GC-MS-based plasma metabolomic investigations of morphine dependent rats at different states of euphoria, tolerance and naloxone-precipitated withdrawal.

abstract：:The central nervous system is one of the most vulnerable organs affected by mercury toxicity. Both acute and chronic exposure to mercury is also known to cause a variety of neurological or psychiatric disorders. Here, the neuroprotective effect of berberine (BN; 100 mg/kg bwt) on mercuric chloride (HgCl2; 0.4 mg/kg bw...

journal_title：Metabolic brain disease

authors： Abdel Moneim AE

更新日期：2015-08-01 00:00:00

abstract：:Over the past 35 years, the outlook for a patient presenting with acute liver failure (ALF) has changed beyond all recognition. A patient presenting in 1984 had an 80 % likelihood of succumbing to intracranial hypertension. Today due to dramatic improvements in intensive care in dedicated liver transplant units, this ...

journal_title：Metabolic brain disease

authors： Ryan JM,Tranah T,Mitry RR,Wendon JA,Shawcross DL

更新日期：2013-03-01 00:00:00

abstract：:In the original publication of the article, author name Masoumeh Asadbegi was incorrectly written as Masoumeh Asadbeigi. The authors regret the oversight. ...

journal_title：Metabolic brain disease

authors： Sajadi A,Amiri I,Gharebaghi A,Komaki A,Asadbegi M,Shahidi S,Mehdizadeh M,Asl SS

更新日期：2017-12-01 00:00:00

abstract：:Stress-induced activation of the expression of the endoplasmic reticulum (ER)-resident chaperon and member of the protein disulfide isomerase family erp72 was studied after transient cerebral ischemia in vivo using the four-vessel occlusion method and experimental depletion of ER calcium stores in primary neuronal cel...

journal_title：Metabolic brain disease

authors： Paschen W,Gissel C,Linden T,Doutheil J

更新日期：1998-03-01 00:00:00

abstract：UNLABELLED:Some subjects with multiple sclerosis (MS) present with low blood iron parameters. Anecdotal reports and a single patient study suggest that iron supplementation may be beneficial in these subjects. Myelin is regenerated continually, but prerequisites for this process are iron and a functional folate-vitamin...

journal_title：Metabolic brain disease

authors： van Rensburg SJ,Kotze MJ,Hon D,Haug P,Kuyler J,Hendricks M,Botha J,Potocnik FC,Matsha T,Erasmus RT

更新日期：2006-09-01 00:00:00

abstract：:At the present time alcoholism is recognized as a metabolic disease exhibiting the clinical features of craving for alcohol, loss of control over drinking, tolerance and physical dependence on alcohol, while both epidemiological and experimental studies have demonstrated that genetic factors may be important in determ...

journal_title：Metabolic brain disease

authors： Gianoulakis C,de Waele JP

更新日期：1994-06-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAP kinase) pathway participates in a number of reactions of the cell when responding to various external stimuli. These stimuli include growth factor binding to its receptor as well as stressful situations such as hypoxia and oxidative stress. It has been postulated that one of t...

journal_title：Metabolic brain disease

authors： Daniels WM,Hendricks J,Salie R,Taljaard JJ

更新日期：2001-12-01 00:00:00

abstract：:The original article contains mistake. The authors want to add Wenhui Pei as first co-author and Fang Fang as co-corresponding author. ...

journal_title：Metabolic brain disease

authors： Sun Y,Pei W,Zhang N,Qu Y,Cao Y,Li J,Yang Y,Yang T,Fang F,Sun Y

更新日期：2020-12-01 00:00:00

abstract：:Depression is a complex progressive disorder accompanied by activation of inflammatory and Th-1 driven pathways, oxidative and nitrosative stress (O&NS), lowered antioxidant levels, mitochondrial dysfunctions, neuroprogression and increased bacterial translocation. In depression, activation of immuno-inflammatory path...

journal_title：Metabolic brain disease

authors： Maes M

更新日期：2012-12-01 00:00:00

abstract：:D-Galactose (D-gal) chronic administration via intraperitoneal and subcutaneous routes has been used as a model of aging and Alzheimer disease in rodents. Intraperitoneal and subcutaneous administration of D-gal causes memory impairments, a reduction in the neurogenesis of adult mice, an increase in the levels of the ...

journal_title：Metabolic brain disease

authors： Budni J,Garcez ML,Mina F,Bellettini-Santos T,da Silva S,Luz APD,Schiavo GL,Batista-Silva H,Scaini G,Streck EL,Quevedo J

