The current state of xenotransplantation.

Abstract:

:Pigs as a source of grafts for xenotransplantation can help to overcome the rapidly growing shortage of human donors. However, in the case of pig-to-human transplantation, the antibody-xenoantigen complexes lead to the complement activation and immediate hyperacute rejection. Methods eliminating hyperacute rejection (HAR) include α1,3-galactosyltransferase (GGTA1) inactivation, regulation of the complement system and modification of the oligosaccharide structure of surface proteins. The humoral immune response control and reduction of the risk of coagulation disorders are the priority tasks in attempts to overcome acute humoral xenograft rejection that may occur after the elimination of HAR. The primary targets for research are connected with the identification of obstacles and development of strategies to tackle them. Because of the magnitude of factors involved in the immune, genetic engineers face a serious problem of producing multitransgenic animals in the shortest possible time.

journal_name

J Appl Genet

authors

Zeyland J,Lipiński D,Słomski R

doi

10.1007/s13353-014-0261-6

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

211-8

issue

2

eissn

1234-1983

issn

2190-3883

journal_volume

56

pub_type

杂志文章,评审
  • Cytological investigations of the interspecific hybrids of Nicotiana tabacum L. x N. glauca Grah.

    abstract::Interspecific amphihaploid and amphidiploid hybrids between Nicotiana glauca Grah. (2n = 24) and N. tabacum L. (2n = 48) cultivars BY 103 and K 326 were analysed. F1 amphihaploids (2n = 36) were viable and completely self- and cross-sterile, and mostly univalents were present during meiosis (with pairing range from 0 ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Trojak-Goluch A,Berbeć A

    更新日期:2003-01-01 00:00:00

  • Genetic relationships among wheat genotypes, as revealed by microsatellite markers and pedigree analysis.

    abstract::Genetic relationships among 20 elite wheat genotypes were studied using microsatellite markers and pedigree analysis. A total of 93 polymorphic bands were obtained with 25 microsatellite primer pairs. Coefficient of parentage (COP) values were calculated using parentage information at the expansion level of 5. The ped...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Sud S,Bains NS,Nanda GS

    更新日期:2005-01-01 00:00:00

  • Decreased neural stem cell proliferation and olfaction in mouse models of Niemann-Pick C1 disease and the response to hydroxypropyl-β-cyclodextrin.

    abstract::The Npc1nih/nih-null model and the Npc1nmf164/nmf164 hypomorph models of Niemann-Pick C1 (NPC1) disease show defects in olfaction. We have tested the effects of the life-prolonging treatment hydroxypropyl-beta-cyclodextrin (HPBCD) on olfaction and neural stem cell numbers when delivered either systemically or by nasal...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-019-00517-8

    authors: Dragotto J,Palladino G,Canterini S,Caporali P,Patil R,Fiorenza MT,Erickson RP

    更新日期:2019-11-01 00:00:00

  • Novel linkage mapping approach using DNA pooling in human and animal genetics. II. Detection of quantitative traits loci in dairy cattle.

    abstract::Selective DNA pooling is an advanced methodology for linkage mapping of quantitative trait loci (QTL) in farm animals. The principle is based on densitometric estimates of marker allele frequency in pooled DNA samples of phenotypically extreme individuals from half-sib, backcross and F(2) experimental designs in farm ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章,评审

    doi:

    authors: Pareek CS,Pareek RS,Walawski K

    更新日期:2002-01-01 00:00:00

  • Marker-assisted selection of diploid and tetraploid potatoes carrying Rpi-phu1, a major gene for resistance to Phytophthora infestans.

    abstract::The Rpi-phu1 gene originates from an interspecific hybrid between Solanum stenotomum and S. phureja, and confers a high level of resistance to Phytophthora infestans (late blight) in potato. The Rpi-phu1 was introduced by crossing at the diploid level into the S. tuberosum gene pool and then transferred to the tetrapl...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195721

    authors: Sliwka J,Jakuczun H,Kamiński P,Zimnoch-Guzowska E

    更新日期:2010-01-01 00:00:00

  • Sequence characteristics and divergent evolution of the chloroplast psbA-trnH noncoding region in gymnosperms.

