating drinking from driving. METHODS:Nighttime roadside surveys were conducted in 3 communities ...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.89.5.755
更新日期:1999-05-01 00:00:00
abstract::During 33 screening sessions in Denver gay steambaths, 48 of 419 (11.5 per cent) men were found to have asymptomatic gonorrhea and six (1.4 per cent) had early latent syphilis. Questionnaires were administered to 160 men who reported a mean of 7.9 different male sex contacts per month. Female sex contacts were also re...
journal_title:American journal of public health
pub_type: 杂志文章
doi:10.2105/ajph.67.8.740
更新日期:1977-08-01 00:00:00