更新日期：2017-06-01 00:00:00

abstract：:To investigate the pattern of brain volume changes in patients with end-stage renal disease (ESRD) using voxel-based morphometry (VBM) and correlation with clinical and neuropsychological (NP) tests. Fifty seven ESRD patients with no anatomical abnormalities in conventional magnetic resonance imaging [24 patients with...

journal_title：Metabolic brain disease

authors： Zhang LJ,Wen J,Ni L,Zhong J,Liang X,Zheng G,Lu GM

更新日期：2013-12-01 00:00:00

abstract：:Hereditary tyrosinemia type I (HT1) is caused by mutations in the fumarylacetoacetate hydrolase (FAH) gene, the template for the final enzyme in the tyrosine catabolism pathway. If left untreated this deficiency of functional FAH leads to a buildup of toxic metabolites that can cause liver disease, kidney dysfunction ...

journal_title：Metabolic brain disease

authors： Moore ME,Koenig AE,Hillgartner MA,Otap CC,Barnby E,MacGregor GG

更新日期：2017-12-01 00:00:00

abstract：:As studies of brain metabolism grow in complexity, investigators turn increasingly to nuclear magnetic resonance spectroscopy combined with 13C isotopic labeling. The unique ability to detect labeling non-destructively in specific carbon positions of individual compounds has opened the way to investigate brain metabol...

journal_title：Metabolic brain disease

authors： Mason GF,Behar KL,Lai JC

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:To analyze brain metabolite changes in HIV-1-seropositive subjects in order to define whether the neuronal impairment is a localized or more diffuse process. MATERIALS AND METHODS:15 patients and 18 volunteers underwent multivoxel proton magnetic resonance (MR) spectroscopy at 1.5T. Nine patients were classifi...

journal_title：Metabolic brain disease

authors： Marcus CD,Taylor-Robinson SD,Sargentoni J,Ainsworth JG,Frize G,Easterbrook PJ,Shaunak S,Bryant DJ

更新日期：1998-06-01 00:00:00

abstract：:To investigate the hypothesis that neurotoxic metals can exert their toxicity through the direct inhibition of monoamine oxidases (MAOs), the effects of several neurotoxic metal ions on type A (MAO-A) and type B (MAO-B) monoamine oxidase activities in rat forebrain nonsynaptic mitochondria and rat liver mitochondria w...

journal_title：Metabolic brain disease

authors： Leung TK,Lim L,Lai JC

更新日期：1992-09-01 00:00:00

abstract：:Mitochondrial dysfunction is observed in brains of Alzheimer's Disease patients as well as many rodent model systems including those modeling mutations in preseinilin 1 (PSEN1). The aim of our study was to characterize mitochondrial function and number in fibroblasts from AD patients with PSEN1 mutations. We used bioc...

journal_title：Metabolic brain disease

authors： Gray NE,Quinn JF

更新日期：2015-10-01 00:00:00

abstract：:Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states. Nevertheless the link between obesity and emotional disorders still remains to be elucidated. This issue is of particular interest during adolesc...

journal_title：Metabolic brain disease

authors： Wu H,Liu Q,Kalavagunta PK,Huang Q,Lv W,An X,Chen H,Wang T,Heriniaina RM,Qiao T,Shang J

更新日期：2018-02-01 00:00:00

abstract：:In the current era, plants are frequently tested for its antidepressant potential. Therefore young coconut water, a commonly used plant based beverage, was selected to explore its antidepressant potential. Rodents were selected for this study and forced swim test was conducted to explore antidepressant activity. Analy...

journal_title：Metabolic brain disease

authors： Rao SS,Najam R

更新日期：2016-10-01 00:00:00

abstract：:There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is demonstrated that in hepatocellular dysfunction, ammonia detoxification to glutamine (GLN) in skeletal muscle, brain, and likely the lungs, is activated. In addition t...

journal_title：Metabolic brain disease

authors： Holecek M

更新日期：2014-03-01 00:00:00

abstract：:Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in...

journal_title：Metabolic brain disease

authors： Fiacco F,Barbato L,Pecoraro MG,Maggio P

更新日期：2017-02-01 00:00:00

abstract：:Several epidemiological studies have shown that Diabetes Mellitus (DM) or Insulin Resistance (IR) increases the risk of dementia. Besides, some authors suggested that poor glucose control to be associated with worse cognitive function. We aimed to assess cognitive functions and IR-degree over time in diabetic. We also...