    abstract::The psbA-trnH intergenic region is among the most variable regions in the gymnosperm chloroplast genome. It is proposed as suitable for DNA barcoding studies and is useful in phylogenetics at the species level. This region consists of two parts differing in their evolutionary characteristics: 1) the psbA 3’UTR (...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03208855

    authors: Hao DC,Chen SL,Xiao PG

    更新日期:2010-01-01 00:00:00

  • Length polymorphism of PCR-amplified genomic fragments of the Pregnancy-Associated Glycoprotein (PAG) gene family in the pig and some other domestic and wild mammals.

    abstract::Porcine pregnancy-associated glycoprotein genes (pPAG) are known as a multigene family, in which five members have been cloned and sequences of their cDNAs identified. Porcine PAG1 and pPAG3 genes, belonging to the pPAG1-like subfamily, both encode enzymatically inactive precursors. In contrast, cDNAs of pPAG2, pPAG4 ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Szafrańska B,Panasiewicz G,Wacławik A

    更新日期:2001-01-01 00:00:00

  • Cytogenetic investigation of Arctic char × brook trout F1, F2 and backcross hybrids revealed remnants of the chromosomal rearrangements.

    abstract::Arctic char (Salvelinus alpinus) and brook trout (Salvelinus fontinalis) hybridize and their offspring is viable and fertile. This may be a real treat for the native European stocks of Arctic char which gene pools might be unintendedly contaminated with the genetic elements of brook trout. On the other hand, hybrids o...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-020-00584-2

    authors: Pomianowski K,Ocalewicz K

    更新日期:2021-02-01 00:00:00

  • Polycyclic aromatic hydrocarbons and PAH-related DNA adducts.

    abstract::Investigations on the impact of chemicals on the environment and human health have led to the development of an exposome concept. The exposome refers to the totality of exposures received by a person during life, including exposures to life-style factors, from the prenatal period to death. The exposure to genotoxic ch...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s13353-016-0380-3

    authors: Ewa B,Danuta MŠ

    更新日期:2017-08-01 00:00:00

  • A novel genotype c.1228C>G/c.1448C-1498C (L371V/Rec-NciI) in a 3-year-old child with type 1 Gaucher disease.

    abstract::Gaucher disease (GD) is an autosomal recessive inborn error of metabolism, resulting from a deficiency of the enzyme glucocerebrosidase, causing an accumulation of the glycolipid glucocerebroside within lysosomes of macrophages in the reticuloendothelial system. Three major clinical forms have been assigned and more t...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195642

    authors: Yassin NA,Muwakkit SA,Ibrahim AO,Kayim IM,Habbal MZ,Chamseddine NM,Musallam KM,Shamseddine AI

    更新日期:2008-01-01 00:00:00

  • A novel TPM2 gene splice-site mutation causes severe congenital myopathy with arthrogryposis and dysmorphic features.

    abstract::To date, only two splice-site mutations within the TPM2 gene have been shown to be causative for congenital myopathies. While the majority of TPM2 gene mutations are causative for nemaline myopathy, cap disease or distal arthrogryposis, some mutations in this gene have been found to be associated with non-specific con...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-016-0368-z

    authors: Mroczek M,Kabzińska D,Chrzanowska KH,Pronicki M,Kochański A

    更新日期:2017-05-01 00:00:00

  • A de novo interstitial 6q deletion in a boy with a split hand malformation.

    abstract::We report on a de novo interstitial deletion of (6)(q15q22.2) in a 5-year-old boy with developmental delay, microcephaly, facial dysmorphism, cryptorchidism, congenital heart defect, and split-hand malformation. Previous reports and this patient suggest that 6q21 may contain a gene or genes related either directly or ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195240

    authors: Duran-Gonzalez J,Gutierrez-Angulo M,Garcia-Cruz D,Ayala Mde L,Padilla M,Davalos IP

    更新日期:2007-01-01 00:00:00

  • Identification of novel candidate genes for the inverted teat defect in sows using a genome-wide marker panel.

    abstract::The number of functional teats is an important selection criterion in pig breeding. Inherited defects of the udder, such as the inverted teat, do have a considerable negative impact on the nursing ability of the sow. To investigate the genetic background of this defect and the number of functional teats in Swedish mat...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-016-0382-1

    authors: Chalkias H,Jonas E,Andersson LS,Jacobson M,de Koning DJ,Lundeheim N,Lindgren G

    更新日期:2017-05-01 00:00:00

  • Genetic control of bacterial biofilms.

