Abstract：
:Pigs as a source of grafts for xenotransplantation can help to overcome the rapidly growing shortage of human donors. However, in the case of pig-to-human transplantation, the antibody-xenoantigen complexes lead to the complement activation and immediate hyperacute rejection. Methods eliminating hyperacute rejection (HAR) include α1,3-galactosyltransferase (GGTA1) inactivation, regulation of the complement system and modification of the oligosaccharide structure of surface proteins. The humoral immune response control and reduction of the risk of coagulation disorders are the priority tasks in attempts to overcome acute humoral xenograft rejection that may occur after the elimination of HAR. The primary targets for research are connected with the identification of obstacles and development of strategies to tackle them. Because of the magnitude of factors involved in the immune, genetic engineers face a serious problem of producing multitransgenic animals in the shortest possible time.
journal_name
J Appl Genetjournal_title
Journal of applied geneticsauthors
Zeyland J,Lipiński D,Słomski Rdoi
10.1007/s13353-014-0261-6subject
Has Abstractpub_date
2015-05-01 00:00:00pages
211-8issue
2eissn
1234-1983issn
2190-3883journal_volume
56pub_type
杂志文章,评审abstract：:Some changes in chromosome morphology, detected during cytogenetic analysis, are not associated with clinical defects. Therefore a proper discrimination of harmless variants from true abnormalities, especially during prenatal diagnosis, is crucial to allow precise counseling. In this review we described chromosome var...
journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
doi：10.1007/BF03194674
更新日期：2007-01-01 00:00:00
abstract：:Porcine pregnancy-associated glycoprotein genes (pPAG) are known as a multigene family, in which five members have been cloned and sequences of their cDNAs identified. Porcine PAG1 and pPAG3 genes, belonging to the pPAG1-like subfamily, both encode enzymatically inactive precursors. In contrast, cDNAs of pPAG2, pPAG4 ...
journal_title：Journal of applied genetics
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doi：
更新日期：2001-01-01 00:00:00
abstract：:The genetic basis of the regeneration process in cultured immature embryos of rye (Secale cereale L.) was analyzed. The experiments were designed to reveal differences between the in vitro culture responses of two inbred lines: L318 (a high regeneration ability) and L9 (a low potential for regeneration). The rye ortol...
journal_title：Journal of applied genetics
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doi：10.1007/s13353-010-0015-z
更新日期：2011-02-01 00:00:00
abstract：:Niemann-Pick type C1 (NPC) disease is an autosomal recessive neurodegenerative disorder. One feature of the mouse model of NPC1 is it's infertility. We have made transgenic mice which express the Npc1 protein exclusively in fibrillary astrocytes, using the glial fibrillary acidic protein (GFAP) promoter. This selectiv...
journal_title：Journal of applied genetics
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abstract：:Phenylketonuria (PKU) is a metabolic disease caused by mutations in the phenylalanine hydroxylase (PAH) gene. Although the PAH genotype remains the main determinant of PKU phenotype severity, genotype-phenotype inconsistencies have been reported. In this study, we focused on unanalysed sequences in non-coding PAH gene...
journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：10.1007/s13353-016-0359-0
更新日期：2017-02-01 00:00:00
abstract：:The ErbB signalling network plays a crucial role in the growth and progression of several cancers, including colorectal cancer (CRC), and includes potentially drug-targetable genes. Oncogenic activation of the ErbB pathway by mutations and focal amplifications have emerged recently as an important predictive marker of...
journal_title：Journal of applied genetics
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更新日期：2015-05-01 00:00:00
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journal_title：Journal of applied genetics
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更新日期：2017-08-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
abstract：:Recently, leaf rust and yellow rust caused by the fungi Puccinia triticina Erikss. and P. striiformis Westend f. sp. tritici Eriks and Henn are diseases of increasing threat in triticale (× Triticosecale Wittmack, AABBRR, 2n = 6x = 42) growing areas. The use of genetic resistance is considered the most economical, eff...
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doi：10.1007/s13353-020-00562-8
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journal_title：Journal of applied genetics
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更新日期：2021-02-01 00:00:00
abstract：:Genetic relationships among 20 elite wheat genotypes were studied using microsatellite markers and pedigree analysis. A total of 93 polymorphic bands were obtained with 25 microsatellite primer pairs. Coefficient of parentage (COP) values were calculated using parentage information at the expansion level of 5. The ped...
journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Journal of applied genetics
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doi：10.1007/s13353-020-00564-6
更新日期：2020-09-01 00:00:00
abstract：:Establishing translocated populations is a common process to preserve and maintain genetic diversity of threatened species. In 2001, three translocated populations of noble crayfish (Astacus astacus) were established in the Czech Republic, founded by either adult or juvenile individuals from three particular source po...
journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：10.1007/s13353-015-0296-3
更新日期：2016-02-01 00:00:00
abstract：:Psoriasis is a common skin disease with a genetic background and significant human leukocyte antigen (HLA) associations. HLA-Cw6 is the most frequently described association, particularly with psoriasis of the early onset type. Few studies of its correlation with various psoriasis clinical phenotypes and severity of t...
journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
doi：10.1007/s13353-015-0309-2
更新日期：2016-05-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：10.1007/s13353-017-0397-2
更新日期：2017-08-01 00:00:00
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journal_title：Journal of applied genetics
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doi：10.1007/BF03195710
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journal_title：Journal of applied genetics
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doi：
更新日期：2004-01-01 00:00:00
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journal_title：Journal of applied genetics
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journal_title：Journal of applied genetics
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journal_title：Journal of applied genetics
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journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Journal of applied genetics
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更新日期：2020-09-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章,评审
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journal_title：Journal of applied genetics
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doi：
更新日期：2005-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章
doi：10.1007/s13353-012-0111-3
更新日期：2012-11-01 00:00:00