journal_title：Metabolic brain disease

authors： Fava A,Colica C,Plastino M,Messina D,Cristiano D,Opipari C,Vaccaro A,Gorgone G,Bosco F,Fratto A,De Bartolo M,Bosco D

更新日期：2017-06-01 00:00:00

abstract：:Bilateral, symmetrical hyperintensity of the globus pallidus is observed in T1-weighted cerebral magnetic resonance images in from 52 to 100% of patients with chronic liver disease. No significant relationship exists between the presence of these cerebral changes in image signal intensity and the patients' neuropsychi...

journal_title：Metabolic brain disease

authors： Morgan MY

更新日期：1998-12-01 00:00:00

abstract：:The aim of this study was to explore the neuroprotective effects of active compounds from Schisandra chinensis (Trucz.) Baill. (Magnoliaceae) against the D-galactose (D-gal)-induced neurotoxicity in rat. The Wistar rats were subcutaneously injected with D-gal (150 mg/(kg day)) for six weeks and orally administered wit...

journal_title：Metabolic brain disease

authors： Yan T,Shang L,Wang M,Zhang C,Zhao X,Bi K,Jia Y

更新日期：2016-06-01 00:00:00

abstract：:Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism ...

journal_title：Metabolic brain disease

authors： Yan X,Lukas J,Witt M,Wree A,Hübner R,Frech M,Köhling R,Rolfs A,Luo J

更新日期：2011-12-01 00:00:00

abstract：:Acute and chronic administration of Al-gluconate (12.7% Al) at the concentration of 1 mg/kg produces edema in the rat brain, as reflected by the increase in water and Na+ content. The permeability for Evans blue is also increased, which indicates the opening of the blood-brain barrier. Higher concentrations of the Al-...

journal_title：Metabolic brain disease

authors： Stefanovich V,Joó F

更新日期：1990-03-01 00:00:00

abstract：:Mutations in NADH dehydrogenase (ND) subunits of complex I lead to mitochondrial encephalomyopathies associated with various phenotypes. This report aims to present the patient's clinical symptomatology in the context of a very rare 13042G>A de novo mutation and with an emphasis on changing phenotypic expression and p...

journal_title：Metabolic brain disease

authors： Schinwelski M,Kierdaszuk B,Dulski J,Tońska K,Kodroń A,Sitek EJ,Bartnik E,Kamińska A,Kwieciński H,Sławek J

更新日期：2015-08-01 00:00:00

abstract：:The permeability of the blood-brain barrier to glutamate was measured by quantitative autoradiography in brains of 7-day-old rats (average plasma glutamate 114 microM) and rats injected subcutaneously with glutamate (average plasma glutamate 2,670 microM). Measurements of glutamate permeability were initiated by the i...

journal_title：Metabolic brain disease

authors： Viña JR,DeJoseph MR,Hawkins PA,Hawkins RA

更新日期：1997-09-01 00:00:00

abstract：:Cadmium is a toxic environmental and industrial pollutant. Cadmium toxicity has been reported to produce biochemical and behavioral dysfunction that may cause adverse effects on several organs including the central nervous system. The present study was designed to investigate the neurotoxic effects of Cadmium Chloride...

journal_title：Metabolic brain disease

authors： Haider S,Anis L,Batool Z,Sajid I,Naqvi F,Khaliq S,Ahmed S

更新日期：2015-02-01 00:00:00

abstract：:Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental retardation, hyperactivity, cerebral palsy, epilepsy and neuroendocrine disturbances. Herein, we exa...

journal_title：Metabolic brain disease

authors： Kartal Ö,Aydınöz S,Kartal AT,Kelestemur T,Caglayan AB,Beker MC,Karademir F,Süleymanoğlu S,Kul M,Yulug B,Kilic E

更新日期：2016-08-01 00:00:00

abstract：:Schizophrenia is one of the most disabling mental disorders that affects up to 1 % of the population worldwide. Although the causes of this disorder remain unknown, it has been extensively characterized by a broad range of emotional, ideational and cognitive impairments. Studies indicate that schizophrenia affects neu...

journal_title：Metabolic brain disease

authors： Zugno AI,Julião RF,Budni J,Volpato AM,Fraga DB,Pacheco FD,Deroza PF,Luca RD,de Oliveira MB,Heylmann AS,Quevedo J

更新日期：2013-09-01 00:00:00