    abstract::Nearly all bacterial species, including pathogens, have the ability to form biofilms. Biofilms are defined as structured ecosystems in which microbes are attached to surfaces and embedded in a matrix composed of polysaccharides, eDNA, and proteins, and their development is a multistep process. Bacterial biofilms const...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s13353-015-0309-2

    authors: Wolska KI,Grudniak AM,Rudnicka Z,Markowska K

    更新日期:2016-05-01 00:00:00

  • A new assay based on terminal restriction fragment length polymorphism of homocitrate synthase gene fragments for Candida species identification.

    abstract::Candida sp. have been responsible for an increasing number of infections, especially in patients with immunodeficiency. Species-specific differentiation of Candida sp. is difficult in routine diagnosis. This identification can have a highly significant association in therapy and prophylaxis. This work has shown a new ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-017-0394-5

    authors: Szemiako K,Śledzińska A,Krawczyk B

    更新日期:2017-08-01 00:00:00

  • Mapping QTLs for pre-harvest sprouting tolerance on chromosome 2D in a synthetic hexaploid wheat x common wheat cross.

    abstract::Based on segregation distortion of simple sequence repeat (SSR) molecular markers, we detected a significant quantitative trait loci (QTL) for pre-harvest sprouting (PHS) tolerance on the short arm of chromosome 2D (2DS) in the extremely susceptible population of F2 progeny generated from the cross of PHS tolerant syn...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195631

    authors: Ren XB,Lan XJ,Liu DC,Wang JL,Zheng YL

    更新日期:2008-01-01 00:00:00

  • Founder event and its effect on genetic variation in translocated populations of noble crayfish (Astacus astacus).

    abstract::Establishing translocated populations is a common process to preserve and maintain genetic diversity of threatened species. In 2001, three translocated populations of noble crayfish (Astacus astacus) were established in the Czech Republic, founded by either adult or juvenile individuals from three particular source po...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-015-0296-3

    authors: Bláha M,Žurovcová M,Kouba A,Policar T,Kozák P

    更新日期:2016-02-01 00:00:00

  • A simplified AFLP method for fingerprinting of common wheat (Triticum aestivum L.) cultivars.

    abstract::The simplified AFLP method was developed and evaluated for identification and genetic diversity studies of wheat cultivars. Selective primers exploited in AFLP assay based on a single cutting enzyme PstI ((PstI)AFLP) generated total of 111 robust fragments, including 67 (60%) monomorphic and 12 (11%) cultivar-specific...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Tyrka M

    更新日期:2002-01-01 00:00:00

  • The influence of rye cytoplasm on meiotic stability of tetraploid Secalotriticum.

    abstract::Chromosome pairing in tetraploid Secalotriticum was analysed. In the studied plants wheat chromosomes in PMCs during metaphase I showed a higher degree of pairing, in comparison to the rye genome. This is reflected in a very low frequency of univalents and a higher frequency of ring bivalents. The occurrence of wheat ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Apolinarska B

    更新日期:2003-01-01 00:00:00

  • Gene expression analysis identifies new candidate genes associated with the development of black skin spots in Corriedale sheep.

    abstract::The white coat colour of sheep is an important economic trait. For unknown reasons, some animals are born with, and others develop with time, black skin spots that can also produce pigmented fibres. The presence of pigmented fibres in the white wool significantly decreases the fibre quality. The aim of this work was t...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-011-0066-9

    authors: Peñagaricano F,Zorrilla P,Naya H,Robello C,Urioste JI

    更新日期:2012-02-01 00:00:00

  • Genetic diversity among cultivars, landraces and wild relatives of rice as revealed by microsatellite markers.

    abstract::Genetic diversity among 35 rice accessions, which included 19 landraces, 9 cultivars and 7 wild relatives, was investigated by using microsatellite (SSR) markers distributed across the rice genome. The mean number of alleles per locus was 4.86, showing 95.2% polymorphism and an average polymorphism information content...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195230

    authors: Ram SG,Thiruvengadam V,Vinod KK

    更新日期:2007-01-01 00:00:00

  • Population biobanking in selected European countries and proposed model for a Polish national DNA bank.

    abstract::Population biobanks offer new opportunities for public health, are rudimentary for the development of its new branch called Public Health Genomics, and are important for translational research. This article presents organizational models of population biobanks in selected European countries. Review of bibliography and...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-012-0082-4

    authors: Sak J,Pawlikowski J,Goniewicz M,Witt M

    更新日期:2012-05-01 00:00:00

  • Spectrum of NIPBL gene mutations in Polish patients with Cornelia de Lange syndrome.

