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Early pregnancy vitamin D and patterns of antenatal inflammation in African-American women.

Abstract：

:Vitamin D is essential for the health of both mother and fetus during pregnancy. In the nonpregnant state, vitamin D demonstrates anti-inflammatory effects, but little is known about this relationship during pregnancy. African-American women are at a higher risk of vitamin D deficiency and for altered inflammatory responses during pregnancy. Therefore, we investigated the association of early pregnancy vitamin D nutrition, as assessed by serum 25-hydroxyvitamin D (25-OHD), with second-trimester inflammatory biomarkers (high-sensitivity C-reactive protein, IL-6, IL-10, IL-1β and TNF-α) in 178 pregnant African-American women. Mean serum 25-OHD was 13.4±8.4 ng/ml, and most women (n=147, 82.6%) had inadequate or deficient levels of 25-OHD (<20 ng/ml). Both serum 25-OHD and some inflammatory cytokines (IL-1β and TNF-α) demonstrated significant seasonal variation. In univariate models, log transformed 25-OHD was significantly and inversely associated with log transformed IL-1β (p=0.002) and log transformed IL-6 (p=0.032). After adjusting for covariates, including seasonality, only the inverse association with IL-1β remained statistically significant (p=0.027). Early pregnancy vitamin D nutrition is associated with some inflammatory biomarkers in mid-pregnancy. Additional studies are needed to determine if low vitamin D nutrition is associated with birth outcomes via an inflammatory-mediated pathway.

journal_name

J Reprod Immunol

journal_title

Journal of reproductive immunology

authors

Bobbitt KR,Peters RM,Li J,Rao SD,Woodcroft KJ,Cassidy-Bushrow AE

doi

10.1016/j.jri.2014.09.054

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

52-8

eissn

0165-0378

issn

1872-7603

pii

S0165-0378(14)00140-5

journal_volume

107

pub_type

临床试验,杂志文章

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