    abstract::Cornelia de Lange syndrome (CdLS) is a rare multi-system genetic disorder characterised by growth and developmental delay, distinctive facial dysmorphism, limb malformations and multiple organ defects. The disease is caused by mutations in genes responsible for the formation and regulation of cohesin complex. About ha...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-012-0126-9

    authors: Kuzniacka A,Wierzba J,Ratajska M,Lipska BS,Koczkowska M,Malinowska M,Limon J

    更新日期:2013-02-01 00:00:00

  • Expression of Npc1 in glial cells corrects sterility in Npc1(-/-) mice.

    abstract::Niemann-Pick type C1 (NPC) disease is an autosomal recessive neurodegenerative disorder. One feature of the mouse model of NPC1 is it's infertility. We have made transgenic mice which express the Npc1 protein exclusively in fibrillary astrocytes, using the glial fibrillary acidic protein (GFAP) promoter. This selectiv...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195698

    authors: Donohue C,Marion S,Erickson RP

    更新日期:2009-01-01 00:00:00

  • The KVLQT1 gene is not a common target for mutations in patients with various heart pathologies.

    abstract::The long QT syndrome (LQTS) is a disorder of ventricular repolarization that exposes affected individuals to cardiac arrhythmias and sudden death. The first gene for LQTS has been mapped to chromosome 11 p.15.5 by genome-wide linkage analysis. This gene, originally named KVLQT1 (and later KCNQ1), is a novel potassium ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Moric E,Herbert E,Mazurek U,Samelska J,Cholewa K,Trusz-Gluza M,Wilczok T

    更新日期:2002-01-01 00:00:00

  • CCAAT/enhancer binding protein-beta negatively regulates the expression of glycerol-3-phosphate dehydrogenase 1 in pig PK-15 cells.

    abstract::Soluble glycerol-3-phosphate dehydrogenase 1 (GPD1, EC 1.1.1.8) plays important roles in the synthesis of triacylglycerol and in the glycerol-3-phosphate shutter. Though GPD1 is expressed in most adult tissues, little is known about the regulation of its expression. In this study, we analyzed the characters, organizat...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-011-0050-4

    authors: Gao Y,Pan Y

    更新日期:2011-11-01 00:00:00

  • Effect of flavonoid pigments on the accumulation of fumonisin B1 in the maize kernel.

    abstract::Mycotoxins are secondary metabolites with potential dangers for animal and human health. In particular, maize (Zea mays L.) infection caused by Fusarium and the consequent fumonisin contamination is widespread in several countries such as Italy. We developed six maize populations differing in their constitution of reg...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-010-0014-0

    authors: Pilu R,Cassani E,Sirizzotti A,Petroni K,Tonelli C

    更新日期:2011-05-01 00:00:00

  • Gene expression profiling in skeletal muscle of Holstein-Friesian bulls with single-nucleotide polymorphism in the myostatin gene 5'-flanking region.

    abstract::Myostatin (GDF-8) is a key protein responsible for skeletal muscle growth and development, thus mutations in the mstn gene can have major economic and breeding consequences. The aim of the present study was to investigate myostatin gene expression and transcriptional profile in skeletal muscle of Holstein-Friesian (Bl...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195620

    authors: Sadkowski T,Jank M,Zwierzchowski L,Siadkowska E,Oprzadek J,Motyl T

    更新日期:2008-01-01 00:00:00

  • The MMP2 gene may be associated with longissimus dorsi muscle area in the pig (Sus scrofa).

    abstract::The matrix metalloproteinase-2 gene (MMP2) was found to be associated with hip structure in pigs. Recently three quantitative trait loci (QTLs) for loin muscle area were found on chromosome 6, to which MMP2 was mapped. In the present study, association analyses were conducted in two pig populations for a single-nucleo...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195679

    authors: Onteru SK,Fan B,Rothschild MF

    更新日期:2009-01-01 00:00:00

  • Genome-wide identification, genomic organization and expression profiles of SlARR-B gene family in tomato.

    abstract::The type-B authentic response regulators (ARR-Bs) function as positive regulators of cytokinin signal transduction and play important roles in abiotic stress resistance and plant development. However, little of ARR-B family is known in tomato. In this study, we performed a comprehensive analysis of ARR-B family factor...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-020-00565-5

    authors: Wang J,Xia J,Song Q,Liao X,Gao Y,Zheng F,Yang C

    更新日期:2020-09-01 00:00:00